当前位置： SCI文献检索 > FITOTERAPIA期刊下所有文献 > Novel anti-tumour barringenol-like triterpenoids from the husks of Xanthoceras sorbifolia Bunge and their three dimensional quantitative structure activity relationships analysis.

Novel anti-tumour barringenol-like triterpenoids from the husks of Xanthoceras sorbifolia Bunge and their three dimensional quantitative structure activity relationships analysis.

Abstract：

:The high edible oil content of Xanthoceras sorbifolia Bunge seeds contributes to its economic value. In this study, we analysed the barrigenol-like triterpenoids derived from X. sorbifolia husks. We also identified anti-tumour agents that could enhance the health benefits and medicinal value of X. sorbifolia. We isolated 10 barrigenol triterpenoids, including six new compounds (1-6) and four known compounds (7-10). New compounds 3 and 5 showed significant inhibitory activity against the proliferation of three human tumour cell lines, namely, HepG2, HCT-116 and U87-MG. We determined the relationship between the structures and inhibitory activity of 25 barrigenol triterpenoids and 15 penta-cyclic triterpenoids through analysis of three-dimensional quantitative structure activity relationships (3D-QSAR). The isolation of novel barrigenol derivatives with anti-tumour activity from X. sorbifolia implied that husks of this plant may be a good source of anti-tumour agents.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Wang D,Su D,Yu B,Chen C,Cheng L,Li X,Xi R,Gao H,Wang X

doi

10.1016/j.fitote.2016.11.002

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

51-60

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(16)30250-7

journal_volume

116

pub_type

杂志文章

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