Abstract：
:Three new secoiridoids, swermacrolactones A-C (1-3), together with fourteen known compounds were isolated from Swertia macrosperma. Their structures were elucidated based on extensive spectroscopic analyses (IR, UV, MS, 1D and 2D NMR). By anti-HBV assay on the Hep G 2.2.15 cell line in vitro, the most active compound, luteolin (9), inhibited the secretion of hepatitis B virus surface antigen (HBsAg) and hepatitis B virus e antigen (HBeAg) with IC50 values of 0.02 and 0.02 mM, respectively.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Wang HL,Geng CA,Ma YB,Zhang XM,Chen JJdoi
10.1016/j.fitote.2013.06.002subject
Has Abstractpub_date
2013-09-01 00:00:00pages
183-7eissn
0367-326Xissn
1873-6971pii
S0367-326X(13)00156-1journal_volume
89pub_type
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