Abstract：
:Pocahemiketals A and B (1 and 2), two novel hemiketal sesquiterpenoids with unprecedented skeletons, were isolated from the essential oil of the aerial parts of Pogostemon cablin. In addition to a bicyclo[3.2.1]-carbon core, 1 and 2 possessed a hemiketal α,β-unsaturated-γ-lactone moiety. Their structures were determined by extensive spectroscopic analysis, electronic circular dichroism calculation, and single-crystal X-ray diffraction. Compound 2 exhibited significant vasorelaxant activity against phenylephrine-induced contraction of a rat aorta ring with the EC50 value of 16.32μM.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Zhu H,Zhou QM,Peng C,Chen MH,Li XN,Lin DS,Xiong Ldoi
10.1016/j.fitote.2017.05.013subject
Has Abstractpub_date
2017-07-01 00:00:00pages
67-71eissn
0367-326Xissn
1873-6971pii
S0367-326X(17)30642-1journal_volume
120pub_type
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