New polyketides, paralactonic acids A-E produced by Paraconiothyrium sp. SW-B-1, an endophytic fungus associated with a seaweed, Chondrus ocellatus Holmes.

Abstract:

:Five polyketides, paralactonic acids A-E (1-5) were isolated from Paraconiothyrium sp. SW-B-1, an endophytic fungus isolated from the seaweed, Chondrus ocellatus Holmes. Their structures were determined by various spectroscopic methods, predominantly by 2D NMR spectroscopic analyses. The absolute configurations of compounds 1-5 were determined by comparison of the experimental and calculated ECD spectra. Compound 5 showed moderate antibacterial activity and restored the growth of a mutant yeast strain inhibited by hyperactivated Ca2+-signaling.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Suzuki T,Ariefta NR,Koseki T,Furuno H,Kwon E,Momma H,Harneti D,Maharani R,Supratman U,Kimura KI,Shiono Y

doi

10.1016/j.fitote.2018.11.017

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

75-81

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(18)31029-3

journal_volume

132

pub_type

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