Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis.

abstract：:Diabetes is a worldwide healthy concern, which affects approximately 9% of the population. Tetrahydrocurcumin (THC) is the main metabolite of curcumin, which exerts the anti-diabetic activity. However, the underlying mechanism has not been clarified. In the research, we investigated whether THC could improve diabetes ...

journal_title：Fitoterapia

authors： Yuan T,Yin Z,Yan Z,Hao Q,Zeng J,Li L,Zhao J

更新日期：2020-10-01 00:00:00

abstract：:Goldenseal (Hydrastis canadensis) has emerged as one of the top five herbal supplements in the world-wide market. A convenient method for the determination of the quality and possible adulteration of goldenseal products is thin-layer chromatography (TLC). TLC analysis of 10 goldenseal samples using two solvent systems...

journal_title：Fitoterapia

authors： Govindan M,Govindan G

更新日期：2000-06-01 00:00:00

abstract：:Nagilactones are norditerpene dilactones isolated from the root bark of Podocarpus nagi. Although nagilactone E has been reported to show antifungal activities, its activity is weaker than that of antifungals on the market. Nagilactone E enhances the antifungal activity of phenylpropanoids such as anethole and isosafr...

journal_title：Fitoterapia

authors： Hayashi K,Yamaguchi Y,Ogita A,Tanaka T,Kubo I,Fujita KI

更新日期：2018-07-01 00:00:00

abstract：:In our previous study, RAPD (Random Amplified Polymorphic DNA) analysis revealed species-specific markers for three medicinal Echinacea species (Asteraceae): E. angustifolia DC., E. pallida (Nutt.) Nutt. and E. purpurea (L.) Moench. In the present work, we have converted a RAPD marker (750 bp) for E. purpurea into a S...

journal_title：Fitoterapia

authors： Adinolfi B,Chicca A,Martinotti E,Breschi MC,Nieri P

更新日期：2007-01-01 00:00:00

abstract：:Five new steroids, colebrin A-E (1-5) were isolated from the aerial parts of Clerodendrum colebrookianum. The structures of the new compounds were elucidated on the basis of spectral evidence. ...

journal_title：Fitoterapia

authors： Yang H,Wang J,Hou AJ,Guo YP,Lin ZW,Sun HD

更新日期：2000-12-01 00:00:00

abstract：:Phytochemical study on rhizomes of Beesia calthifolia resulted in the isolation of five new (1-5) and three known (6-8) cycloartane triterpenoids possessing a hemiketal or ketal group at C-24 from the EtOAc fraction of 95% ethanol extract. Their structures were determined by spectroscopic and chemical methods, especia...

journal_title：Fitoterapia

authors： Zheng DJ,Zhou J,Liu Q,Yao W,Zhang MZ,Shao BH,Mo JX,Zhou CX,Gan LS

更新日期：2015-06-01 00:00:00

abstract：:Glutamate-induced excitotoxicity is a key pathological mechanism in many neurological disease states. Ecdysterones derived from Rhaponticum carthamoides (Willd.) Iljin (RCI) have been shown to alleviate glutamate-induced neuronal damage; although their mechanism of action is unclear, some data suggest that they enhanc...

journal_title：Fitoterapia

authors： Wu J,Gao L,Shang L,Wang G,Wei N,Chu T,Chen S,Zhang Y,Huang J,Wang J,Lin R

更新日期：2017-06-01 00:00:00

abstract：:Three new secoiridoids, swermacrolactones A-C (1-3), together with fourteen known compounds were isolated from Swertia macrosperma. Their structures were elucidated based on extensive spectroscopic analyses (IR, UV, MS, 1D and 2D NMR). By anti-HBV assay on the Hep G 2.2.15 cell line in vitro, the most active compound,...

journal_title：Fitoterapia

authors： Wang HL,Geng CA,Ma YB,Zhang XM,Chen JJ

更新日期：2013-09-01 00:00:00

abstract：:Human carboxylesterase 1 (CES1), primarily expressed in the liver and adipocytes, is responsible for the hydrolysis of endogenous esters (such as cholesteryl esters and triacylglycerols) and the metabolism of xenobiotic esters (such as clopidogrel and oseltamivir), thus participates in physiological and pathological p...

journal_title：Fitoterapia

authors： Song PF,Zhu YD,Ma HY,Wang YN,Wang DD,Zou LW,Ge GB,Yang L

更新日期：2019-09-01 00:00:00

abstract：:Curcuphenol is a sesquiterpene isolated from sponges and plants having several significant biological activities. The present study explored its effect on cell proliferation and apoptosis in Caco-2 human colon cancer cells. It was demonstrated that curcuphenol in concentrations in the range of 29-116 µg/ml inhibited c...

journal_title：Fitoterapia

authors： Rodrigo G,Almanza GR,Cheng Y,Peng J,Hamann M,Duan RD,Akesson B

更新日期：2010-10-01 00:00:00

abstract：:Chemical examination of the ethanol extract of rhizomes of Iris tectorum led to the isolation and characterization of three new lignans, (7R,7'R,8S,8'S)-5'-methoxy-neo-olivil (1a), (7S,7'S,8R,8'R) -5'-methoxy-neo-olivil (1b), (7S,7'R,8S,8'S)-neo-olivil (2a), (7R,7'S,8R,8'R)-neo-olivil (2b), (7R,7'R,8S,8'S,7''S,8''S)-t...

journal_title：Fitoterapia

authors： Zhang CL,Wang Y,Liu YF,Liang D,Hao ZY,Luo H,Chen RY,Yu DQ

更新日期：2016-01-01 00:00:00

abstract：:Five new ursane-type triterpenoids, spicatusoids A-E (1, 3-6), and three known ones (2, 7, and 8), and a known oleanane-type triterpenoid (9) were isolated from the aerial parts of Clerodendranthus spicatus. Their structures were elucidated by spectroscopic methods. In particular, the structure of 3 including its abso...

journal_title：Fitoterapia

authors： Luo Y,Cheng LZ,Luo Q,Yan YM,Wang SM,Sun Q,Cheng YX

更新日期：2017-06-01 00:00:00

abstract：:Three new caged polyprenylated benzophenone derivatives named burlemarxiones D-F (1-3) were isolated from the hexane extract of Clusia burle-marxii trunks. Burlemarxione D (1) contains the tetracyclo[8.3.1.03,11.05,10]tetradecane core skeleton also observed for burlemarxione A, its probable immediate precursor. Howeve...

journal_title：Fitoterapia

authors： Ferraz CG,Ribeiro PR,Mendonça R,Silveira ER,Cruz FG

更新日期：2020-10-16 00:00:00

abstract：:Zuojinwan, which consists of Rhizoma coptidis-Evodia rutaecarpa powder (6:1,g/g), is a traditional Chinese medicine (TCM) prescription, clinically used for the treatment of gastro-intestinal disorders. This study compared the pharmacokinetics of dehydroevodiamine and coptisine, the main active ingredients in Zuojinwan...

journal_title：Fitoterapia

authors： Yan R,Wang Y,Shen W,Liu Y,Di X

更新日期：2011-12-01 00:00:00

abstract：:Crude CH2Cl2 extract from leaves of Piper laevicarpu (Piperaceae) displayed antitrypanosomal activity against trypomastigote forms of Trypanosoma cruzi (Y strain) and antimicrobial potential against Cryptococcus gattii (strain-type WM 178). Bioactivity-guided fractionation of crude extract afforded one new natural bio...

journal_title：Fitoterapia

authors： da Silva A Maciel D,Freitas VP,Conserva GA,Alexandre TR,Purisco SU,Tempone AG,Melhem MS,Kato MJ,Guimarães EF,Lago JH

更新日期：2016-06-01 00:00:00

abstract：:Panax ginseng is an indigenous medicinal herb and has traditionally been used among Asian population for relief of many human ailments. We investigated the prophylactic role of Korean P. ginseng extract (KG) against X-ray irradiation-induced emesis in an acute rat pica model. Rats were treated with KG (12.5, 25, 50 mg...

journal_title：Fitoterapia

authors： Balaji Raghavendran HR,Rekha S,Cho HK,Jang SS,Son CG

更新日期：2012-09-01 00:00:00

abstract：:Chemical investigation of the n-butanol extract from the methanol extract of the root bark of Artocarpus nobilis furnished four new prenylated flavonoids together with artonin E 2'-methylether (4), isoartonin E 2'-methylether (5), dihydroisoartonin E 2'-methylether (6), artonin V 2'-methylether (7), artobiloxanthone (...

journal_title：Fitoterapia

authors： Jayasinghe UL,Samarakoon TB,Kumarihamy BM,Hara N,Fujimoto Y

更新日期：2008-01-01 00:00:00

abstract：:The methanol extracts of Clematis papuasica leaves and stem bark and of Nauclea obversifolia leaves, stem and root barks showed awide spectrum of antibacterial activity which was increased on fractionation (petrol, dichloromethane, ethyl acetate), the ethyl acetate fractions being in all cases the most effective. None...

journal_title：Fitoterapia

authors： Khan MR,Kihara M,Omoloso AD

更新日期：2001-06-01 00:00:00

abstract：:Traditional Indonesian medicinal plants were screened for their inhibitory effects on the nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and for the antioxidant activity through the evaluation of free radical scavenging effect and reducing power. The results of screening indic...

journal_title：Fitoterapia

authors： Choi EM,Hwang JK

更新日期：2005-03-01 00:00:00

abstract：:Five new koumine-type alkaloids (1-5) along with six known ones were isolated from the roots of Gelsemium elegans. Their structures with absolute configurations were elucidated on the basis of NMR spectroscopy and electronic circular dichroism spectral analyses. The inhibitory effects of compounds 1-11 on the viabilit...

journal_title：Fitoterapia

authors： Zhang W,Zhang SY,Wang GY,Li NP,Chen MF,Gu JH,Zhang DM,Wang L,Ye WC

更新日期：2017-04-01 00:00:00

abstract：:The methanolic extract and total alkaloids of the aerial parts of Glaucium oxylobum exhibited good activity against Microsporum gypseum, Microsporum canis, Trichophyton mentagrophytes and Epidermophyton floccosum. Four alkaloids, dicentrine, glaucine, protopine, and alpha-allocryptopine, were identified as the compoun...

journal_title：Fitoterapia

authors： Morteza-Semnani K,Amin G,Shidfar MR,Hadizadeh H,Shafiee A

更新日期：2003-07-01 00:00:00

abstract：:The antifungal activity of methanolic extract and alkaloidal fraction of Berberis aetnensis against Candida species was investigated. The crude extract was active against Candida species, this activity being higher than that of the alkaloidal fraction and berberine. ...

journal_title：Fitoterapia

authors： Iauk L,Costanzo R,Caccamo F,Rapisarda A,Musumeci R,Milazzo I,Blandino G

更新日期：2007-02-01 00:00:00

abstract：:Epiberberine, a natural protoberberine from Coptis chinensis Franch., is a potential alkaloid for the treatment of a variety of chronic diseases. The aim of this study is to summarize recent advances in the multiple and potential therapeutic effects of epiberberine. High-quality researches published in last two decade...

journal_title：Fitoterapia

authors： Liu L,Li J,He Y

更新日期：2020-11-01 00:00:00

abstract：:The effects of the aqueous extract of the leaf of Euphrasia officinale on blood glucose levels in normal and alloxan-diabetic rats were investigated. The treatment of alloxan-induced diabetic rats brought down the raised glucose levels, while the extract was devoid of hypoglycemic effect in normal rats. ...

journal_title：Fitoterapia

authors： Porchezhian E,Ansari SH,Shreedharan NK

更新日期：2000-09-01 00:00:00

abstract：:A simple, sensitive and accurate liquid chromatographic method with photodiode-array detection was developed for determination of dehydroevodiamine with detection wavelength at 368 nm and column temperature at 30 degrees C. The separation was carried out on an Agilent Zorbax SB-C(18) column (250 mm x 4.6 mm, 5 microm)...

journal_title：Fitoterapia

authors： Zhao Y,Zhou X,Chen HG,Gong XJ,Cai ZW,Zhou CY

更新日期：2009-10-01 00:00:00

abstract：:In a two-microelectrode voltage clamp assay with Xenopus laevis oocytes, a petroleum ether extract (100 μg/mL) of the resin of Boswellia thurifera (Burseraceae) potentiated GABA-induced chloride currents (IGABA) through receptors of the subtype α₁β₂γ₂s by 319.8% ± 79.8%. With the aid of HPLC-based activity profiling, ...

journal_title：Fitoterapia

authors： Rueda DC,Raith M,De Mieri M,Schöffmann A,Hering S,Hamburger M

更新日期：2014-12-01 00:00:00

abstract：:Eight new dihydrobenzofuran neolignans, pinnatifidanin C I-VIII (1-8), together with two known analogs (9-10) were isolated from the seeds of Crataegus pinnatifida. Their structures were elucidated by spectroscopic analyses, especially 1D, 2D NMR and CD spectra. The cytotoxic activities of all isolates against human c...

journal_title：Fitoterapia

authors： Huang XX,Zhou CC,Li LZ,Peng Y,Lou LL,Liu S,Li DM,Ikejima T,Song SJ

更新日期：2013-12-01 00:00:00

abstract：:Although the bioactive compounds in goji have been thoroughly identified and quantified, little information is available on the bitter compounds in the berries, and no systematic works on the substances responsible for their bitterness have been performed. Herein, the substances contributing to the bitterness of berri...

journal_title：Fitoterapia

authors： Qian D,Chen J,Lai C,Kang L,Xiao S,Song J,Xie J,Huang L

更新日期：2020-06-01 00:00:00

abstract：:The aqueous root extract of Mimosa pudica dose dependently inhibited the hyaluronidase and protease activities of Indian snakes (Naja naja, Vipera russelii and Echis carinatus) venom. ...

journal_title：Fitoterapia

authors： Girish KS,Mohanakumari HP,Nagaraju S,Vishwanath BS,Kemparaju K

更新日期：2004-06-01 00:00:00

abstract：:Two new steroidal esters with an unusual framework, Sinkiangenorin A and B, a new organic acid glycoside, Sinkiangenorin C, and four known lignin compounds were isolated from the seeds of Ferula sinkiangensis. The structures of these compounds were established by spectroscopic analysis and single-crystal X-ray diffrac...

journal_title：Fitoterapia

authors： Li G,Li X,Cao L,Shen L,Zhu J,Zhang J,Wang J,Zhang L,Si J

更新日期：2014-09-01 00:00:00