Abstract:
:Two spiro paclitaxel-mimics consisting only of an oxetane D-ring and a C-13 side chain were designed and synthesized on the basis of analysis of structure-activity relationships (SAR) of paclitaxel. In vitro microtubule-stabilizing and antiproliferative assays indicated a moderate weaker activity of the mimics than paclitaxel, but which still represented the first example of simplified paclitaxel analogues with significant anti-tumor biological activity.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Chen XX,Gao F,Wang Q,Huang X,Wang Ddoi
10.1016/j.fitote.2013.10.015subject
Has Abstractpub_date
2014-01-01 00:00:00pages
111-5eissn
0367-326Xissn
1873-6971pii
S0367-326X(13)00292-Xjournal_volume
92pub_type
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