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Rational quality assessment procedure for less-investigated herbal medicines: Case of a Congolese antimalarial drug with an analytical report.

Abstract：

:Herbal medicines are the most globally used type of medical drugs. Their high cultural acceptability is due to the experienced safety and efficiency over centuries of use. Many of them are still phytochemically less-investigated, and are used without standardization or quality control. Choosing SIROP KILMA, an authorized Congolese antimalarial phytomedicine, as a model case, our study describes an interdisciplinary approach for a rational quality assessment of herbal drugs in general. It combines an authentication step of the herbal remedy prior to any fingerprinting, the isolation of the major constituents, the development and validation of an HPLC-DAD analytical method with internal markers, and the application of the method to several batches of the herbal medicine (here KILMA) thus permitting the establishment of a quantitative fingerprint. From the constitutive plants of KILMA, acteoside, isoacteoside, stachannin A, and pectolinarigenin-7-O-glucoside were isolated, and acteoside was used as the prime marker for the validation of an analytical method. This study contributes to the efforts of the WHO for the establishment of standards enabling the analytical evaluation of herbal materials. Moreover, the paper describes the first phytochemical and analytical report on a marketed Congolese phytomedicine.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Tshitenge DT,Ioset KN,Lami JN,Ndelo-di-Phanzu J,Mufusama JP,Bringmann G

doi

10.1016/j.fitote.2016.03.012

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

189-95

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(16)30055-7

journal_volume

110

pub_type

杂志文章

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