Abstract:
:Three new caged polyprenylated benzophenone derivatives named burlemarxiones D-F (1-3) were isolated from the hexane extract of Clusia burle-marxii trunks. Burlemarxione D (1) contains the tetracyclo[8.3.1.03,11.05,10]tetradecane core skeleton also observed for burlemarxione A, its probable immediate precursor. However, two additional rings are formed to produce an unprecedented complex-caged core skeleton. These additional rings could be formed by a radical cyclization reaction of one prenyl group at C-5 with C-1 and C-33, followed by oxidative dehydrogenation (rearomatization) or by an intramolecular [4 + 2] radical cycloaddition (Diels-Alder reaction), followed by an enolization reaction (rearomatization). Burlemarxiones E and F were isolated after methylation with diazomethane that was necessary to avoid the interconversion of the pair of β-diketones in tautomeric equilibrium. The proposed biosynthetic pathway for burlemarxiones D-F involves the condensation of either lavandulyl pyrophosphate or 2-(1-methylvinyl)-hexa-5-enyl pyrophosphate with the acylphloroglucinol derivative 6-benzoyl-5-hydroxy-5-cyclohexen-1,3-dione, followed by consecutive prenylation reactions. Therefore, Clusia burle-marxii reinforces the claim that the genus Clusia is an important source of sophisticated caged polyprenylated benzophenone derivatives.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Ferraz CG,Ribeiro PR,Mendonça R,Silveira ER,Cruz FGdoi
10.1016/j.fitote.2020.104760subject
Has Abstractpub_date
2020-10-16 00:00:00pages
104760eissn
0367-326Xissn
1873-6971pii
S0367-326X(20)30342-7pub_type
杂志文章相关文献
FITOTERAPIA文献大全abstract::The effects of aqueous extracts of Celastrus paniculatus (CP) seeds were shown to have antioxidant properties in rats. In the study reported here, we have investigated the free radical scavenging capacity of three aqueous extracts (WSEs) obtained from CP seeds: a room temperature extract (WF); a hot water extract (HF)...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/s0367-326x(03)00190-4
更新日期:2003-12-01 00:00:00
abstract::Total sennosides concentration is a very important factor when rhubarb and senna will be used as crude drugs. However, one-step analytical technique for total sennosides has not been reported except HPLC. An enzyme-linked immunosorbent assay (ELISA) for total sennosides concentration by using the combination of anti-s...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2008.09.004
更新日期:2009-01-01 00:00:00
abstract::This study examined the analgesic and anti-inflammatory actions of cis-mulberroside A isolated from Ramulus mori in several models of inflammatory pain in mice. Cis-mulberroside A (25 and 50mg/kg) given by p.o. route 30 min before challenge produced a dose-dependent inhibition of the acetic acid-induced pain and Evans...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2009.09.005
更新日期:2010-04-01 00:00:00
abstract::Two new xanthones: mangostanaxanthones I (3) and II (5) were isolated from the pericarp of Garcinia mangostana, along with four known xanthones: 9-hydroxycalabaxanthone (1), parvifolixanthone C (2), α-mangostin (4), and rubraxanthone (6). Their structures were elucidated on the basis of IR, UV, 1D, 2D NMR, and MS spec...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2014.08.014
更新日期:2014-10-01 00:00:00
abstract::Two new natural products, 5-O-[β-D-apiofuranosyl-(1→6)-β-d-glucopyranosyl]-1-isoindolinone (1) as well as N-(2E)-3-[(2S,3R)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]acryloylglycine (2), along with four known compounds (3-6), were isolated from the methanolic extract of Co...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2016.09.004
更新日期:2016-12-01 00:00:00
abstract::Curcuminoids possess powerful antioxidant activity as demonstrated in many chemical in vitro tests and in several in vivo trials. Nevertheless, the mechanism of this activity is not completely elucidated and studies on the in vivo antioxidant effects are still needed. Metabolomics may be used as an attractive approach...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2015.12.013
更新日期:2016-03-01 00:00:00
abstract::Five new benzylphenanthrenes, cremaphenanthrenes L-P (1-5) were isolated from the EtOAc-soluble extract of the tubers of Cremastra appendiculata. Their structures were elucidated based on the spectroscopic data and chemical methods. Compounds 1-5 were tested in vitro for their cytotoxic effects against colon (HCT-116)...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2015.03.003
更新日期:2015-06-01 00:00:00
abstract::Four new terpenoids, nemoralisins D-G (1-4), were isolated from the leaves and stems of Aphanamixis grandifolia, along with two known diterpenoids, nemoralisin C and nemoralisin. Among them, compound 1 is the first example of norsesquiterpenoid with δ-lactone moiety, and nemoralisins E-G (2-4), are a class of acyclic ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2013.10.014
更新日期:2014-01-01 00:00:00
abstract::Ailanthone (AIL) has many biological activities including antimalarial, antiviral and anticancer. Our previous study also found that AIL targets p23 against castration-resistant prostate cancer. In this report, the preclinical safety of AIL was evaluated by acute toxicity, subacute toxicity and toxicokinetics in mice....
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2019.04.016
更新日期:2019-07-01 00:00:00
abstract::Five new 8-9' linked neolignans conchigeranals A-E (1-5), together with three known compounds galanganal (6), galanganols A (7) and B (8), were isolated from the whole plant of Alpinia conchigera. Their structures were established by spectroscopic analysis, including 2D-NMR spectroscopic techniques. Cytotoxicities of ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2013.08.011
更新日期:2013-12-01 00:00:00
abstract::Infusions of Picrolemma sprucei roots, stems and leaves are used in traditional medicine throughout the Amazon region from the Guianas to Brazil and Peru in the treatment of gastritis, intestinal helminths and malaria. As there are no studies describing its mode of action in providing a gastroprotective effect, we det...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2014.02.008
更新日期:2014-06-01 00:00:00
abstract::A new phenylpropanoid glucoside and two new neolignans, namely (1S, 2R)-1-(3, 4, 5-trimethoxyphenyl)-3-(β-d-glucopyranosyloxy)-1, 2, 3-propanetriol (1), and (7R, 8R)-4, 7, 9, 9'-tetrahydroxy-3, 5, 3', 5'-tetramethoxy-8-4'-oxyneolignan 4-O-β-d-glucopyranoside (2) and 3', 9, 9'-trihydroxy-3, 5-dimethoxy-8-O-4'-neolignan...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2015.05.010
更新日期:2015-07-01 00:00:00
abstract::A new triterpene glycoside (1) along with the known intercedenside B (2) was isolated from the sea cucumber Pseudocolochirus violaceus. Glycoside 1 was elucidated as 3-O-{6-O-sodiumsulfate-3-O-methyl-beta-D-glucopyranosyl-(1-->3)-beta-D-xylopyranosyl-(1-->4)-[beta-D-xylopyranosyl(1-->2)]-beta-D-quinovopyranosyl-(1-->2...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2007.02.010
更新日期:2007-06-01 00:00:00
abstract::The objective of this study was to evaluate potential hepatoprotective capabilities of quercetin in relation to its modulation of the HO-1 and NOS-2 activities in an experimental model of fulminant liver failure. Liver insult was induced by in vivo administration of D-galactosamine (d-GalN, 400 mg/kg, i.p.) and lipopo...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2013.03.016
更新日期:2013-06-01 00:00:00
abstract::Diterpene alkaloids neoline (1), napelline (2), isotalatizidine (3), karakoline (4), senbusine A (5), senbusine C (6), aconitine (7) and taurenine (8) were identified from Aconitum napellus L. subsp. firmum, four (2-4, 6) of which are reported for the first time from this plant. The structures were determined by means...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2013.07.010
更新日期:2013-10-01 00:00:00
abstract::Two new ent-kaurene diterpenoids, 15α-acetoxyl-6,11α-epoxy-6α-hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7-olide (1), 15α-hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide (2), together with ten known compounds (5-14) were isolated from the leaves of Isodon rubescens. Their structures were elucidated mainly by ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2011.03.003
更新日期:2011-06-01 00:00:00
abstract::The isolation of jusmicranthin (1), a novel lignan from Justicia neesii, is reported. Compound 1 represents a new class of angularly fused arylnaphthalides having a gamma-hydroxylactone unit. ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/s0367-326x(00)00205-7
更新日期:2000-09-01 00:00:00
abstract::Two new steroidal esters with an unusual framework, Sinkiangenorin A and B, a new organic acid glycoside, Sinkiangenorin C, and four known lignin compounds were isolated from the seeds of Ferula sinkiangensis. The structures of these compounds were established by spectroscopic analysis and single-crystal X-ray diffrac...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2014.06.016
更新日期:2014-09-01 00:00:00
abstract::Anti-nociceptive and anti-oedematogenic effects of the aqueous extract from the leaves of Erythrina velutina were tested through experimental models of nociception in mice and paw oedema induced by carrageenin in rats. The extract (300 and 600 mg/kg) did not change the carrageenin-induced paw oedema. In the hot plate ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2005.07.002
更新日期:2005-12-01 00:00:00
abstract::Seven new lignan glycosides (1-3, 8-10, and 14) and 17 known compounds were isolated from the branches of Alangium kurzii Craib var. laxifolium. Their structures were established by spectroscopic analysis and circular dichroism (CD) and X-ray analysis. The isolated compounds were evaluated for their antibacterial acti...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2017.07.009
更新日期:2017-09-01 00:00:00
abstract::A new altersolanol derivative, 4-dehydroxyaltersolanol A (9), along with two known sesquiterpenoids, (S)-7'-hydroxyabscisic acid (7) and (S)-abscisic acid (8) were obtained from the endophytic fungus, Nigrospora oryzae, isolated from leaves of Combretum dolichopetalum. The host plant yielded six known compounds includ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2015.06.018
更新日期:2015-09-01 00:00:00
abstract::Eight new flavonoids daemoflavans A-H, including two dimeric proanthocyanidins (1 and 2), four flavans (3-6), two 2-arylbenzofurans (7 and 8), along with nine known compounds (9-17), were isolated from the fruit of Daemonorops draco. Their structures, including the absolute configurations, were elucidated by extensive...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2020.104549
更新日期:2020-06-01 00:00:00
abstract::Six Patagonian plants were screened for proteolytic activity: Colliguaja integerrima, Euphorbia collina, E. peplus and Stillingia patagonica (Euphorbiaceae), Philibertia gilliesii (Asclepiadaceae) and Grindelia chiloensis (Asteraceae). P. gilliesii extracts showed the highest specific activity, followed by S. patagoni...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/s0367-326x(03)00146-1
更新日期:2003-09-01 00:00:00
abstract::A new C(18)-phytosphingosine ceramide containing non-hydroxy fatty acid, armillaramide (1), has been isolated together with ergosterol peroxide from the fruiting bodies of the basidiomycete Armillaria mellea. Its structure was established as (2S,3S,4R)-2-hexadecanoylamino-octadecane-1,3,4-triol by spectroscopic and ch...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/s0367-326x(01)00319-7
更新日期:2001-12-01 00:00:00
abstract::Natural products chemistry is the discipline that lies at the heart of modern pharmacognosy. The field encompasses qualitative and quantitative analytical tools that range from spectroscopy and spectrometry to chromatography. Among other things, modern research on crude botanicals is engaged in the discovery of the ph...
journal_title:Fitoterapia
pub_type: 杂志文章,评审
doi:10.1016/j.fitote.2010.09.011
更新日期:2011-01-01 00:00:00
abstract::Ten new highly oxygenated lanostane triterpenoids, stereinones A-J (1-10), were isolated from the fruiting bodies of the basidiomycete Stereum sp. Compounds 3 and 4 are structurally characterized as intact lanostane-type triterpenoids containing unusual 1,2-diketone functionality at C-11 and C-12, while compound 10 is...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2017.11.020
更新日期:2018-03-01 00:00:00
abstract::Seventy-six plant species from 46 botanical families, traditionally used to treat intestinal diseases in Mbalmayo region are recorded. The local names and the way the plants are used are indicated. ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/s0367-326x(00)00288-4
更新日期:2001-03-01 00:00:00
abstract::The methanol extract and four triterpenoids isolated from the seeds of Caesalpinia bonducella showed a wide range of inhibiting activity against both gram-positive and gram-negative bacteria. ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/s0367-326x(01)00292-1
更新日期:2001-11-01 00:00:00
abstract::Flos Chrysanthemi (the flower of Chrysanthemum morifolium Ramat.) is widely used in China as a food and traditional Chinese medicine for many diseases. Luteolin and apigenin are two main bioactive components in Flos Chrysanthemi, and chrysoeriol and diosmetin are two methylated metabolites of luteolin in vivo by cathe...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2012.09.011
更新日期:2012-12-01 00:00:00
abstract::Fruit's decoctions of Passiflora edulis and P. foetida var. albiflora were evaluated for the inhibition of activity of gelatinase MMP-2 and MMP-9, two metallo-proteases involved in the tumour invasion, metastasis and angiogenesis. Both water extracts, at different concentrations, inhibited the enzymes. ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/s0367-326x(03)00023-6
更新日期:2003-04-01 00:00:00