New cytotoxic diarylheptanoids from the rhizomes of Alpinia officinarum Hance.

abstract：:Two new triterpenoid estersaponins (1, 2) were isolated from the leaves of Pittosporum tobira 'Variegata' (Thunb.) W. T. Aiton, along with one known saponin (3) and one known flavonoid glycoside (4). Their structures were established by different spectroscopic methods including 1D and 2D NMR, UV, as well as ESI-MS ana...

journal_title：Fitoterapia

authors： El Dib RA,Eskander J,Mohamed MA,Mohammed NM

更新日期：2015-10-01 00:00:00

abstract：:A new phenylpropanoid glucoside and two new neolignans, namely (1S, 2R)-1-(3, 4, 5-trimethoxyphenyl)-3-(β-d-glucopyranosyloxy)-1, 2, 3-propanetriol (1), and (7R, 8R)-4, 7, 9, 9'-tetrahydroxy-3, 5, 3', 5'-tetramethoxy-8-4'-oxyneolignan 4-O-β-d-glucopyranoside (2) and 3', 9, 9'-trihydroxy-3, 5-dimethoxy-8-O-4'-neolignan...

journal_title：Fitoterapia

authors： Shu J,Liang F,Liang J,Liang Y,Li F,Shao F,Liu R,Huang H

更新日期：2015-07-01 00:00:00

abstract：:An endophytic fungal strain named Trichoderma atroviride was isolated from the bulb of Lycoris radiata. Following cultivation on rice medium, a novel 3-amino-5-hydroxy-5-vinyl-2-cyclopenten-1-one dimer, atrichodermone A (1), a new cyclopentenone derivative, atrichodermone B (2), and a new sesquiterpene, atrichodermone...

journal_title：Fitoterapia

authors： Zhou P,Wu Z,Tan D,Yang J,Zhou Q,Zeng F,Zhang M,Bie Q,Chen C,Xue Y,Luo Z,Wang J,Zhu H,Zhang Y

更新日期：2017-11-01 00:00:00

abstract：:Oil production from the seeds of Camellia oleifera Abel. causes a great waste of shells which contain a lot of bioactive components. The aim of this research was to isolate flavonoid from the shells of C. oleifera Abel. and evaluate its uses. The shells were extracted by 70% methanol, hydrolyzed by 2M hydrochloric aci...

journal_title：Fitoterapia

authors： Ye Y,Guo Y,Luo YT,Wang YF

更新日期：2012-12-01 00:00:00

abstract：:In our ongoing efforts of finding natural fungicides to fight food and feed spoilage during production and storage, the antifungal potential of Ghanaian Uvaria chamae P. Beauv. was investigated, with emphasis on plant metabolites targeting the fungal plasma membrane (PM) H(+)-ATPase. Ethyl acetate extract of U. chamae...

journal_title：Fitoterapia

authors： Kongstad KT,Wubshet SG,Kjellerup L,Winther AM,Staerk D

更新日期：2015-09-01 00:00:00

abstract：:As part of our search for biologically active anti-osteoporotic agents that enhance the differentiation and mineralization of osteoblastic MC3T3-E1 cells, we identified the ginsenoside Rd as the most active compound among ginsenosides. In this study, we showed that Rd stimulates osteoblastic differentiation and minera...

journal_title：Fitoterapia

authors： Kim DY,Park YG,Quan HY,Kim SJ,Jung MS,Chung SH

更新日期：2012-01-01 00:00:00

abstract：:A new cyclopeptide, pulvpeptin A (1), two pairs of norlignan lignanosides, tamariscinosides G and H (2, 3), together with five known compounds (4-8) were isolated from Selaginella pulvinata. The structures were elucidated by spectroscopic data and chemical degradation. The activity of tamariscinoside G (2) was evaluat...

journal_title：Fitoterapia

authors： Lv H,Li Y,Zhu M,Luo M,Qi J,Yu Z,Zhang H,Guo Y,Tong S,Li H,Yan J

更新日期：2020-06-01 00:00:00

abstract：:Chemical investigation of the liquid culture of the endophytic fungus Bipolaris sorokiniana A606, which was isolated from the medicinal plant Pogostemon cablin resulted in the isolation of four new cytotoxic compounds, named isocochlioquinones D-E (1-2) and cochlioquinones G-H (3-4), along with five known cochlioquino...

journal_title：Fitoterapia

authors： Wang M,Sun ZH,Chen YC,Liu HX,Li HH,Tan GH,Li SN,Guo XL,Zhang WM

更新日期：2016-04-01 00:00:00

abstract：:The plants of genus Toona are well known for diverse limonoid secondary metabolites, while polyacetylenes are rarely found from Toona species. In this work, six new polyacetylenes toonasindiynes A-F (1-6) and six known analogues (7-12) were isolated from the root bark of Toona sinensis. Their structures and absolute c...

journal_title：Fitoterapia

authors： Xu WJ,Li JH,Zhou MM,Luo J,Jian KL,Tian XM,Xia YZ,Yang L,Luo J,Kong LY

更新日期：2020-10-01 00:00:00

abstract：:The pharmacological active genus Thymus L. comprises over 200 species. Besides its traditional pharmacological use, thyme may reduce the risk of caries disease, however, there is very little respective literature. The pharmacological effects can be attributed to the secondary plant metabolites. The composition of the ...

journal_title：Fitoterapia

authors： Schött G,Liesegang S,Gaunitz F,Gleß A,Basche S,Hannig C,Speer K

更新日期：2017-09-01 00:00:00

abstract：:The isolation of jusmicranthin (1), a novel lignan from Justicia neesii, is reported. Compound 1 represents a new class of angularly fused arylnaphthalides having a gamma-hydroxylactone unit. ...

journal_title：Fitoterapia

authors： Rajasekhar D,Subbaraju GV

更新日期：2000-09-01 00:00:00

abstract：:Solanum nigrum L. (also called as European black nightshade) has been traditionally used as folk medicine and food in some regions. Phytochemical investigations of the immature fruits of S. nigrum yielded five steroidal alkaloid glycosides (1-5), including an unprecedented nor-spirosolane type steroidal alkaloid with ...

journal_title：Fitoterapia

authors： Xiang L,Wang Y,Yi X,He X

更新日期：2019-09-01 00:00:00

abstract：:The methanolic extract of the Zanthoxylum rhetsa Roxb. stem bark, given by oral route to mice at doses of 250 and 500 mg/kg, significantly reduced the abdominal contraction induced by acetic acid and the diarrhoeal episodes induced by castor oil in mice. ...

journal_title：Fitoterapia

authors： Rahman MT,Alimuzzaman M,Ahmad S,Chowdhury AA

更新日期：2002-07-01 00:00:00

abstract：:The root of Coptis chinensis Franch. (COCH) is regularly used for medicinal purposes, and has been prescribed alone or in combination with other traditional herbs for the treatment of diabetes. To investigate the effects of COCH on glucose utilization by skeletal muscles, we prepared an ethanol extract of COCH root (C...

journal_title：Fitoterapia

authors： Yang TC,Chao HF,Shi LS,Chang TC,Lin HC,Chang WL

更新日期：2014-03-01 00:00:00

abstract：:Four new sesquiterpenoids, phellinignins A-D (1-4), together with four known ones (5-8), were isolated from cultures of the fungus Phellinus igniarius. The structures were established by extensive spectroscopic methods including MS, NMR, and the single crystal X-ray diffraction. Compounds 1-3 and 5-8 are tremulane ses...

journal_title：Fitoterapia

authors： Wu PF,Ding R,Tan R,Liu J,Hu EM,Li CY,Liang GY,Yi P

更新日期：2020-01-01 00:00:00

abstract：:Phytochemical investigation on the stem bark of Toona sinensis was carried out by various chromatographic techniques resulting in the isolation and elucidation of two novel tirucallane triterpenoids, named (20S)-3-oxo-tirucalla-25-nor-7-en-24-oic acid (1) and (20S)-5α,8α-epidioxy-3-oxo-24-nor-6.9(11)-dien-23-oic acid ...

journal_title：Fitoterapia

authors： Tang J,Xu J,Zhang J,Liu WY,Xie N,Chen L,Feng F,Qu W

更新日期：2016-07-01 00:00:00

abstract：:Phytochemical investigations on Physalis. alkekengi L. var. franchetii, a widespread traditional Chinese medicine, led to the isolation and identification of three new sesquiterpenoids physalisitins A-C (1-3). Their structures were elucidated by NMR and HRESIMS analysis, and their absolute configurations were determin...

journal_title：Fitoterapia

authors： Zhang JL,Zhou FF,Li YZ,Feng T,Jiang LL,Jiang RW,Zhang XX,Li XD

更新日期：2020-03-01 00:00:00

abstract：:Investigation of the fruits of Khaya senegalensis resulted in the isolation of three new mexicanolide limonoids containing a rare conjugated diene lactone system named seneganolide A (1), 2-hydroxyseneganolide A (2) and 2-acetoxyseneganolide A (3). Two known limonoids, 3-deacetyl-7-deacetoxy-7-oxokhivorin (4) and meth...

journal_title：Fitoterapia

authors： Abdelgaleil SA,Iwagawa T,Doe M,Nakatani M

更新日期：2004-09-01 00:00:00

abstract：:The crude methanolic extracts of Hygrophila scricta and Peperomia pellucida were fractionated into petrol, dichloromethane, ethyl acetate and butanol. All the crude extracts and the fractions exhibited a very good level of broad spectrum antibacterial activity. The fractions were more active than the crude extracts. T...

journal_title：Fitoterapia

authors： Khan MR,Omoloso AD

更新日期：2002-06-01 00:00:00

abstract：:The isolation of a new flavan, 5,7,4'-trihydroxy-8-ethoxycarbonylflavan (1), from the root of Daphne odora var. atrocaulis is reported. ...

journal_title：Fitoterapia

authors： Zhang W,Zhang W,Li T,Liu R,Li H,Chen H

更新日期：2004-12-01 00:00:00

abstract：:Two new epimeric isopavine N-oxides, amuresinine N-oxide A (1) and B (2), were isolated from Meconopsis horridula var. racemosa. Their structures were elucidated by spectroscopic methods. ...

journal_title：Fitoterapia

authors： Xie H,Xu J,Teng R,Li B,Wang D,Yang C

更新日期：2001-02-01 00:00:00

abstract：:Smyrnium olusatrum (Apiaceae), well known as wild celery, is a biennal celery-scented plant used for many centuries as a vegetable, then abandoned after the introduction of celery. In the present work, the essential oil obtained from inflorescences and the amounts of its main constituents isofuranodiene, curzerene and...

journal_title：Fitoterapia

authors： Quassinti L,Maggi F,Barboni L,Ricciutelli M,Cortese M,Papa F,Garulli C,Kalogris C,Vittori S,Bramucci M

更新日期：2014-09-01 00:00:00

abstract：:Aloe barbadensis Mill has been used as food and medicine for a long time. In order to investigate the chemical constituents of A. barbadensis and their inhibitory activities towards phosphodiesterase-4D (PDE4D), 70% methanol extract of the dried A. barbadensis powder was employed. Phytochemical investigation has led t...

journal_title：Fitoterapia

authors： Zhong J,Huang Y,Ding W,Wu X,Wan J,Luo H

更新日期：2013-12-01 00:00:00

abstract：:A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to identify and quantify the camptothecin quaternary derivative CPT8 for application in pharmacokinetics and tissue distribution studies. Rat plasma and tissue samples were extracted with methanol by using camptothecin as the internal sta...

journal_title：Fitoterapia

authors： Li Q,Zhu Q,Zhang X,Hua C,Deng X,Zhao T,Sun B

更新日期：2013-10-01 00:00:00

abstract：:The ecological role of maytansine, an important antineoplastic and antimicrobial compound with high cytotoxicity, particularly as a chemical defense compound has remained elusive since its discovery in the 1970s in Maytenus and Putterlickia plants. In the present study, we have used MALDI-imaging-HRMS to visualize the...

journal_title：Fitoterapia

authors： Eckelmann D,Kusari S,Spiteller M

更新日期：2017-06-01 00:00:00

abstract：:A new altersolanol derivative, 4-dehydroxyaltersolanol A (9), along with two known sesquiterpenoids, (S)-7'-hydroxyabscisic acid (7) and (S)-abscisic acid (8) were obtained from the endophytic fungus, Nigrospora oryzae, isolated from leaves of Combretum dolichopetalum. The host plant yielded six known compounds includ...

journal_title：Fitoterapia

authors： Uzor PF,Ebrahim W,Osadebe PO,Nwodo JN,Okoye FB,Müller WE,Lin W,Liu Z,Proksch P

更新日期：2015-09-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is highly prevalent among global populations, with an estimated number of infected patients being 170 million. Approximately 70-80% of patients acutely infected with HCV will progress to chronic liver disease, such as liver cirrhosis and hepatocellular carcinoma, which is a substantia...

journal_title：Fitoterapia

authors： Wahyuni TS,Widyawaruyanti A,Lusida MI,Fuad A,Soetjipto,Fuchino H,Kawahara N,Hayashi Y,Aoki C,Hotta H

更新日期：2014-12-01 00:00:00

abstract：:Four new lathyrane-type diterpenoids (1-4) and a novel macrocyclic diterpenoid (5) featuring a 5/7/7/4-fused ring system, together with seventeen known ones (6-22), were isolated from the seeds of Euphorbia lathyris. Their structures were elucidated by extensive spectroscopic analyses and single crystal X-ray crystall...

journal_title：Fitoterapia

authors： Zuo Q,Mu HY,Gong Q,Ding X,Wang W,Zhang HY,Zhao WM

更新日期：2021-01-26 00:00:00

abstract：:Infusions of Picrolemma sprucei roots, stems and leaves are used in traditional medicine throughout the Amazon region from the Guianas to Brazil and Peru in the treatment of gastritis, intestinal helminths and malaria. As there are no studies describing its mode of action in providing a gastroprotective effect, we det...

journal_title：Fitoterapia

authors： Vieira SM,Silva RL,Lemos HP,Amorim RC,Silva EC,Reinach PS,Cunha FQ,Pohlit AM,Cunha TM

更新日期：2014-06-01 00:00:00

abstract：:The fruits of Piper tuberculatum Jacq yielded piperine S (1) and N-(12,13,14-trimethoxydihydrocinnamoyl)-delta(3)-piperidin-2-one (2). Their complete NMR analysis based on one- and two-dimensional experiments is reported. ...

journal_title：Fitoterapia

authors： de O Chaves MC,de F Júnior AG,de O Santos BV

更新日期：2003-02-01 00:00:00