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Lignans from the rhizomes of Iris tectorum.

Abstract：

:Chemical examination of the ethanol extract of rhizomes of Iris tectorum led to the isolation and characterization of three new lignans, (7R,7'R,8S,8'S)-5'-methoxy-neo-olivil (1a), (7S,7'S,8R,8'R) -5'-methoxy-neo-olivil (1b), (7S,7'R,8S,8'S)-neo-olivil (2a), (7R,7'S,8R,8'R)-neo-olivil (2b), (7R,7'R,8S,8'S,7''S,8''S)-threo-neo-olivil-4'-O-8-guaiacylglycerol ether (3), together with six known ones (4-9). Among them, compounds 1 and 2 were found to be racemic mixtures, respectively, which were verified by chiral HPLC analysis, compound 3 was a new sesquineolignan. The structures were elucidated on the basis of extensive spectroscopic analysis. To our knowledge, this is the first report of lignan constituents isolated from I. tectorum. All compounds were evaluated for their cytotoxicity against five human tumor cell lines and none of them displayed significant toxicity in tested cell lines at a concentration of 10 μM.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Zhang CL,Wang Y,Liu YF,Liang D,Hao ZY,Luo H,Chen RY,Yu DQ

doi

10.1016/j.fitote.2015.11.020

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

93-7

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(15)30127-1

journal_volume

108

pub_type

杂志文章

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