Two novel eremophylane acetophenone conjugates from Colletotrichum gloeosporioides, an endophytic fungus in Salvia miltiorrhiza.

Abstract:

:Two novel eremophylane acetophenone conjugates, colletotricholides A (1) and B (2), were isolated from the solid fermentation cultures of an endophytic fungus Colletotrichum gloeosporioides XL1200 isolated from the aerial parts of Salvia miltiorrhiza. The chemical structures of 1-2 were characterized by extensive spectroscopic methods and single-crystal X-ray crystallography. Structurally, compounds 1-2 are two unusual eremophylane acetophenone conjugates originating from the hybrid pathways of polyketide synthase and sesquiterpene synthase. In addition, compounds 1-2 were inactive against tested pathogens.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Zhao WT,Liu QP,Chen HY,Zhao W,Gao Y,Yang XL

doi

10.1016/j.fitote.2020.104474

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

104474

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(19)32464-5

journal_volume

141

pub_type

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