Gossypol inhibits 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase: Its possible use for the treatment of prostate cancer.

abstract：:A new sesquiterpene coumarin with a novel sesquiterpene carbon framework, Sinkiangenorin D, and ten known sesquiterpene coumarins were isolated from the seeds of Ferula sinkiangensis. The structures of these compounds, including the relative stereochemistry, were elucidated on the basis of spectroscopic data. All of t...

journal_title：Fitoterapia

authors： Li G,Li X,Cao L,Zhang L,Shen L,Zhu J,Wang J,Si J

更新日期：2015-06-01 00:00:00

abstract：:Ten new tricyclic prezizaane types sesquiterpenoids (1-10) were isolated from ethyl ether extract of agarwood originated from Aquilaria sp. Their structures were unambiguously elucidated on the basis of 1D and 2D NMR spectra as well as by HRESIMS data. The absolute configuration of the new prezizaenes 1, 2 and 4 was d...

journal_title：Fitoterapia

authors： Yang YL,Li W,Wang H,Yang L,Yuan JZ,Cai CH,Chen HQ,Dong WH,Ding XP,Jiang B,Mándi A,Kurtán T,Mei WL,Dai HF

更新日期：2019-10-01 00:00:00

abstract：:Beyond its role in the activation of protein C, the endothelial cell protein C receptor (EPCR) plays an important role in the cytoprotective pathway. EPCR can be shed from the cell surface, which is mediated by tumor necrosis factor-α converting enzyme (TACE). Polyozellin, a major constituent of a Korea edible mushroo...

journal_title：Fitoterapia

authors： Lee W,Yang EJ,Park DH,Bae JS

更新日期：2016-01-01 00:00:00

abstract：:Three undescribed polycyclic polyprenylated acylphloroglucinols (PPAPs) and three tocotrienols derivatives, named as paucinochymol A-F (1-3 and 10-12), together with six known PPAPs, were isolated from the fruits of Garcinia paucinervis. Their structures and absolute configurations were determined by extensive NMR ana...

journal_title：Fitoterapia

authors： Tan X,Zhong F,Teng H,Li Q,Li Y,Mei Z,Chen Y,Yang G

更新日期：2020-10-01 00:00:00

abstract：:Eight new dihydrobenzofuran neolignans, pinnatifidanin C I-VIII (1-8), together with two known analogs (9-10) were isolated from the seeds of Crataegus pinnatifida. Their structures were elucidated by spectroscopic analyses, especially 1D, 2D NMR and CD spectra. The cytotoxic activities of all isolates against human c...

journal_title：Fitoterapia

authors： Huang XX,Zhou CC,Li LZ,Peng Y,Lou LL,Liu S,Li DM,Ikejima T,Song SJ

更新日期：2013-12-01 00:00:00

abstract：:One new resveratrol analogue, 1-(3',4',5'-trimethoxyphenyl)-2-methoxy-2-(4″-methoxyphenyl)-ethane-1-ol (1), and two new prenylisoflavones, 4'-hydroxy-5,7-dimethoxy-6-(3-methyl-2-butenyl)-isoflavone (2), and derrubon 5-methyl ether (3), together with 17 known compounds including one new natural product, 5,7-dihydroxy-3...

journal_title：Fitoterapia

authors： Zhang HX,Lunga PK,Li ZJ,Dai Q,Du ZZ

更新日期：2014-06-01 00:00:00

abstract：:Escin exerts potent glucocorticoid-like anti-inflammatory effects. The aim of this study was to investigate whether the anti-inflammatory effect of escin is through the up-regulation of glucocorticoids and if escin induces pathological changes in immune organs. Mice were administrated with escin intravenously for 7 da...

journal_title：Fitoterapia

authors： Zhang L,Wang H,Fan H,Wang T,Jiang N,Yu P,Fu F

更新日期：2011-09-01 00:00:00

abstract：:As part of our search for biologically active anti-osteoporotic agents that enhance the differentiation and mineralization of osteoblastic MC3T3-E1 cells, we identified the ginsenoside Rd as the most active compound among ginsenosides. In this study, we showed that Rd stimulates osteoblastic differentiation and minera...

journal_title：Fitoterapia

authors： Kim DY,Park YG,Quan HY,Kim SJ,Jung MS,Chung SH

更新日期：2012-01-01 00:00:00

abstract：:Goldenseal (Hydrastis canadensis) has emerged as one of the top five herbal supplements in the world-wide market. A convenient method for the determination of the quality and possible adulteration of goldenseal products is thin-layer chromatography (TLC). TLC analysis of 10 goldenseal samples using two solvent systems...

journal_title：Fitoterapia

authors： Govindan M,Govindan G

更新日期：2000-06-01 00:00:00

abstract：:The root of Coptis chinensis Franch. (COCH) is regularly used for medicinal purposes, and has been prescribed alone or in combination with other traditional herbs for the treatment of diabetes. To investigate the effects of COCH on glucose utilization by skeletal muscles, we prepared an ethanol extract of COCH root (C...

journal_title：Fitoterapia

authors： Yang TC,Chao HF,Shi LS,Chang TC,Lin HC,Chang WL

更新日期：2014-03-01 00:00:00

abstract：:Four new C18-diterpenoid alkaloids, weisaconitines A-D (1-4), were isolated from Aconitum weixiense. Based on extensive UV, IR, MS, 1D and 2D NMR analyses, their structures were elucidated as 8-O-ethyldolaconine (1), 4-demethylgenicunine B (2), 14-oxoaconosine (3), and 8-O-ethylaconosine (4). The analgesic activity of...

journal_title：Fitoterapia

authors： Zhao DK,Ai HL,Zi SH,Zhang LM,Yang SC,Guo HC,Shen Y,Chen YP,Chen JJ

更新日期：2013-12-01 00:00:00

abstract：:Panax ginseng is an indigenous medicinal herb and has traditionally been used among Asian population for relief of many human ailments. We investigated the prophylactic role of Korean P. ginseng extract (KG) against X-ray irradiation-induced emesis in an acute rat pica model. Rats were treated with KG (12.5, 25, 50 mg...

journal_title：Fitoterapia

authors： Balaji Raghavendran HR,Rekha S,Cho HK,Jang SS,Son CG

更新日期：2012-09-01 00:00:00

abstract：:The antioxidant effect of aqueous methanolic herb extracts of Serratula coronata, S. wolffii and S. tinctoria was investigated using both enzyme-dependent and enzyme-independent systems. The extracts displayed concentration-dependent inhibition of lipid peroxidation. Flavonoids and ecdysteroids present in the extracts...

journal_title：Fitoterapia

authors： Báthori M,Zupkó I,Hunyadi A,Gácsné-Baitz E,Dinya Z,Forgó P

更新日期：2004-03-01 00:00:00

abstract：:Oil production from the seeds of Camellia oleifera Abel. causes a great waste of shells which contain a lot of bioactive components. The aim of this research was to isolate flavonoid from the shells of C. oleifera Abel. and evaluate its uses. The shells were extracted by 70% methanol, hydrolyzed by 2M hydrochloric aci...

journal_title：Fitoterapia

authors： Ye Y,Guo Y,Luo YT,Wang YF

更新日期：2012-12-01 00:00:00

abstract：:Pocahemiketals A and B (1 and 2), two novel hemiketal sesquiterpenoids with unprecedented skeletons, were isolated from the essential oil of the aerial parts of Pogostemon cablin. In addition to a bicyclo[3.2.1]-carbon core, 1 and 2 possessed a hemiketal α,β-unsaturated-γ-lactone moiety. Their structures were determin...

journal_title：Fitoterapia

authors： Zhu H,Zhou QM,Peng C,Chen MH,Li XN,Lin DS,Xiong L

更新日期：2017-07-01 00:00:00

abstract：:This manuscript reports on the first CE-method suitable for analyzing twelve pharmacologically relevant compounds (flavonoids, caffeic acids and leontopodic acid) in the aerial parts of Leontopodium alpinum. By using a 60mM borax buffer containing 25mM SDS and 35% acetonitrile the analytes could be well resolved in 25...

journal_title：Fitoterapia

authors： Ganzera M,Greifeneder V,Schwaiger S,Stuppner H

更新日期：2012-12-01 00:00:00

abstract：:Two new alkaloids were isolated from the bark of Sarcomelicope megistophylla. Cyclomegistine B (1), a new quinolone alkaloid, that possesses a rare cyclobuta[b]quinoline ring system and sarcomejine B (2) which is a quinolone alkaloid with an unusual side chain. The structure of both compounds was elucidated on the bas...

journal_title：Fitoterapia

authors： Mitaku S,Fokialakis N,Magiatis P,Tillequin F

更新日期：2007-02-01 00:00:00

abstract：:Curcuminoids possess powerful antioxidant activity as demonstrated in many chemical in vitro tests and in several in vivo trials. Nevertheless, the mechanism of this activity is not completely elucidated and studies on the in vivo antioxidant effects are still needed. Metabolomics may be used as an attractive approach...

journal_title：Fitoterapia

authors： Dall'Acqua S,Stocchero M,Boschiero I,Schiavon M,Golob S,Uddin J,Voinovich D,Mammi S,Schievano E

更新日期：2016-03-01 00:00:00

abstract：:Chemical and biocatalytic synthesis of seven previously undescribed marchantin A ester derivatives has been presented. Chemical synthesis afforded three peresterified bisbibenzyl products (TE1-TE3), while enzymatic method, using lipase, produced regioselective monoester derivatives (ME1-ME4). The antiproliferative act...

journal_title：Fitoterapia

authors： Novakovic M,Simić S,Koračak L,Zlatović M,Ilic-Tomic T,Asakawa Y,Nikodinovic-Runic J,Opsenica I

更新日期：2020-04-01 00:00:00

abstract：:Cajaninstilbene acid (CSA), a bioactive constituent isolated from pigeon pea leaves, exhibited neuroprotective activities in previous studies. The present study aims to evaluate the antidepressant effects of CSA by using behavioral despair models of tail suspension test (TST) and forced swimming test (FST), and a chro...

journal_title：Fitoterapia

authors： Zhang MD,Tao X,Pan RL,Wang LS,Li CC,Zhou YF,Liao YH,Chen SG,Chang Q,Liu XM

更新日期：2020-03-01 00:00:00

abstract：:Smyrnium olusatrum (Apiaceae), well known as wild celery, is a biennal celery-scented plant used for many centuries as a vegetable, then abandoned after the introduction of celery. In the present work, the essential oil obtained from inflorescences and the amounts of its main constituents isofuranodiene, curzerene and...

journal_title：Fitoterapia

authors： Quassinti L,Maggi F,Barboni L,Ricciutelli M,Cortese M,Papa F,Garulli C,Kalogris C,Vittori S,Bramucci M

更新日期：2014-09-01 00:00:00

abstract：:Chemical investigation of the liquid culture of the endophytic fungus Bipolaris sorokiniana A606, which was isolated from the medicinal plant Pogostemon cablin resulted in the isolation of four new cytotoxic compounds, named isocochlioquinones D-E (1-2) and cochlioquinones G-H (3-4), along with five known cochlioquino...

journal_title：Fitoterapia

authors： Wang M,Sun ZH,Chen YC,Liu HX,Li HH,Tan GH,Li SN,Guo XL,Zhang WM

更新日期：2016-04-01 00:00:00

abstract：:Natural products chemistry is the discipline that lies at the heart of modern pharmacognosy. The field encompasses qualitative and quantitative analytical tools that range from spectroscopy and spectrometry to chromatography. Among other things, modern research on crude botanicals is engaged in the discovery of the ph...

journal_title：Fitoterapia

authors： Betz JM,Brown PN,Roman MC

更新日期：2011-01-01 00:00:00

abstract：:Three new mixed terpenoids, tricycloalternarenes (TCAs) F-H (1-3), together with ten known tricycloalternarenes (4-13), were isolated from the Czapek's culture of an endophytic fungus Ulocladium sp. Their structures were identified by extensive spectroscopic experiments (NMR and MS) and comparison with literature data...

journal_title：Fitoterapia

authors： Wang QX,Bao L,Yang XL,Guo H,Ren B,Guo LD,Song FH,Wang WZ,Liu HW,Zhang LX

更新日期：2013-03-01 00:00:00

abstract：:A new cyclopeptide, pulvpeptin A (1), two pairs of norlignan lignanosides, tamariscinosides G and H (2, 3), together with five known compounds (4-8) were isolated from Selaginella pulvinata. The structures were elucidated by spectroscopic data and chemical degradation. The activity of tamariscinoside G (2) was evaluat...

journal_title：Fitoterapia

authors： Lv H,Li Y,Zhu M,Luo M,Qi J,Yu Z,Zhang H,Guo Y,Tong S,Li H,Yan J

更新日期：2020-06-01 00:00:00

abstract：:The isolation of a new flavan, 5,7,4'-trihydroxy-8-ethoxycarbonylflavan (1), from the root of Daphne odora var. atrocaulis is reported. ...

journal_title：Fitoterapia

authors： Zhang W,Zhang W,Li T,Liu R,Li H,Chen H

更新日期：2004-12-01 00:00:00

abstract：:Three new xanthones, named kaennacowanols A-C (1-3), along with nineteen known xanthones were isolated from the roots of Garcinia cowa Roxb. Their structures were determined by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicity against KB and HeLa cell lines. Compounds 17 and 22 showe...

journal_title：Fitoterapia

authors： Kaennakam S,Siripong P,Tip-Pyang S

更新日期：2015-04-01 00:00:00

abstract：:Bioassay-guided fractionation of the dichloromethane extract of the fungus Neofusicoccum austral SYSU-SKS024 led to the isolation of three new ethylnaphthoquinone derivatives, neofusnaphthoquinone A (1), 6-(1-methoxylethy1)-2,7-dimethoxyjuglone (2), (3R,4R)-3-methoxyl-botryosphaerone D (6), together with six known ana...

journal_title：Fitoterapia

authors： Cui H,Zhang H,Liu Y,Gu Q,Xu J,Huang X,She Z

更新日期：2018-03-01 00:00:00

abstract：:Four new compounds, including three new steroids (1-3) and one new sesquiterpene (6), and two new natural products (4-5), as well as three known steroids (7-9) were isolated from the twigs of Turraea pubescens. Compounds 3-5 are C₂₂ steroids isolated from the Meliaceae family for the first time. Their structures were ...

journal_title：Fitoterapia

authors： Yuan CM,Tang GH,Wang XY,Zhang Y,Cao MM,Li XH,Li Y,Li SL,Di YT,He HP,Hao XJ,Hua HM

更新日期：2013-10-01 00:00:00

abstract：:Four new lathyrane-type diterpenoids (1-4) and a novel macrocyclic diterpenoid (5) featuring a 5/7/7/4-fused ring system, together with seventeen known ones (6-22), were isolated from the seeds of Euphorbia lathyris. Their structures were elucidated by extensive spectroscopic analyses and single crystal X-ray crystall...

journal_title：Fitoterapia

authors： Zuo Q,Mu HY,Gong Q,Ding X,Wang W,Zhang HY,Zhao WM

更新日期：2021-01-26 00:00:00