Glomerxanthones A-C, three xanthonolignoid C-glycosides from Polygala glomerata Lour.

abstract：:One new resveratrol analogue, 1-(3',4',5'-trimethoxyphenyl)-2-methoxy-2-(4″-methoxyphenyl)-ethane-1-ol (1), and two new prenylisoflavones, 4'-hydroxy-5,7-dimethoxy-6-(3-methyl-2-butenyl)-isoflavone (2), and derrubon 5-methyl ether (3), together with 17 known compounds including one new natural product, 5,7-dihydroxy-3...

journal_title：Fitoterapia

authors： Zhang HX,Lunga PK,Li ZJ,Dai Q,Du ZZ

更新日期：2014-06-01 00:00:00

abstract：:Two new ent-kaurene diterpenoids, 15α-acetoxyl-6,11α-epoxy-6α-hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7-olide (1), 15α-hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide (2), together with ten known compounds (5-14) were isolated from the leaves of Isodon rubescens. Their structures were elucidated mainly by ...

journal_title：Fitoterapia

authors： Xie RJ,Yan FL,Hai GF,Hou RJ,Ding MM,Bai YX

更新日期：2011-06-01 00:00:00

abstract：:Pocahemiketals A and B (1 and 2), two novel hemiketal sesquiterpenoids with unprecedented skeletons, were isolated from the essential oil of the aerial parts of Pogostemon cablin. In addition to a bicyclo[3.2.1]-carbon core, 1 and 2 possessed a hemiketal α,β-unsaturated-γ-lactone moiety. Their structures were determin...

journal_title：Fitoterapia

authors： Zhu H,Zhou QM,Peng C,Chen MH,Li XN,Lin DS,Xiong L

更新日期：2017-07-01 00:00:00

abstract：:Activity-guided fractionation of the methanol extract of Vitis vinifera bark led to the isolation of epsilon-viniferin, ampelopcin A, vitisin A and vitisin B. Vitisin A and vitisin B showed a remarkable inhibitory activity against 3-hydroxy-3-methylglutaryl-Coenzyme A (HMG-CoA) reductase with IC50 value of 42.1 microM...

journal_title：Fitoterapia

authors： Koo M,Kim SH,Lee N,Yoo MY,Ryu SY,Kwon DY,Kim YS

更新日期：2008-04-01 00:00:00

abstract：:Chemical examination of the ethanol extract of rhizomes of Iris tectorum led to the isolation and characterization of three new lignans, (7R,7'R,8S,8'S)-5'-methoxy-neo-olivil (1a), (7S,7'S,8R,8'R) -5'-methoxy-neo-olivil (1b), (7S,7'R,8S,8'S)-neo-olivil (2a), (7R,7'S,8R,8'R)-neo-olivil (2b), (7R,7'R,8S,8'S,7''S,8''S)-t...

journal_title：Fitoterapia

authors： Zhang CL,Wang Y,Liu YF,Liang D,Hao ZY,Luo H,Chen RY,Yu DQ

更新日期：2016-01-01 00:00:00

abstract：:The isolation of cinchonicine-derived alkaloids epicinchonicinol (1), cinchonidicinol (2) and a mixture of dihydrocinchonicinol and dihydrocinchonidicinol (3) from the dried bark of Ladenbergia oblongifolia, is reported along with (1)H and (13)C-NMR data. ...

journal_title：Fitoterapia

authors： Okunade AL,Lewis WH,Elvin-Lewis MP,Casper SJ,Goldberg DE

更新日期：2001-08-01 00:00:00

abstract：:Isothiocyanates (ITCs), the breakdown products of glucosinolates found primarily in species of Brassicaceae (Cruciferae), are potential anti-cancer compounds. This review compiles data on how through different modes of action ITCs and their synthetic counterparts target leukemia. ...

journal_title：Fitoterapia

authors： Prashar A,Siddiqui F,Singh AK

更新日期：2012-03-01 00:00:00

abstract：:The plant derived camptothecin (CPT) is a pentacyclic pyrroloquinoline alkaloid with unique antitumor activity. Successive discoveries of new CPT-producing plants occurred in recent years due to market demands. The scattered distribution among angiosperms drew researchers' attention. The aim of this review is to appra...

journal_title：Fitoterapia

authors： Pu X,Zhang CR,Zhu L,Li QL,Huang QM,Zhang L,Luo YG

更新日期：2019-04-01 00:00:00

abstract：:Five novel globoscinic acid derivatives, aspergilates A-E (1-5) have been isolated from endophytic fungus Aspergillus sp. derived from Paeonia ostii. The structures of aspergilates A-E were determined by in-depth analyses of NMR spectra, HRESIMS and CD experiments. The absolute configurations of compounds 2-5 were det...

journal_title：Fitoterapia

authors： Wang JT,Zhang PL,Liu JS,Wang GK,Xu FQ,Chen L,Yu Y,Wang G

更新日期：2018-11-01 00:00:00

abstract：:Three new mixed terpenoids, tricycloalternarenes (TCAs) F-H (1-3), together with ten known tricycloalternarenes (4-13), were isolated from the Czapek's culture of an endophytic fungus Ulocladium sp. Their structures were identified by extensive spectroscopic experiments (NMR and MS) and comparison with literature data...

journal_title：Fitoterapia

authors： Wang QX,Bao L,Yang XL,Guo H,Ren B,Guo LD,Song FH,Wang WZ,Liu HW,Zhang LX

更新日期：2013-03-01 00:00:00

abstract：:The effect of Cyclovirobuxine D, an active ingredient from Buxus microphylla, was investigated in the potential prevention of cardiac dysfunction in rats with congestive heart failure. Heart failure was induced by left coronary artery occlusion and verified using echocardiography. Cyclovirobuxine D was administered fo...

journal_title：Fitoterapia

authors： Yu B,Fang TH,Lü GH,Xu HQ,Lu JF

更新日期：2011-09-01 00:00:00

abstract：:Three new caged polyprenylated benzophenone derivatives named burlemarxiones D-F (1-3) were isolated from the hexane extract of Clusia burle-marxii trunks. Burlemarxione D (1) contains the tetracyclo[8.3.1.03,11.05,10]tetradecane core skeleton also observed for burlemarxione A, its probable immediate precursor. Howeve...

journal_title：Fitoterapia

authors： Ferraz CG,Ribeiro PR,Mendonça R,Silveira ER,Cruz FG

更新日期：2020-10-16 00:00:00

abstract：:A simple, sensitive and accurate liquid chromatographic method with photodiode-array detection was developed for determination of dehydroevodiamine with detection wavelength at 368 nm and column temperature at 30 degrees C. The separation was carried out on an Agilent Zorbax SB-C(18) column (250 mm x 4.6 mm, 5 microm)...

journal_title：Fitoterapia

authors： Zhao Y,Zhou X,Chen HG,Gong XJ,Cai ZW,Zhou CY

更新日期：2009-10-01 00:00:00

abstract：:Two spiro paclitaxel-mimics consisting only of an oxetane D-ring and a C-13 side chain were designed and synthesized on the basis of analysis of structure-activity relationships (SAR) of paclitaxel. In vitro microtubule-stabilizing and antiproliferative assays indicated a moderate weaker activity of the mimics than pa...

journal_title：Fitoterapia

authors： Chen XX,Gao F,Wang Q,Huang X,Wang D

更新日期：2014-01-01 00:00:00

abstract：:The methanol extracts of Clematis papuasica leaves and stem bark and of Nauclea obversifolia leaves, stem and root barks showed awide spectrum of antibacterial activity which was increased on fractionation (petrol, dichloromethane, ethyl acetate), the ethyl acetate fractions being in all cases the most effective. None...

journal_title：Fitoterapia

authors： Khan MR,Kihara M,Omoloso AD

更新日期：2001-06-01 00:00:00

abstract：:Four new eburnamine-aspidospermine type bisindole alkaloids, namely, mekongenines C-F (1-4), along with 27 known indole alkaloids were isolated from the twigs and leaves of Bousigonia mekongensis. Their structures with the absolute configurations were elucidated by spectroscopic methods and ECD analyses. All new compo...

journal_title：Fitoterapia

authors： Fu YH,Li SL,Li SF,He HP,Di YT,Zhang Y,Hao XJ

更新日期：2014-10-01 00:00:00

abstract：:The Src-homology 2 domain-containing phosphatase 2 (SHP2), encoded by PTPN11, has been reported oncogenic tyrosine phosphatase associated with various tumors and played critical roles in many cell signaling events. Targeting SHP2 by small molecules may be a promising way for cancer therapy. Herein, a new abietane dite...

journal_title：Fitoterapia

authors： Liu DM,Cao ZX,Yan HL,Li W,Yang F,Zhao WJ,Diao QC,Tan YZ

更新日期：2020-03-01 00:00:00

abstract：:Tunicyclin L (1), cyclo (L-Pro1-Gly-L-Phe1-L-Ile-L-Pro2-L-Phe2 -L-Thr-L-Val), and 11 known compounds, including one cyclic peptide (2), eight carboline alkaloids (3 -10), one lignan (11) and one flavone (12) were isolated from the roots of Psammosilene tunicoides. Their structures were elucidated on the basis of exten...

journal_title：Fitoterapia

authors： Hou Y,Wang M,Sun C,Peng C,Zhang Y,Li X

更新日期：2020-09-01 00:00:00

abstract：:Usually isolated from Garcinia (Clusiaceae) or Hypericum (Hypericaceae) species, some Polycyclic Polyprenylated AcylPhloroglucinols (PPAPs) have been recently reported as potential research tools for immunotherapy. Aiming at exploring the chemodiversity of PPAPs amongst Garcinia genus, a dereplication process suitable...

journal_title：Fitoterapia

authors： Bruguière A,Derbré S,Coste C,Le Bot M,Siegler B,Leong ST,Sulaiman SN,Awang K,Richomme P

更新日期：2018-11-01 00:00:00

abstract：:The effects of the essential oil of Eucalyptus tereticornis (EOET), especially the effects of its constituents alpha- and beta-pinene, were studied on rat trachea in vitro. In tracheal rings, EOET, alpha- or beta-pinene potentiated the contractions induced by acetylcholine (ACh). Contractions induced by K(+) (60mM) we...

journal_title：Fitoterapia

authors： Lima FJ,Brito TS,Freire WB,Costa RC,Linhares MI,Sousa FC,Lahlou S,Leal-Cardoso JH,Santos AA,Magalhães PJ

更新日期：2010-09-01 00:00:00

abstract：:A pair of diastereoisomers, the N-glycosylated derivatives of dioxindole-3-hydroxy-3-acetic acid 1-2, and their conjugates with flavonoids 3-8, was isolated from the seeds of Ziziphus jujuba var. spinosa. Their structures were elucidated by NMR spectroscopic analyses, and the absolute configurations were determined by...

journal_title：Fitoterapia

authors： Li M,Wang Y,Tsoi B,Jin XJ,He RR,Yao XJ,Dai Y,Kurihara H,Yao XS

更新日期：2014-12-01 00:00:00

abstract：:Thuja occidentalis L. is indigenous for Northern America and commonly cultivated in Europe. Raw materials obtained from this tree are widely applied in the ethnomedicine and phytotherapy of numerous ailments, incl. scurvy, cystitis, rheumatism and cancer. Despite wide medicinal applications of Thuja occidentalis, stil...

journal_title：Fitoterapia

authors： Pudełek M,Catapano J,Kochanowski P,Mrowiec K,Janik-Olchawa N,Czyż J,Ryszawy D

更新日期：2019-04-01 00:00:00

abstract：:Aconitum carmichaelii has been used in traditional Chinese medicine for treating various diseases for several thousand years. Based on the biosynthetic pathway of some alkaloids such as C19-diterpenoid alkaloids and obvious differences in alkaloid content between leaves of two A. carmichaelii varieties has been report...

journal_title：Fitoterapia

authors： Yang Y,Hu P,Zhou X,Wu P,Si X,Lu B,Zhu Y,Xia Y

更新日期：2020-01-01 00:00:00

abstract：:A screening was conducted with 26 plants collected in the Brazilian southeast region, to identify plant extracts with antibacterial properties against Aeromonas hydrophila, Bacillus subtilis, Pseudomonas aeruginosa and Staphylococcus aureus. Initially, the agar diffusion method was employed. Then, those extracts prese...

journal_title：Fitoterapia

authors： Oliveira DF,Pereira AC,Figueiredo HC,Carvalho DA,Silva G,Nunes AS,Alves DS,Carvalho HW

更新日期：2007-02-01 00:00:00

abstract：:The tea seed triterpene saponin (TS) from Camellia sinensis was found to exhibit better antitumor activity in vivo in S180 implanted ICR mice and QR inducing activity for hepa lclc7 cells respectively compared with the total tea seed saponin (TTS), hydrolysate of the TTS and tea seed flavonoid glycosides (TF). By bioa...

journal_title：Fitoterapia

authors： Li N,Ma ZJ,Chu Y,Wang Y,Li X

更新日期：2013-01-01 00:00:00

abstract：:The effect of berberine hydrochloride (BBR) on inducible cyclooxygenase-2 (COX-2) in small intestinal mucosa and related mechanisms was investigated in a rat model of acute endotoxemia. The results showed that lipopolysaccharide (LPS) increased COX-2 expression, whereas SB202190 and BBR curtailed it. LPS increased pho...

journal_title：Fitoterapia

authors： Feng AW,Yu C,Mao Q,Li N,Li QR,Li JS

更新日期：2011-10-01 00:00:00

abstract：:Smyrnium olusatrum (Apiaceae), well known as wild celery, is a biennal celery-scented plant used for many centuries as a vegetable, then abandoned after the introduction of celery. In the present work, the essential oil obtained from inflorescences and the amounts of its main constituents isofuranodiene, curzerene and...

journal_title：Fitoterapia

authors： Quassinti L,Maggi F,Barboni L,Ricciutelli M,Cortese M,Papa F,Garulli C,Kalogris C,Vittori S,Bramucci M

更新日期：2014-09-01 00:00:00

abstract：:Sardinian wild Euphorbia pithyusa, E. semiperfoliata, E. dendroides and E. characias seed oils were analyzed for their fatty acids, unsaponifiable and tocopherol content. Total tocopherol content showed a wide variability, ranging from 939 mg/kg in E. semiperfoliata seeds to its absence in E. characias. The results on...

journal_title：Fitoterapia

authors： Bruni R,Muzzoli M,Ballero M,Loi MC,Fantin G,Poli F,Sacchetti G

更新日期：2004-01-01 00:00:00

abstract：:The antimicrobial activity of ethanol, acetone and aqueous extracts of the aerial parts of Pseudognaphalium moritzianum was evaluated. Ethanol and acetone extracts showed activity against Staphlococcus aureus, Enterococcus faecalis and Pseudomonas aeruginosa. The aqueous extract was active against S. aureus and P. aer...

journal_title：Fitoterapia

authors： Rangel D,Garcia I,Velasco J,Buitrago D,Velazco E

更新日期：2002-12-01 00:00:00

abstract：:A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to identify and quantify the camptothecin quaternary derivative CPT8 for application in pharmacokinetics and tissue distribution studies. Rat plasma and tissue samples were extracted with methanol by using camptothecin as the internal sta...

journal_title：Fitoterapia

authors： Li Q,Zhu Q,Zhang X,Hua C,Deng X,Zhao T,Sun B

更新日期：2013-10-01 00:00:00