Design, synthesis and biological evaluation of paclitaxel-mimics possessing only the oxetane D-ring and side chain structures.

abstract：:A stimulatory effect of apigenin-6-C-β-fucopyranoside (1) on glucose uptake was observed when rat soleus muscle was incubated with 1, 10 and 100 μM of this flavonoid glycoside. The presence of specific insulin signaling inhibitors, such as wortmannin, an inhibitor of phosphoinositide 3-kinase (PI3K), RO318220, an inhi...

journal_title：Fitoterapia

authors： Cazarolli LH,Kappel VD,Pereira DF,Moresco HH,Brighente IM,Pizzolatti MG,Silva FR

更新日期：2012-10-01 00:00:00

abstract：:Four new eburnamine-aspidospermine type bisindole alkaloids, namely, mekongenines C-F (1-4), along with 27 known indole alkaloids were isolated from the twigs and leaves of Bousigonia mekongensis. Their structures with the absolute configurations were elucidated by spectroscopic methods and ECD analyses. All new compo...

journal_title：Fitoterapia

authors： Fu YH,Li SL,Li SF,He HP,Di YT,Zhang Y,Hao XJ

更新日期：2014-10-01 00:00:00

abstract：:Chemical examination of the ethanol extract of rhizomes of Iris tectorum led to the isolation and characterization of three new lignans, (7R,7'R,8S,8'S)-5'-methoxy-neo-olivil (1a), (7S,7'S,8R,8'R) -5'-methoxy-neo-olivil (1b), (7S,7'R,8S,8'S)-neo-olivil (2a), (7R,7'S,8R,8'R)-neo-olivil (2b), (7R,7'R,8S,8'S,7''S,8''S)-t...

journal_title：Fitoterapia

authors： Zhang CL,Wang Y,Liu YF,Liang D,Hao ZY,Luo H,Chen RY,Yu DQ

更新日期：2016-01-01 00:00:00

abstract：:As a part of our ongoing search for plant-derived compounds that inhibit nitric oxide production, the methanol extract of the roots of Vladimiria souliei was found to show significant inhibitory effects on INF-γ-induced nitric oxide production in murine macrophage RAW264.7 cells. Bioactivity-guided isolation of the ex...

journal_title：Fitoterapia

authors： Xu J,Jin D,Shi D,Ma Y,Yang B,Zhao P,Guo Y

更新日期：2011-04-01 00:00:00

abstract：:A new diterpenoid ester, fritillahupehin (1) together with three known fatty acids: palmitic acid (2), lignoceric acid (3) and azelaic acid (4) were isolated from the bulbs of Fritillaria hupehensis Hsiao and K.C. Hsia. The structure of fritillahupehin has been established to be ent-kauran-16beta-yl lignocerate by mea...

journal_title：Fitoterapia

authors： Ruan H,Zhang Y,Wu J,Deng S,Sun H,Fujita T

更新日期：2002-07-01 00:00:00

abstract：:NAtural Deep Eutectic Solvents (NADES) are chemically simple but physiologically important plant constituents that exhibit unique solubilizing properties of other metabolites, including bioactive constituents. The high polarity of NADES introduces a challenge in the ability of conventional solid-support based chromato...

journal_title：Fitoterapia

authors： Liu Y,Garzon J,Friesen JB,Zhang Y,McAlpine JB,Lankin DC,Chen SN,Pauli GF

更新日期：2016-07-01 00:00:00

abstract：:There is growing evidence that motherwort (Leonurus japonicus Houtt.), and Chinese patent medicines derived from motherwort, alleviate postpartum uterine subinvolution, as well as the effects on myocardial and cerebral ischemic injuries. We hypothesized that these beneficial effects of motherwort may be related to ang...

journal_title：Fitoterapia

authors： He YL,Shi JY,Peng C,Hu LJ,Liu J,Zhou QM,Guo L,Xiong L

更新日期：2018-07-01 00:00:00

abstract：:As part of our search for biologically active anti-osteoporotic agents that enhance the differentiation and mineralization of osteoblastic MC3T3-E1 cells, we identified the ginsenoside Rd as the most active compound among ginsenosides. In this study, we showed that Rd stimulates osteoblastic differentiation and minera...

journal_title：Fitoterapia

authors： Kim DY,Park YG,Quan HY,Kim SJ,Jung MS,Chung SH

更新日期：2012-01-01 00:00:00

abstract：:Four new cycloartane triterpenoids, 1α,3β-dihydroxy-16-keto-24(31)-en-cycloartane (1), 31-methoxyl-passifloic acid (2), cyclopassifloside XIV (3), and cyclopassifloside XV (4), together with six known compounds (5-10) were isolated from Passiflora edulis Sims. Their structures were elucidated on the basis of extensive...

journal_title：Fitoterapia

authors： Xu FQ,Wang N,Fan WW,Zi CT,Zhao HS,Hu JM,Zhou J

更新日期：2016-12-01 00:00:00

abstract：:Methanol extract of the stem bark of Hymenodictyon parvifolium was tested for its antifungal and antibacterial activity. The extract was found to have inhibitory effect against all the pathogens tested. ...

journal_title：Fitoterapia

authors： Kariba RM

更新日期：2002-10-01 00:00:00

abstract：:Herbal medicines are the most globally used type of medical drugs. Their high cultural acceptability is due to the experienced safety and efficiency over centuries of use. Many of them are still phytochemically less-investigated, and are used without standardization or quality control. Choosing SIROP KILMA, an authori...

journal_title：Fitoterapia

authors： Tshitenge DT,Ioset KN,Lami JN,Ndelo-di-Phanzu J,Mufusama JP,Bringmann G

更新日期：2016-04-01 00:00:00

abstract：:In a two-microelectrode voltage clamp assay with Xenopus laevis oocytes, a petroleum ether extract (100 μg/mL) of the resin of Boswellia thurifera (Burseraceae) potentiated GABA-induced chloride currents (IGABA) through receptors of the subtype α₁β₂γ₂s by 319.8% ± 79.8%. With the aid of HPLC-based activity profiling, ...

journal_title：Fitoterapia

authors： Rueda DC,Raith M,De Mieri M,Schöffmann A,Hering S,Hamburger M

更新日期：2014-12-01 00:00:00

abstract：:A new monodesmosidic spirostanol saponin, along with three known saponins was isolated from Agave macroacantha Zucc leaves. The structure of the new saponin was established as hecogenin-3-O-alpha-L-rhamnopyranosyl (1-->4) beta-D-xylopyranosyl (1-->3)[beta-D-glucopyranosyl (1-->2)] beta-D-glucopyranosyl (1-->4) beta-D-...

journal_title：Fitoterapia

authors： Eskander J,Lavaud C,Harakat D

更新日期：2010-07-01 00:00:00

abstract：:Three new xanthones, cylindroxanthones A-C (1-3), were isolated from the stem bark of Garcinia cylindrocarpa. The structures were established on the basis of spectroscopic analysis. The molecular structure of 1 was unequivocally confirmed by single-crystal X-ray diffraction analysis. These three xanthones were evaluat...

journal_title：Fitoterapia

authors： Sukandar ER,Ersam T,Fatmawati S,Siripong P,Aree T,Tip-pyang S

更新日期：2016-01-01 00:00:00

abstract：:Seven new lignan glycosides (1-3, 8-10, and 14) and 17 known compounds were isolated from the branches of Alangium kurzii Craib var. laxifolium. Their structures were established by spectroscopic analysis and circular dichroism (CD) and X-ray analysis. The isolated compounds were evaluated for their antibacterial acti...

journal_title：Fitoterapia

authors： Ren J,Xie YG,Huang YY,Zhu SL,Yan SK,Jin HZ,Zhang WD

更新日期：2017-09-01 00:00:00

abstract：:Six new monoterpenoid indole alkaloids, 19(E)-9-demethoxy-16-dehydroxylchitosenine-17-O- β-d-glucopyranoside (1), 19(E)-9,10-didemethoxy-16-dehydroxylchitosenine-17-O-β-d-gluco-pyranoside (2), 19(E)-9,10-didemethoxy-16-dehydroxyl-11-methoxychitosenine (3), 19(E)-9,10-didemethoxy-16-dehydroxyl-11-methoxychitosenine-17-...

journal_title：Fitoterapia

authors： Yang WX,Chen YF,Yang J,Huang T,Wu LL,Xiao N,Hao XJ,Zhang YH

更新日期：2018-01-01 00:00:00

abstract：:Rubus ideaus L., a member of the Rosaceae family, is popular for its distinctive flavor and attractive red color. In order to explore the functional factors possibly presented in the fruit, seven new benzofuran neolignans (1a/1b-3a/3b and 4b), together with one known neolignan 4a, were isolated from the fruit of R. id...

journal_title：Fitoterapia

authors： Zhou L,Xi YF,Wang W,Lin B,Wang XB,Huang XX,Song SJ

更新日期：2018-06-01 00:00:00

abstract：:Samarones A-D (1-4), four new acylphloroglucinol derivatives bearing a C17 alkyl side chain, along with five known analogues (5-9), were isolated from the leaves of Syzygium samarangense. Their structures were characterized on the basis of extensive spectroscopic methods including HR-ESI-MS/MS analysis. The cytotoxic ...

journal_title：Fitoterapia

authors： Yang J,Su JC,Lei XP,Huang XJ,Zhang DM,Ye WC,Wang Y

更新日期：2018-09-01 00:00:00

abstract：:Seven new lignans, cleistonkinins A- E (1-5), cleistonkisides A and B (6-7) were isolated from the fruits of Cleistanthus tonkinensis (Euphorbiaceae), together with five known aryltetralin lignans, cleisindoside B (8), cleistantoxin (9), cleisindoside D (10), neocleistantoxin (11) and polygamain (12). Their structures...

journal_title：Fitoterapia

authors： Nguyen LH,Vu VN,Phi Thi D,Tran VH,Litaudon M,Roussi F,Nguyen VH,Chau VM,Doan Thi Mai H,Pham VC

更新日期：2020-01-01 00:00:00

abstract：:Human carboxylesterase 1 (CES1), primarily expressed in the liver and adipocytes, is responsible for the hydrolysis of endogenous esters (such as cholesteryl esters and triacylglycerols) and the metabolism of xenobiotic esters (such as clopidogrel and oseltamivir), thus participates in physiological and pathological p...

journal_title：Fitoterapia

authors： Song PF,Zhu YD,Ma HY,Wang YN,Wang DD,Zou LW,Ge GB,Yang L

更新日期：2019-09-01 00:00:00

abstract：:The aim of the present research was to establish a comprehensive strategy to identify the metabolites of isoimperatorin after biotransformation with rat liver microsomes in vitro, and further describe metabolic kinetic characteristics of isoimperatorin and its main metabolites. Utilizing liquid chromatography with tim...

journal_title：Fitoterapia

authors： Chen TL,Zhang YB,Xu W,Kang TG,Yang XW

更新日期：2014-03-01 00:00:00

abstract：:A chemical investigation of the 80% EtOH extract of the aerial plant of Alstonia rupestris afforded four new monoterpenoid indole alkaloids, 6,7-epoxy-8-oxo-vincadifformine (1), 11-acetyl-6,7-epoxy-8-oxo-vincadifformine (2), 11-hydroxy-14-chloro-15-hydroxy-vincadifformine (3), and perakine N1,N4-dioxide (4), together ...

journal_title：Fitoterapia

authors： Zhang L,Hua Z,Song Y,Feng C

更新日期：2014-09-01 00:00:00

abstract：:Oil production from the seeds of Camellia oleifera Abel. causes a great waste of shells which contain a lot of bioactive components. The aim of this research was to isolate flavonoid from the shells of C. oleifera Abel. and evaluate its uses. The shells were extracted by 70% methanol, hydrolyzed by 2M hydrochloric aci...

journal_title：Fitoterapia

authors： Ye Y,Guo Y,Luo YT,Wang YF

更新日期：2012-12-01 00:00:00

abstract：:The antituberculosis activity of 14 natural azorellane and mulinane diterpenoids isolated from Azorella compacta, Azorella madreporica, Mulinum crassifolium, and Laretia acaulis, together with eight semisynthetic derivatives, was evaluated against two Mycobacterium tuberculosis strains. The natural azorellanes azorell...

journal_title：Fitoterapia

authors： Molina-Salinas GM,Bórquez J,Ardiles A,Said-Fernández S,Loyola LA,San-Martín A,González-Collado I,Peña-Rodríguez LM

更新日期：2010-01-01 00:00:00

abstract：:1,2-Dihydroxyanthraquinone (1) was isolated from the seed of Cassia obtusifolia through bioassay-guided fractionation. 1,2-Dihydroxyanthraquinone strongly inhibited the growth of Clostridium perfringens and Escherichia coli. Structure-activity relationship revealed that 1,4-dihydroxyanthraquinone (2) and 1,8-dihydroxy...

journal_title：Fitoterapia

authors： Sung BK,Kim MK,Lee WH,Lee DH,Lee HS

更新日期：2004-07-01 00:00:00

abstract：:A new cyclopeptide, pulvpeptin A (1), two pairs of norlignan lignanosides, tamariscinosides G and H (2, 3), together with five known compounds (4-8) were isolated from Selaginella pulvinata. The structures were elucidated by spectroscopic data and chemical degradation. The activity of tamariscinoside G (2) was evaluat...

journal_title：Fitoterapia

authors： Lv H,Li Y,Zhu M,Luo M,Qi J,Yu Z,Zhang H,Guo Y,Tong S,Li H,Yan J

更新日期：2020-06-01 00:00:00

abstract：:The effects of the essential oil of Eucalyptus tereticornis (EOET), especially the effects of its constituents alpha- and beta-pinene, were studied on rat trachea in vitro. In tracheal rings, EOET, alpha- or beta-pinene potentiated the contractions induced by acetylcholine (ACh). Contractions induced by K(+) (60mM) we...

journal_title：Fitoterapia

authors： Lima FJ,Brito TS,Freire WB,Costa RC,Linhares MI,Sousa FC,Lahlou S,Leal-Cardoso JH,Santos AA,Magalhães PJ

更新日期：2010-09-01 00:00:00

abstract：:This paper reports the results of an ethnobotanical survey of medicinal plants used by the Thari people of the Nara Desert, Sindh, Pakistan. Fifty-one plant species distributed across 28 families and 43 genera were discovered to have medicinal uses by local inhabitants of the Nara Desert. Twenty-one of those species a...

journal_title：Fitoterapia

authors： Qureshi R,Raza Bhatti G

更新日期：2008-09-01 00:00:00

abstract：:The secondary metabolite pattern of Eryngium tricuspidatum has been found to be dominated by C17 acetylene oxylipins, according to the chemistry reported in the literature for the genus Eryngium. Two new oxylipins, 11-acetoxy-falcarindiol (4) and 1,2-dihydro-11-acetoxy-falcarindiol (5) have been isolated, along with m...

journal_title：Fitoterapia

authors： Djebara A,Ciavatta ML,Mathieu V,Colin M,Bitam F,Carbone M,Gavagnin M

更新日期：2019-10-01 00:00:00

abstract：:A new compound, 3beta,25-epoxy-3alpha-hydroxy-22beta-isobutanoyloxyolean-12-ene-28-oic acid (1), and two known triterpenoids lantanilic acid (2) and camaric acid (3) were isolated from the stem and leaves of Lantana cujabensis. Their structures were elucidated by spectroscopic methods. The ethanol extracts did not sho...

journal_title：Fitoterapia

authors： Okunade AL,Lewis WH

更新日期：2004-06-01 00:00:00