Abstract:
:Two new atranones T and U (1 and 2), and three known analogues atranone B (3), atranone Q (4), and stachatranone C (5) were isolated from the toxigenic fungus Stachybotrys chartarum. Their structures and absolute configurations were elucidated by spectroscopic data and calculated ECD analyses. The cytotoxicities of all the atranones (1-5) were evaluated against MG-63 human osteosarcoma cell lines. Compound 4 exhibited significant cytotoxic effect against MG-63 with IC50 value of 8.6 μM, being more active than the positive control, 5-FU (IC50 10.4 μM). Morphological features of apoptosis activities were evaluated in 4-treated MG-63 cells. Compound 4 effectively induced apoptosis of MG-63, which was associated with G0/G1-phase cell cycle arrest. Flow cytometric analysis showed that the treatment by 4 significantly induced MG-63 cell apoptosis in a dose-dependent manner.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Qin YD,Fang FM,Zhou JJ,Wang RB,Xu SX,Li LH,Zhang HLdoi
10.1016/j.fitote.2020.104727subject
Has Abstractpub_date
2020-10-01 00:00:00pages
104727eissn
0367-326Xissn
1873-6971pii
S0367-326X(20)30309-9journal_volume
146pub_type
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