3-Hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitory effect of Vitis vinifera.

abstract：:Three new steroidal glycosides (1-3) and a novel natural product 4 firstly obtained from a plant source, together with two known steroidal glycosides (5-6) have been isolated from the whole plant of Reineckia carnea. Their structures were determined by physicochemical properties and spectroscopic methods, and their cy...

journal_title：Fitoterapia

authors： Song X,Zhang D,He H,Li Y,Yang X,Deng C,Tang Z,Cui J,Yue Z

更新日期：2015-09-01 00:00:00

abstract：:Chiratone (1), a rare new chiratane type triterpenoid, together with five known triterpenoids were isolated from the rhizomes of Drynaria fortunei (Kunze) J. Sm. The structure was characterized as 20β-hydroxychiratan-22-one on the basis of extensive 1D and 2D NMR, and MS spectroscopic analyses, and was further confirm...

journal_title：Fitoterapia

authors： Liang YH,Wang W,Yu SW,Ye M,He XH,Gong NB,Lu Y,Khan IA,Guo DA

更新日期：2010-12-01 00:00:00

abstract：:Fractions prepared from the methanol extract of Buchholzia coriacea stem bark exhibited a high concentration-dependent antibacterial and antifungal activity compared to the standard antibiotics, ampicillin and tioconazole. In the brine shrimp lethality (BSL) assay, the methanol extract was found to be non-toxic with a...

journal_title：Fitoterapia

authors： Ajaiyeoba EO,Onocha PA,Nwozo SO,Sama W

更新日期：2003-12-01 00:00:00

abstract：:Zuojinwan, which consists of Rhizoma coptidis-Evodia rutaecarpa powder (6:1,g/g), is a traditional Chinese medicine (TCM) prescription, clinically used for the treatment of gastro-intestinal disorders. This study compared the pharmacokinetics of dehydroevodiamine and coptisine, the main active ingredients in Zuojinwan...

journal_title：Fitoterapia

authors： Yan R,Wang Y,Shen W,Liu Y,Di X

更新日期：2011-12-01 00:00:00

abstract：:Ten new geranylated 2-arylbenzofuran derivatives, including two monoterpenoid 2-arylbenzofurans (1 and 2), two geranylated 2-arylbenzofuran enantiomers (3a and 3b), and six geranylated 2-arylbenzofurans (4-9), along with four known 2-arylbenzofurans (10-13) were isolated from the root bark of Morus alba var. tatarica....

journal_title：Fitoterapia

authors： Zhang YL,Luo JG,Wan CX,Zhou ZB,Kong LY

更新日期：2014-01-01 00:00:00

abstract：:A screening was conducted with 26 plants collected in the Brazilian southeast region, to identify plant extracts with antibacterial properties against Aeromonas hydrophila, Bacillus subtilis, Pseudomonas aeruginosa and Staphylococcus aureus. Initially, the agar diffusion method was employed. Then, those extracts prese...

journal_title：Fitoterapia

authors： Oliveira DF,Pereira AC,Figueiredo HC,Carvalho DA,Silva G,Nunes AS,Alves DS,Carvalho HW

更新日期：2007-02-01 00:00:00

abstract：:Two new neo-clerodane diterpenoids have been isolated from the whole plant of Scutellaria barbata D. Don, and their structures were established by detailed spectral analyses as scutehenanine H (1) and 6-(2,3-epoxy-2-isopropyl-n-propoxyl)barbatin C (2). In vitro, the isolated two new compounds showed significant cytoto...

journal_title：Fitoterapia

authors： Dai SJ,Qu GW,Yu QY,Zhang DW,Li GS

更新日期：2010-10-01 00:00:00

abstract：:One new resveratrol analogue, 1-(3',4',5'-trimethoxyphenyl)-2-methoxy-2-(4″-methoxyphenyl)-ethane-1-ol (1), and two new prenylisoflavones, 4'-hydroxy-5,7-dimethoxy-6-(3-methyl-2-butenyl)-isoflavone (2), and derrubon 5-methyl ether (3), together with 17 known compounds including one new natural product, 5,7-dihydroxy-3...

journal_title：Fitoterapia

authors： Zhang HX,Lunga PK,Li ZJ,Dai Q,Du ZZ

更新日期：2014-06-01 00:00:00

abstract：:The fruit rind of Garcinia gummi-gutta, commonly known as Garcinia cambogia (syn.), is extensively used traditionally as a flavourant in fish curries due to its sharp sour taste. Additional ethnobotanical uses include its use as a digestive and a traditional remedy to treat bowel complaints, intestinal parasites and r...

journal_title：Fitoterapia

authors： Semwal RB,Semwal DK,Vermaak I,Viljoen A

更新日期：2015-04-01 00:00:00

abstract：:A weak estrogenicity of puerarin on reproductive organs was addressed in female rats. In short-term treatment, immature ovariectomized rats were injected with 0.7 mg/kg BW/day of puerarin, for 14 days. Puerarin did not increase uterus weights, endometrium and myometrium areas, and the percent of cornified cells (%Co),...

journal_title：Fitoterapia

authors： Malaivijitnond S,Tungmunnithum D,Gittarasanee S,Kawin K,Limjunyawong N

更新日期：2010-09-01 00:00:00

abstract：:Diterpene alkaloids neoline (1), napelline (2), isotalatizidine (3), karakoline (4), senbusine A (5), senbusine C (6), aconitine (7) and taurenine (8) were identified from Aconitum napellus L. subsp. firmum, four (2-4, 6) of which are reported for the first time from this plant. The structures were determined by means...

journal_title：Fitoterapia

authors： Kiss T,Orvos P,Bánsághi S,Forgo P,Jedlinszki N,Tálosi L,Hohmann J,Csupor D

更新日期：2013-10-01 00:00:00

abstract：:Solanum nigrum L. (also called as European black nightshade) has been traditionally used as folk medicine and food in some regions. Phytochemical investigations of the immature fruits of S. nigrum yielded five steroidal alkaloid glycosides (1-5), including an unprecedented nor-spirosolane type steroidal alkaloid with ...

journal_title：Fitoterapia

authors： Xiang L,Wang Y,Yi X,He X

更新日期：2019-09-01 00:00:00

abstract：:The phytochemical studies on the aerial parts of Digitalis davisiana Heywood led to the isolation of three undescribed phenylethanoid glycosides named as digidavisoside A (5), digidavisoside B (7), and davisoside (8), along with 9 known compounds, ferruginoside B (1), isolugrandoside (2), lugrandoside (3), maxoside (4...

journal_title：Fitoterapia

authors： Kutluay VM,Ishiuchi K,Makino T,Saracoglu I

更新日期：2019-06-01 00:00:00

abstract：:The pharmacological active genus Thymus L. comprises over 200 species. Besides its traditional pharmacological use, thyme may reduce the risk of caries disease, however, there is very little respective literature. The pharmacological effects can be attributed to the secondary plant metabolites. The composition of the ...

journal_title：Fitoterapia

authors： Schött G,Liesegang S,Gaunitz F,Gleß A,Basche S,Hannig C,Speer K

更新日期：2017-09-01 00:00:00

abstract：:Five rare sesquiterpene lactone dimers, vlasouliolides E-I, were isolated from Vladimiria souliei. Their chemical structures were elucidated by spectroscopic analysis. Furthermore, 2 and 4 were unambiguously confirmed by Cu-Kα X-ray crystallographic analysis. Compounds 1, 2, 4 and 5 exhibited significant anti-inflamma...

journal_title：Fitoterapia

authors： Wu ZL,Wang JX,Chen LP,Dong HY,Li HL,Zhang WD

更新日期：2018-03-01 00:00:00

abstract：:Goniothalamus macrophyllus (Blume) Hook. f. & Thoms. is a plant widely distributed in Malaysia. The aim of this study is to identify compounds from the roots of G. macrophyllus. The ground roots were extracted with aqueous methanol and partitioned sequentially with n-hexane, chloroform and butanol. Purification from t...

journal_title：Fitoterapia

authors： Abdullah N,Sahibul-Anwar H,Ideris S,Hasuda T,Hitotsuyanagi Y,Takeya K,Diederich M,Choo C

更新日期：2013-07-01 00:00:00

abstract：:Two new triterpenoid estersaponins (1, 2) were isolated from the leaves of Pittosporum tobira 'Variegata' (Thunb.) W. T. Aiton, along with one known saponin (3) and one known flavonoid glycoside (4). Their structures were established by different spectroscopic methods including 1D and 2D NMR, UV, as well as ESI-MS ana...

journal_title：Fitoterapia

authors： El Dib RA,Eskander J,Mohamed MA,Mohammed NM

更新日期：2015-10-01 00:00:00

abstract：:Isonuatigenin-3-O-beta-solatriose (1) was isolated from the roots of Solanum sisymbriifolium. Its structure was determined by spectroscopic methods. ...

journal_title：Fitoterapia

authors： Ferro EA,Alvarenga NL,Ibarrola DA,Hellión-Ibarrola MC,Ravelo AG

更新日期：2005-09-01 00:00:00

abstract：:Isorhynchophylline is one of the major alkaloids from the Uncaria hook possessing the effects of lowered blood pressure, vasodilatation and protection against ischemia-induced neuronal damage. However, the metabolic pathway of isorhynchophylline has not been fully reported yet. In this paper, the metabolism of isorhyn...

journal_title：Fitoterapia

authors： Chen F,Qi W,Sun J,Simpkins JW,Yuan D

更新日期：2014-09-01 00:00:00

abstract：:The flavonoid baicalein has been demonstrated to be an activator of the transcription factor Nrf2 in mammalian cell lines. We show that it further modulates the Nrf2 homolog SKN-1 in Caenorhabditis elegans and by this pathway mediates beneficial effects in the nematode: baicalein enhances the resistance of C. elegans ...

journal_title：Fitoterapia

authors： Havermann S,Humpf HU,Wätjen W

更新日期：2016-09-01 00:00:00

abstract：:Six Patagonian plants were screened for proteolytic activity: Colliguaja integerrima, Euphorbia collina, E. peplus and Stillingia patagonica (Euphorbiaceae), Philibertia gilliesii (Asclepiadaceae) and Grindelia chiloensis (Asteraceae). P. gilliesii extracts showed the highest specific activity, followed by S. patagoni...

journal_title：Fitoterapia

authors： Sequeiros C,López LM,Caffini NO,Natalucci CL

更新日期：2003-09-01 00:00:00

abstract：:The aim of the present research was to establish a comprehensive strategy to identify the metabolites of isoimperatorin after biotransformation with rat liver microsomes in vitro, and further describe metabolic kinetic characteristics of isoimperatorin and its main metabolites. Utilizing liquid chromatography with tim...

journal_title：Fitoterapia

authors： Chen TL,Zhang YB,Xu W,Kang TG,Yang XW

更新日期：2014-03-01 00:00:00

abstract：:Although the nature-identical chemical compounds are cheaper, they not always repeat biological activity of plant origin natural chemical compounds, often react allergies and resistance of microorganisms. The aim of this study was to investigate effects of Juniperus communis origin α-pinene with different enantiomeric...

journal_title：Fitoterapia

authors： Ložienė K,Švedienė J,Paškevičius A,Raudonienė V,Sytar O,Kosyan A

更新日期：2018-06-01 00:00:00

abstract：:Five new benzylphenanthrenes, cremaphenanthrenes L-P (1-5) were isolated from the EtOAc-soluble extract of the tubers of Cremastra appendiculata. Their structures were elucidated based on the spectroscopic data and chemical methods. Compounds 1-5 were tested in vitro for their cytotoxic effects against colon (HCT-116)...

journal_title：Fitoterapia

authors： Liu L,Li J,Zeng KW,Jiang Y,Tu PF

更新日期：2015-06-01 00:00:00

abstract：:The present study investigates the effect of in vivo administration of alcoholic extract of Tinospora cordifolia whole plant (ALTC) on the proliferation and myeloid differentiation of bone marrow hematopoietic precursor cells in mice bearing a transplantable T cell lymphoma of spontaneous origin designated as Dalton's...

journal_title：Fitoterapia

authors： Singh SM,Singh N,Shrivastava P

更新日期：2006-01-01 00:00:00

abstract：:Phytochemical study on rhizomes of Beesia calthifolia resulted in the isolation of five new (1-5) and three known (6-8) cycloartane triterpenoids possessing a hemiketal or ketal group at C-24 from the EtOAc fraction of 95% ethanol extract. Their structures were determined by spectroscopic and chemical methods, especia...

journal_title：Fitoterapia

authors： Zheng DJ,Zhou J,Liu Q,Yao W,Zhang MZ,Shao BH,Mo JX,Zhou CX,Gan LS

更新日期：2015-06-01 00:00:00

abstract：:Cajaninstilbene acid (CSA), a bioactive constituent isolated from pigeon pea leaves, exhibited neuroprotective activities in previous studies. The present study aims to evaluate the antidepressant effects of CSA by using behavioral despair models of tail suspension test (TST) and forced swimming test (FST), and a chro...

journal_title：Fitoterapia

authors： Zhang MD,Tao X,Pan RL,Wang LS,Li CC,Zhou YF,Liao YH,Chen SG,Chang Q,Liu XM

更新日期：2020-03-01 00:00:00

abstract：:The effect of schisandrin B (Sch B) on long-term ethanol-induced oxidative stress in various rat tissues was investigated. Long-term ethanol treatment increased reactive oxygen metabolites (ROM) level in plasma. The ethanol-induced oxidative stress was assessed by mitochondrial glutathione and α-tocopherol levels, ant...

journal_title：Fitoterapia

authors： Lam PY,Chiu PY,Leung HY,Chen N,Leong PK,Ko KM

更新日期：2010-12-01 00:00:00

abstract：:Chemical and biocatalytic synthesis of seven previously undescribed marchantin A ester derivatives has been presented. Chemical synthesis afforded three peresterified bisbibenzyl products (TE1-TE3), while enzymatic method, using lipase, produced regioselective monoester derivatives (ME1-ME4). The antiproliferative act...

journal_title：Fitoterapia

authors： Novakovic M,Simić S,Koračak L,Zlatović M,Ilic-Tomic T,Asakawa Y,Nikodinovic-Runic J,Opsenica I

更新日期：2020-04-01 00:00:00

abstract：:Extracts of Lantana camara var. aculeata leaves were studied for their phytochemical constituents and termiticidal effects against adult termite workers. The 5% chloroform extract was found to be significantly effective against termite workers. ...

journal_title：Fitoterapia

authors： Verma RK,Verma SK

更新日期：2006-09-01 00:00:00