The chemical composition of the pharmacologically active Thymus species, its antibacterial activity against Streptococcus mutans and the antiadherent effects of T. vulgaris on the bacterial colonization of the in situ pellicle.

Abstract:

:The pharmacological active genus Thymus L. comprises over 200 species. Besides its traditional pharmacological use, thyme may reduce the risk of caries disease, however, there is very little respective literature. The pharmacological effects can be attributed to the secondary plant metabolites. The composition of the essential oil and the polyphenols is important for the evaluation of the pharmacological activity. Nevertheless, there are no studies regarding a comparative analysis of the different pharmacological thyme species. In the present study, four different pharmacology Thymus species were cultivated under comparable conditions, and the volatile compounds as well as the polyphenols were characterized. In addition, the in vitro antibacterial activity against S. mutans, one of the primary cariogenic bacterial species, as well as of the essential oil and of the polyphenols were investigated. Furthermore, the bacterial viability and its effect on the initial bacterial adhesion under oral conditions were evaluated in situ for the essential oil and the polyphenols. By GC-MS, 69 volatile compounds, and by LC-DAD-MS/MS, 46 polyphenols could be identified. The comprehensive examination of the essential oils and the polyphenols revealed that the main compounds were equal. However, the yield of the essential oil and the polyphenol content differed clearly. The essential oils of the four investigated Thymus species exhibited an antibacterial activity against S. mutans in vitro, in contrast to the polyphenols of T. vulgaris. Rinsing with polyphenol-rich infusions reduced the initial bacterial colonization while the essential oil inhibited the bacterial growth on dental enamel in situ.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Schött G,Liesegang S,Gaunitz F,Gleß A,Basche S,Hannig C,Speer K

doi

10.1016/j.fitote.2017.07.005

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

118-128

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(17)30666-4

journal_volume

121

pub_type

杂志文章
  • New steroids from Clerodendrum colebrookianum.

    abstract::Five new steroids, colebrin A-E (1-5) were isolated from the aerial parts of Clerodendrum colebrookianum. The structures of the new compounds were elucidated on the basis of spectral evidence. ...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/s0367-326x(00)00223-9

    authors: Yang H,Wang J,Hou AJ,Guo YP,Lin ZW,Sun HD

    更新日期:2000-12-01 00:00:00

  • Suppressive effects of polyozellin on endothelial protein C receptor shedding via inhibiting TACE activity and MAP kinases.

    abstract::Beyond its role in the activation of protein C, the endothelial cell protein C receptor (EPCR) plays an important role in the cytoprotective pathway. EPCR can be shed from the cell surface, which is mediated by tumor necrosis factor-α converting enzyme (TACE). Polyozellin, a major constituent of a Korea edible mushroo...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/j.fitote.2015.11.005

    authors: Lee W,Yang EJ,Park DH,Bae JS

    更新日期:2016-01-01 00:00:00

  • Indoleacetic acid derivatives from the seeds of Ziziphus jujuba var. spinosa.

    abstract::A pair of diastereoisomers, the N-glycosylated derivatives of dioxindole-3-hydroxy-3-acetic acid 1-2, and their conjugates with flavonoids 3-8, was isolated from the seeds of Ziziphus jujuba var. spinosa. Their structures were elucidated by NMR spectroscopic analyses, and the absolute configurations were determined by...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/j.fitote.2014.09.001

    authors: Li M,Wang Y,Tsoi B,Jin XJ,He RR,Yao XJ,Dai Y,Kurihara H,Yao XS

    更新日期:2014-12-01 00:00:00

  • Lycocasuarines I-Q, new Lycopodium alkaloids isolated from Lycopodiastrum casuarinoides.

    abstract::Lycocasuarines I-Q (1-9), nine new lycodine-type Lycopodium alkaloids were isolated from the aerial parts of Lycopodiastrum casuarinoides (Spring) Holub ex R.D.Dixit. Their structures were unambiguously determined via extensive spectroscopic analyses, including HRESIMS, NMR, and electronic circular dichroism (ECD). Th...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/j.fitote.2019.03.027

    authors: Zhu XL,Wang LL,Shi ZH,Xia D,Zhou ZB,Pan K

    更新日期:2019-04-01 00:00:00

  • Two new minor cyclopeptides from Sagina japonica (Caryophyllaceae).

    abstract::Two new minor cyclopeptides, named japonicin A (1), japonicin B (2), were isolated from the whole plants of Sagina japonica (Caryophyllaceae). Their structures were determined as cyclo-(Pro(1)-Pro(2)-Leu(2)-Leu(1)-Phe(2)-Pro(3)-Gly-Ser-Phe(1)) (1) and cyclo-(Pro(1)-Ile-Tyr-Asp-Pro(2)-Phe(2)-Pro(3)-Phe(1)) (2) on the b...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/j.fitote.2009.01.004

    authors: Jia AQ,Tan NH,Zhou J

    更新日期:2009-04-01 00:00:00

  • Ginsenoside rich fraction of Panax ginseng C.A. Meyer improve feeding behavior following radiation-induced pica in rats.

    abstract::Panax ginseng is an indigenous medicinal herb and has traditionally been used among Asian population for relief of many human ailments. We investigated the prophylactic role of Korean P. ginseng extract (KG) against X-ray irradiation-induced emesis in an acute rat pica model. Rats were treated with KG (12.5, 25, 50 mg...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/j.fitote.2012.04.008

    authors: Balaji Raghavendran HR,Rekha S,Cho HK,Jang SS,Son CG

    更新日期:2012-09-01 00:00:00

  • A HPTLC densitometric method for the determination of aloeverose in Aloe vera gel.

    abstract::Aloe vera gel is a familiar ingredient in a range of widely available and advertisement healthcare and cosmetic products. As to date there are no documented reports on the standardization of A. vera gel and the following study is an attempt in this direction. A. vera gel was evaluated for its aloeverose content for th...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/j.fitote.2009.09.001

    authors: Lobo R,Prabhu KS,Shirwaikar A,Ballal M,Balachandran C,Shirwaikar A

    更新日期:2010-06-01 00:00:00

  • Linarin, a selective acetylcholinesterase inhibitor from Mentha arvensis.

    abstract::Linarin (acacetin-7-O-beta-d-rutinoside) from the flower extract of Mentha arvensis showed selective dose dependent inhibitory effect on acetylcholinesterase. ...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/j.fitote.2006.05.002

    authors: Oinonen PP,Jokela JK,Hatakka AI,Vuorela PM

    更新日期:2006-09-01 00:00:00

  • Native Australian plant extracts differentially induce Collagen I and Collagen III in vitro and could be important targets for the development of new wound healing therapies.

    abstract::Australian native plants have a long history of therapeutic use in indigenous cultures, however, they have been poorly studied scientifically. We analysed the effects of 14 plant derived compounds from the species Pilidiostigma glabrum, Myoporum montanum, Geijera parviflora, and Rhodomyrtus psidioides for their potent...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/j.fitote.2015.12.010

    authors: Adams DH,Shou Q,Wohlmuth H,Cowin AJ

    更新日期:2016-03-01 00:00:00

  • New C-methylated flavonoids and α-pyrone derivative from roots of Talinum triangulare growing in Nigeria.

    abstract::The first chemical examination of roots of the traditionally used medicinal plant Talinum triangulare (Portulacaceae) from Nigeria led to the isolation of two new C-methylated flavonoids, 5,6-dimethoxy-7-hydroxy-8-methyl-flavone (1), 5,6-dimethoxy-8-methyl-2-phenyl-7H-1-benzopyran-7-one (2), and one new α-pyrone deriv...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/j.fitote.2016.01.002

    authors: Umeokoli BO,Muharini R,Okoye FB,Ajiwe VI,Akpuaka MU,Lin W,Liu Z,Proksch P

    更新日期:2016-03-01 00:00:00

  • A postmenopause-like model of ovariectomized Wistar rats to identify active principles of Erythrina lysistemon (Fabaceae).

    abstract::To determine whether the two major compounds of Erythrina lysistemon are active principles accounting for Erythrina estrogenic effects, we used a postmenopause-like model of ovariectomized Wistar rats to evaluate their effects on some menopausal problems. Ovariectomized rats were orally treated either with compound 1 ...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/j.fitote.2011.05.009

    authors: Mvondo MA,Njamen D,Fomum ST,Wandji J,Vollmer G

    更新日期:2011-10-01 00:00:00

  • Studies on antidepressant and antinociceptive effects of ethyl acetate extract from Piper laetispicum and structure-activity relationship of its amide alkaloids.

    abstract::Piper laetispicum C.DC. (Piperaceae), is an endemic climbing, glabrous plant distributed in the southern part of China. A novel alkaloid amide, Laetispicine, from it has been proven to possess antidepressant activity. In this present study, antidepressant and antinociceptive effects of the ethyl acetate extract (EAE) ...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/j.fitote.2011.07.006

    authors: Xie H,Yan MC,Jin D,Liu JJ,Yu M,Dong D,Cai CC,Pan SL

    更新日期:2011-10-01 00:00:00

  • Anti-inflammatory and anti-ulcer activity of Calligonum comosum in rats.

    abstract::The 10% ethanol extract of the aerial parts of Calligonum comosum (50--400 mg/kg, i.p.) significantly reduced the increase in hind paw oedema induced by carrageenan in rats. Following sub-acute oral administration of the extract (50 and 100 mg/kg, daily for 14 days), a significant anti-inflammatory activity in the cot...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/s0367-326x(01)00271-4

    authors: Liu XM,Zakaria MN,Islam MW,Radhakrishnan R,Ismail A,Chen HB,Chan K,Al-Attas A

    更新日期:2001-06-01 00:00:00

  • Antimicrobial activity of Securinega leucopyrus.

    abstract::Extracts of the leaves of Securinega leucopyrus exhibited a broad spectrum of antimicrobial activity. ...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/s0367-326x(01)00341-0

    authors: Bakshu LM,Jeevan Ram A,Venkata Raju R

    更新日期:2001-12-01 00:00:00

  • New isocoumarins and alkaloid from Chinese insect medicine, Eupolyphaga sinensis Walker.

    abstract::Two new isocoumarins (1 and 2), a new alkaloid (3), and a known N-acetyldopamine dimer (4) were isolated from the ethyl acetate extract of Chinese insect medicine Eupolyphaga sinensis. Their structures were elucidated on the basis of detailed spectroscopic investigations, such as 1D- and 2D NMR spectroscopy, as well a...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/j.fitote.2012.06.005

    authors: Jiang HL,Luo XH,Wang XZ,Yang JL,Yao XJ,Crews P,Valeriote FA,Wu QX

    更新日期:2012-10-01 00:00:00

  • Cytotoxic and antioxidant dihydrobenzofuran neolignans from the seeds of Crataegus pinnatifida.

    abstract::Eight new dihydrobenzofuran neolignans, pinnatifidanin C I-VIII (1-8), together with two known analogs (9-10) were isolated from the seeds of Crataegus pinnatifida. Their structures were elucidated by spectroscopic analyses, especially 1D, 2D NMR and CD spectra. The cytotoxic activities of all isolates against human c...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/j.fitote.2013.09.011

    authors: Huang XX,Zhou CC,Li LZ,Peng Y,Lou LL,Liu S,Li DM,Ikejima T,Song SJ

    更新日期:2013-12-01 00:00:00

  • Antimicrobial activity of Clematis papuasica and Nauclea obversifolia.

    abstract::The methanol extracts of Clematis papuasica leaves and stem bark and of Nauclea obversifolia leaves, stem and root barks showed awide spectrum of antibacterial activity which was increased on fractionation (petrol, dichloromethane, ethyl acetate), the ethyl acetate fractions being in all cases the most effective. None...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/s0367-326x(01)00258-1

    authors: Khan MR,Kihara M,Omoloso AD

    更新日期:2001-06-01 00:00:00

  • Essential oil of Lindera neesiana fruit: chemical analysis and its potential use in topical applications.

    abstract::The composition of the essential oil of Lindera neesiana Kurz fruit was examined by GC-MS, (1)H, (13)C and bidimensional NMR techniques (HMQC, HMBC, COSY, TOCSY). Forty compounds were identified, representing approximately 86% of the oil: Z-citral (15.08%), E-citral (11.89%), eucalyptol (8.75%), citronellal (6.72%), a...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/j.fitote.2009.06.017

    authors: Comai S,Dall'Acqua S,Grillo A,Castagliuolo I,Gurung K,Innocenti G

    更新日期:2010-01-01 00:00:00

  • Five novel naphthylisoquinoline alkaloids with growth inhibitory activities against human leukemia cells HL-60, K562 and U937 from stems and leaves of Ancistrocladus tectorius.

    abstract::Two new 7,6'-coupled naphthylisoquinolines, namely ancistrotectorines A (1) and B (2), two new 5,3'-coupled naphthylisoquinolines, namely ancistrotectorines C (3) and D (4), and one new 7,8-coupled naphthylisoquinoline, namely ancistrotectorine E (5), together with 9 known naphthylisoquinoline alkaloids, hamatine (6),...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/j.fitote.2013.09.010

    authors: Jiang C,Li ZL,Gong P,Kang SL,Liu MS,Pei YH,Jing YK,Hua HM

    更新日期:2013-12-01 00:00:00

  • Triglycerides from Urena lobata.

    abstract::Two triglycerides, both bearing polyunsaturated fatty acid residues, were isolated from the hexane extract of Urena lobata. One of them is characterized by the presence of three different polyunsaturated fatty acids. Their structures were studied with spectral methods. ...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/j.fitote.2006.03.010

    authors: Morelli CF,Cairoli P,Speranza G,Alamgir M,Rajia S

    更新日期:2006-06-01 00:00:00

  • Chemical constituents from Aphanamixis grandifolia.

    abstract::Four new terpenoids, nemoralisins D-G (1-4), were isolated from the leaves and stems of Aphanamixis grandifolia, along with two known diterpenoids, nemoralisin C and nemoralisin. Among them, compound 1 is the first example of norsesquiterpenoid with δ-lactone moiety, and nemoralisins E-G (2-4), are a class of acyclic ...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/j.fitote.2013.10.014

    authors: Zhang R,He HP,Di YT,Li SL,Zuo GY,Zhang Y,Hao XJ

    更新日期:2014-01-01 00:00:00

  • New depsidones and xanthone from the roots of Garcinia schomburgkiana.

    abstract::Two new depsidones, schomburgdepsidones A and B (1 and 2), and one new xanthone, schomburgxanthone A (3), together with eight known compounds (4-11) were isolated from the roots of Garcinia schomburgkiana. Their chemical structures were established on the basis of spectroscopic analysis. The in vitro cytotoxicity of a...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/j.fitote.2016.04.012

    authors: Sukandar ER,Siripong P,Khumkratok S,Tip-Pyang S

    更新日期:2016-06-01 00:00:00

  • Alkaloids from Sarcomelicope megistophylla.

    abstract::Two new alkaloids were isolated from the bark of Sarcomelicope megistophylla. Cyclomegistine B (1), a new quinolone alkaloid, that possesses a rare cyclobuta[b]quinoline ring system and sarcomejine B (2) which is a quinolone alkaloid with an unusual side chain. The structure of both compounds was elucidated on the bas...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/j.fitote.2006.10.003

    authors: Mitaku S,Fokialakis N,Magiatis P,Tillequin F

    更新日期:2007-02-01 00:00:00

  • Anti-inflammatory lignanamides from the roots of Solanum melongena L.

    abstract::Four new lignanamides, melongenamides A-D (1-4), together with six known ones (5-10), were isolated from the roots of Solanum melongena L. Their structures were elucidated on the basis of 1D and 2D NMR experiments and by comparison of their spectroscopic and physical data with the literature values. Compounds 2-8 exhi...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/j.fitote.2014.07.012

    authors: Sun J,Gu YF,Su XQ,Li MM,Huo HX,Zhang J,Zeng KW,Zhang Q,Zhao YF,Li J,Tu PF

    更新日期:2014-10-01 00:00:00

  • Grapefruit: the last decade acquisitions.

    abstract::This review reports the last decade acquisitions on grapefruit. New coumarins and limonoids were isolated and characterised. The bioavailability of many drugs was tested with grapefruit juice (GJ) coadministration; the inhibition on cytochrome P450 seems due to a synergic action between flavonoids and coumarins. Antim...

    journal_title:Fitoterapia

    pub_type: 杂志文章,评审

    doi:10.1016/s0367-326x(00)00176-3

    authors: Tirillini B

    更新日期:2000-08-01 00:00:00

  • Sulfur-containing iridoid glucosides from Paederia scandens.

    abstract::A new sulfur-containing iridoid glucoside, named paederoside B, was isolated from the stems of Paederia scandens. The structure of the new compound was elucidated as paederosidyl paederosidate by spectral evidence. ...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/j.fitote.2006.05.003

    authors: Zou X,Peng S,Liu X,Bai B,Ding L

    更新日期:2006-07-01 00:00:00

  • Anti-nociceptive activity of the aqueous extract of Erythrina velutina leaves.

    abstract::Anti-nociceptive and anti-oedematogenic effects of the aqueous extract from the leaves of Erythrina velutina were tested through experimental models of nociception in mice and paw oedema induced by carrageenin in rats. The extract (300 and 600 mg/kg) did not change the carrageenin-induced paw oedema. In the hot plate ...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/j.fitote.2005.07.002

    authors: Marchioro M,Blank Mde F,Mourão RH,Antoniolli AR

    更新日期:2005-12-01 00:00:00

  • Cytoprotectivity of Prunella vulgaris on doxorubicin-treated rat cardiomyocytes.

    abstract::The cardioprotective effect of Prunella vulgaris ethylacetate fraction (PVEF) and its constituent rosmarinic acid (RA) was evaluated on isolated rat cardiomyocytes subjected to doxorubicin-induced oxidative stress. The cytoprotectivities of PVEF and RA were concentration-dependent in the range of 0.005 to 0.05 mg/ml a...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/j.fitote.2005.04.019

    authors: Psotová J,Chlopcíková S,Miketová P,Simánek V

    更新日期:2005-09-01 00:00:00

  • Isolation and free radical scavenging activities of a novel biflavonoid from the shells of Camellia oleifera Abel.

    abstract::Oil production from the seeds of Camellia oleifera Abel. causes a great waste of shells which contain a lot of bioactive components. The aim of this research was to isolate flavonoid from the shells of C. oleifera Abel. and evaluate its uses. The shells were extracted by 70% methanol, hydrolyzed by 2M hydrochloric aci...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/j.fitote.2012.09.006

    authors: Ye Y,Guo Y,Luo YT,Wang YF

    更新日期:2012-12-01 00:00:00

  • Analgesic, anti-inflammatory, and CNS depressant activities of new constituents of Nepeta clarkei.

    abstract::Two new pentacyclic triterpenes named kirmanoic acid (1) and kurramanoic acid (2) have been isolated from the chloroform-soluble portion of the whole plant of Nepeta clarkei Hook. The structures of the two new compounds were assigned on the basis of their ¹H and ¹³C NMR spectra including two-dimensional NMR techniques...

    journal_title:Fitoterapia

    pub_type: 杂志文章

    doi:10.1016/j.fitote.2012.01.002

    authors: Hussain J,Ur Rehman N,Hussain H,Al-Harrasi A,Ali L,Rizvi TS,Ahmad M,Mehjabeen

    更新日期:2012-04-01 00:00:00