Naphthofuranone derivatives and other constituents from Pachira aquatica with inhibitory activity on superoxide anion generation by neutrophils.

Abstract:

:Two new naphthofuranone derivatives, 11-hydroxy-2-O-methylhibiscolactone A (1) and O-methylhibiscone D (2), have been isolated from the stems of Pachira aquatica, together with 18 known compounds (3-20). The structures of two new compounds were determined through spectroscopic and MS analyses. Among the isolated compounds, 11-hydroxy-2-O-methylhibiscolactone A (1), isohemigossylic acid lactone-7-methyl ether (4), gmelofuran (6), and 5-hydroxyauranetin (8) exhibited inhibition (IC50≤28.84μM) of superoxide anion generation by human neutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP).

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Cheng LY,Liao HR,Chen LC,Wang SW,Kuo YH,Chung MI,Chen JJ

doi

10.1016/j.fitote.2016.12.008

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

16-21

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(16)30560-3

journal_volume

117

pub_type

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