3-Hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitory effect of Vitis vinifera.


:Activity-guided fractionation of the methanol extract of Vitis vinifera bark led to the isolation of epsilon-viniferin, ampelopcin A, vitisin A and vitisin B. Vitisin A and vitisin B showed a remarkable inhibitory activity against 3-hydroxy-3-methylglutaryl-Coenzyme A (HMG-CoA) reductase with IC50 value of 42.1 microM and 23.9 microM, respectively.






Koo M,Kim SH,Lee N,Yoo MY,Ryu SY,Kwon DY,Kim YS




Has Abstract


2008-04-01 00:00:00














  • Analgesic, anti-inflammatory, and CNS depressant activities of new constituents of Nepeta clarkei.

    abstract::Two new pentacyclic triterpenes named kirmanoic acid (1) and kurramanoic acid (2) have been isolated from the chloroform-soluble portion of the whole plant of Nepeta clarkei Hook. The structures of the two new compounds were assigned on the basis of their ¹H and ¹³C NMR spectra including two-dimensional NMR techniques...


    pub_type: 杂志文章


    authors: Hussain J,Ur Rehman N,Hussain H,Al-Harrasi A,Ali L,Rizvi TS,Ahmad M,Mehjabeen

    更新日期:2012-04-01 00:00:00

  • Pregnane alkaloids from Sarcococca hookeriana var. digyna.

    abstract::Fourteen pregnane-type steroidal alkaloids were isolated from the ethanolic extracts of whole Sarcococca hookeriana var. digyna plants. Their structures were elucidated on the basis of spectral data. Three of them were identified as new steroidal alkaloids: (S)-20-(N,N-dimethylamino)-16α,17α-epoxy-3β-methoxy-pregn-5-e...


    pub_type: 杂志文章


    authors: Zhang PZ,Wang F,Yang LJ,Zhang GL

    更新日期:2013-09-01 00:00:00

  • Sesquiterpenoids and γ-pyranone derivatives from the whole plant of Erigeron breviscapus and their neuroprotective effects.

    abstract::Four new sesquiterpenes (1-2, 6-7), a new pyranone glycoside (10) along with six known compounds, were isolated from the whole plant of Erigeron breviscapus. Their planar structures were elucidated using extensive spectroscopic analyses. Brevisterpene A (1) and brevisterpene B (2) were proved to be a pair of diastereo...


    pub_type: 杂志文章


    authors: Han S,Liu Y,Hou Z,Sun X,Yao G,Gao P,Li L,Song S

    更新日期:2019-10-01 00:00:00

  • Anti-Obesity effects of protopanaxdiol types of Ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet.

    abstract::Effects of protopanaxdiol (PDG) and protopanaxatriol (PTG) types of ginsenosides isolated from the leaves of American ginseng on porcine pancreatic lipase activity were determined in vitro. PDG inhibited the pancreatic lipase activity in a dose-dependent manner at the concentrations of 0.25-1mg/ml. It inhibited hydrol...


    pub_type: 杂志文章


    authors: Liu R,Zhang J,Liu W,Kimura Y,Zheng Y

    更新日期:2010-12-01 00:00:00

  • Ginsenoside rich fraction of Panax ginseng C.A. Meyer improve feeding behavior following radiation-induced pica in rats.

    abstract::Panax ginseng is an indigenous medicinal herb and has traditionally been used among Asian population for relief of many human ailments. We investigated the prophylactic role of Korean P. ginseng extract (KG) against X-ray irradiation-induced emesis in an acute rat pica model. Rats were treated with KG (12.5, 25, 50 mg...


    pub_type: 杂志文章


    authors: Balaji Raghavendran HR,Rekha S,Cho HK,Jang SS,Son CG

    更新日期:2012-09-01 00:00:00

  • Antihyperglycemic activity of Euphrasia officinale leaves.

    abstract::The effects of the aqueous extract of the leaf of Euphrasia officinale on blood glucose levels in normal and alloxan-diabetic rats were investigated. The treatment of alloxan-induced diabetic rats brought down the raised glucose levels, while the extract was devoid of hypoglycemic effect in normal rats. ...


    pub_type: 杂志文章


    authors: Porchezhian E,Ansari SH,Shreedharan NK

    更新日期:2000-09-01 00:00:00

  • Sesquiterpenoids from Artemisia argyi and their COXs inhibitory activities.

    abstract::Four new sesquiterpene lactones, named artemargyinolides A-D (1-4), and seven known sesquiterpenoids (5-11) were isolated from Artemisia argyi. Their structures were elucidated based on the extensive analysis of spectroscopic data. The absolute configuration of 1 was assigned by X-ray crystallographic analysis. Compou...


    pub_type: 杂志文章


    authors: Zhang LB,Lv JL

    更新日期:2019-11-01 00:00:00

  • Biological activity of some Patagonian plants.

    abstract::Citotoxicity (inhibition of cell division in fertilized eggs of Loxechinus albus) and general toxicity (using embryos of Artemia salina) of plants belonging to the genera Senecio, Deschampsia, Alstroemeria, Anarthrophyllum, Chloraea and Geranium were investigated. ...


    pub_type: 杂志文章


    authors: Cuadra P,Furrianca M,Oyarzún A,Yáñez E,Gallardo A,Fajardo V

    更新日期:2005-12-01 00:00:00

  • A new abietane diterpenoid from Ajuga ovalifolia var. calantha induces human lung epithelial A549 cell apoptosis by inhibiting SHP2.

    abstract::The Src-homology 2 domain-containing phosphatase 2 (SHP2), encoded by PTPN11, has been reported oncogenic tyrosine phosphatase associated with various tumors and played critical roles in many cell signaling events. Targeting SHP2 by small molecules may be a promising way for cancer therapy. Herein, a new abietane dite...


    pub_type: 杂志文章


    authors: Liu DM,Cao ZX,Yan HL,Li W,Yang F,Zhao WJ,Diao QC,Tan YZ

    更新日期:2020-03-01 00:00:00

  • Antituberculosis activity of natural and semisynthetic azorellane and mulinane diterpenoids.

    abstract::The antituberculosis activity of 14 natural azorellane and mulinane diterpenoids isolated from Azorella compacta, Azorella madreporica, Mulinum crassifolium, and Laretia acaulis, together with eight semisynthetic derivatives, was evaluated against two Mycobacterium tuberculosis strains. The natural azorellanes azorell...


    pub_type: 杂志文章


    authors: Molina-Salinas GM,Bórquez J,Ardiles A,Said-Fernández S,Loyola LA,San-Martín A,González-Collado I,Peña-Rodríguez LM

    更新日期:2010-01-01 00:00:00

  • Oleanene constituents of Lantana cujabensis.

    abstract::A new compound, 3beta,25-epoxy-3alpha-hydroxy-22beta-isobutanoyloxyolean-12-ene-28-oic acid (1), and two known triterpenoids lantanilic acid (2) and camaric acid (3) were isolated from the stem and leaves of Lantana cujabensis. Their structures were elucidated by spectroscopic methods. The ethanol extracts did not sho...


    pub_type: 杂志文章


    authors: Okunade AL,Lewis WH

    更新日期:2004-06-01 00:00:00

  • Determination of dehydroevodiamine in Evodia rutaecarpa (Juss.) Benth by high performance liquid chromatography and classification of the samples by using hierarchical clustering analysis.

    abstract::A simple, sensitive and accurate liquid chromatographic method with photodiode-array detection was developed for determination of dehydroevodiamine with detection wavelength at 368 nm and column temperature at 30 degrees C. The separation was carried out on an Agilent Zorbax SB-C(18) column (250 mm x 4.6 mm, 5 microm)...


    pub_type: 杂志文章


    authors: Zhao Y,Zhou X,Chen HG,Gong XJ,Cai ZW,Zhou CY

    更新日期:2009-10-01 00:00:00

  • Cytoprotective activities of hydroxycinnamic acid amides of serotonin against oxidative stress-induced damage in HepG2 and HaCaT cells.

    abstract::Hydroxycinnamic acid amides of serotonin (HCAAS) [caffeoylserotonin (compound 1), p-coumaroylserotonin (compound 2), and feruloylserotonin (compound 3)] are secondary metabolites produced in plants. The aim of this study was to investigate the cytoprotective effects of HCAAS based on intracellular reactive oxygen radi...


    pub_type: 杂志文章


    authors: Choi JY,Kim H,Choi YJ,Ishihara A,Back K,Lee SG

    更新日期:2010-12-01 00:00:00

  • 2-methyl-L-erythritol glycosides from Gardenia jasminoides.

    abstract::Two new glycosides, 2-methyl-L-erythritol-4-O-(6-O-trans-sinapoyl)-β-D-glucopyranoside (1) and 2-methyl-L-erythritol-1-O-(6-O-trans-sinapoyl)-β-D-glucopyranoside (2), along with two known triterpenoids (3-4), four quinic acid derivatives (5-8) and one flavonoid (9) were isolated from the fruit of Gardenia jasminoides....


    pub_type: 杂志文章


    authors: Yang L,Peng K,Zhao S,Zhao F,Chen L,Qiu F

    更新日期:2013-09-01 00:00:00

  • Hydroxysafflor yellow a inhibits lipopolysaccharide-induced inflammatory signal transduction in human alveolar epithelial A549 cells.

    abstract::Hydroxysafflor yellow A (HSYA) is an active ingredient obtained from the flower of Carthamus tinctorius L. The present study investigated the effects of HSYA on lipopolysaccharide (LPS)-induced inflammatory signal transduction in human alveolar epithelial A549 cells. A549 cells stimulated with LPS were incubated with ...


    pub_type: 杂志文章


    authors: Song L,Zhu Y,Jin M,Zang B

    更新日期:2013-01-01 00:00:00

  • Grapefruit: the last decade acquisitions.

    abstract::This review reports the last decade acquisitions on grapefruit. New coumarins and limonoids were isolated and characterised. The bioavailability of many drugs was tested with grapefruit juice (GJ) coadministration; the inhibition on cytochrome P450 seems due to a synergic action between flavonoids and coumarins. Antim...


    pub_type: 杂志文章,评审


    authors: Tirillini B

    更新日期:2000-08-01 00:00:00

  • Stimulation of dragon's blood accumulation in Dracaena cambodiana via fungal inoculation.

    abstract::Dragon's blood is a rare and precious traditional medicine used by different cultures since ancient times. However, studies on enhancing the rapid accumulation of dragon's blood in Dracaena cambodiana and determining its formation mechanism are unavailable. In this study, the activities of two fungi, namely, BJDC01 an...


    pub_type: 杂志文章


    authors: Cui JL,Wang CL,Guo SX,Xiao PG,Wang ML

    更新日期:2013-06-01 00:00:00

  • Accuracy, precision, and reliability of chemical measurements in natural products research.

    abstract::Natural products chemistry is the discipline that lies at the heart of modern pharmacognosy. The field encompasses qualitative and quantitative analytical tools that range from spectroscopy and spectrometry to chromatography. Among other things, modern research on crude botanicals is engaged in the discovery of the ph...


    pub_type: 杂志文章,评审


    authors: Betz JM,Brown PN,Roman MC

    更新日期:2011-01-01 00:00:00

  • A new arylnaphthalene lignan from Knema furfuracea.

    abstract::A new arylnaphthalene lignan, named furfuracin, was isolated from the leaves of Knema furfuracea (Myristicaceae), whereas 7 known compounds including (+)-trans-1,2-dihydrodehydroguaiaretic acid, fragransin A(2), biochanin A, gingkolic acid, anarcardic acid, 2-hydroxy-6-(12-phenyldodecyl)-benzoic acid and 2-hydroxy-6-(...


    pub_type: 杂志文章


    authors: Rangkaew N,Suttisri R,Moriyasu M,Kawanishi K

    更新日期:2009-09-01 00:00:00

  • Possible clues for camptothecin biosynthesis from the metabolites in camptothecin-producing plants.

    abstract::The plant derived camptothecin (CPT) is a pentacyclic pyrroloquinoline alkaloid with unique antitumor activity. Successive discoveries of new CPT-producing plants occurred in recent years due to market demands. The scattered distribution among angiosperms drew researchers' attention. The aim of this review is to appra...


    pub_type: 杂志文章,评审


    authors: Pu X,Zhang CR,Zhu L,Li QL,Huang QM,Zhang L,Luo YG

    更新日期:2019-04-01 00:00:00

  • Transcriptome analysis of Aconitum carmichaelii and exploration of the salsolinol biosynthetic pathway.

    abstract::Aconitum carmichaelii has been used in traditional Chinese medicine for treating various diseases for several thousand years. Based on the biosynthetic pathway of some alkaloids such as C19-diterpenoid alkaloids and obvious differences in alkaloid content between leaves of two A. carmichaelii varieties has been report...


    pub_type: 杂志文章


    authors: Yang Y,Hu P,Zhou X,Wu P,Si X,Lu B,Zhu Y,Xia Y

    更新日期:2020-01-01 00:00:00

  • Regulation of research: is it a drug trial or a supplement trial?

    abstract::Investigators and sponsors of dietary supplement research need to know the relevant regulatory requirements and how to comply with them. This brief review describes how research on dietary supplements is regulated by FDA. In general, whether an FDA sanctioned Investigational New Drug (IND) application is required for ...


    pub_type: 杂志文章,评审


    authors: Chen ST

    更新日期:2011-01-01 00:00:00

  • Fungal plasma membrane H⁺-ATPase inhibitory activity of o-hydroxybenzylated flavanones and chalcones from Uvaria chamae P. Beauv.

    abstract::In our ongoing efforts of finding natural fungicides to fight food and feed spoilage during production and storage, the antifungal potential of Ghanaian Uvaria chamae P. Beauv. was investigated, with emphasis on plant metabolites targeting the fungal plasma membrane (PM) H(+)-ATPase. Ethyl acetate extract of U. chamae...


    pub_type: 杂志文章


    authors: Kongstad KT,Wubshet SG,Kjellerup L,Winther AM,Staerk D

    更新日期:2015-09-01 00:00:00

  • Phenylpropanoids and neolignans from Smilax trinervula.

    abstract::A new phenylpropanoid glucoside and two new neolignans, namely (1S, 2R)-1-(3, 4, 5-trimethoxyphenyl)-3-(β-d-glucopyranosyloxy)-1, 2, 3-propanetriol (1), and (7R, 8R)-4, 7, 9, 9'-tetrahydroxy-3, 5, 3', 5'-tetramethoxy-8-4'-oxyneolignan 4-O-β-d-glucopyranoside (2) and 3', 9, 9'-trihydroxy-3, 5-dimethoxy-8-O-4'-neolignan...


    pub_type: 杂志文章


    authors: Shu J,Liang F,Liang J,Liang Y,Li F,Shao F,Liu R,Huang H

    更新日期:2015-07-01 00:00:00

  • Prenylated 4-phenylcoumarins and 4-alkylcoumarins from Kielmeyera argentea and their cytotoxic activity.

    abstract::Two new prenylated 4-phenylcoumarins, named kielcoumarin A (1) and kielcoumarin B (2) together with three known compounds, mammea B/BA (3), mammea B/BA cyclo F (4) and ferruol A (5), were obtained from stems and roots of Kielmeyera argentea (Calophyllaceae). Their structures were elucidated based on spectroscopic data...


    pub_type: 杂志文章


    authors: Boness HVM,Santos NAS,Costa IB,Queiroz CKL,Marques EJ,El-Bachá RS,Cruz FG

    更新日期:2021-01-27 00:00:00

  • Peniterpenoids A-C, new sesquiterpenoid metabolites from a wheat cyst nematode Penicillium janthinellum.

    abstract::Three new sesquiterpenoids, peniterpenoids A - C (1-3), together with six known metabolites (4-9) were isolated from an entomogenous fungus Penicillium janthinellum (LB1.20090001) collected from a wheat cyst nematode. The structures of the new compounds were elucidated based on NMR and HRESIMS spectroscopic analyses. ...


    pub_type: 杂志文章


    authors: Liu S,Fan W,Ren J,Wang W,Liu X,Liang Y,Wei T,Li E

    更新日期:2021-01-01 00:00:00

  • Nepetalactone content in shoot cultures of three endemic Nepeta species and the evaluation of their antimicrobial activity.

    abstract::Rapid micropropagation of Nepeta rtanjensis, N. sibirica and N. nervosa was performed. Qualitative and quantitative nepetalactone content in methanol extracts of in vitro grown plants was analysed by reverse-phase HPLC coupled with UV and MS detection. Only trans,cis-nepetalactone was detected in shoots of N. rtanjens...


    pub_type: 杂志文章


    authors: Nestorović J,Misić D,Siler B,Soković M,Glamoclija J,Cirić A,Maksimović V,Grubisić D

    更新日期:2010-09-01 00:00:00

  • Coumarins from Peucedanum luxurians.

    abstract::Ten coumarins were isolated from Peucedanum luxurians. The rare coumarins stenocarpin, stenocarpin isobutyrate, officinalin, officinalin isobutyrate, 8-methoxypeucedanin and the known xanthotoxin, isoimperatorin, bergaptene, peucedanin and cnidilin were isolated. All isolated compound were identified by means of spect...


    pub_type: 杂志文章


    authors: Chinou I,Widelski J,Fokialakis N,Magiatis P,Glowniak K

    更新日期:2007-09-01 00:00:00

  • Antimicrobial activity of the Derris elliptica, Derris indica and Derris trifoliata extractives.

    abstract::Various parts of Derris elliptica, Derris indica and Derris trifoliata on fractionation with a number of solvents (petrol, dichloromethane, ethyl acetate, butanol and methanol) gave fractions which demonstrated a varied level of broad spectrum antibacterial activity. Good activity was exhibited by the methanol fractio...


    pub_type: 杂志文章


    authors: Khan MR,Omoloso AD,Barewai Y

    更新日期:2006-06-01 00:00:00

  • Acylphloroglucinol derivatives from the leaves of Syzygium samarangense and their cytotoxic activities.

    abstract::Samarones A-D (1-4), four new acylphloroglucinol derivatives bearing a C17 alkyl side chain, along with five known analogues (5-9), were isolated from the leaves of Syzygium samarangense. Their structures were characterized on the basis of extensive spectroscopic methods including HR-ESI-MS/MS analysis. The cytotoxic ...


    pub_type: 杂志文章


    authors: Yang J,Su JC,Lei XP,Huang XJ,Zhang DM,Ye WC,Wang Y

    更新日期:2018-09-01 00:00:00