Aspergilates A to E, second metabolites from Aspergillus sp. isolated from Paeonia ostii.

Abstract:

:Five novel globoscinic acid derivatives, aspergilates A-E (1-5) have been isolated from endophytic fungus Aspergillus sp. derived from Paeonia ostii. The structures of aspergilates A-E were determined by in-depth analyses of NMR spectra, HRESIMS and CD experiments. The absolute configurations of compounds 2-5 were determined by the ECD calculations based on quantum chemistry. Cytotoxic activities against five selected tested tumor cell lines of 1-5 were evaluated.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Wang JT,Zhang PL,Liu JS,Wang GK,Xu FQ,Chen L,Yu Y,Wang G

doi

10.1016/j.fitote.2018.10.027

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

204-208

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(18)31680-0

journal_volume

131

pub_type

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