Subnudatones A and B, new trans-decalin polyketides from the cultured lichen mycobionts of Pseudopyrenula subnudata.


:Chemical investigation of the cultured polyspore-derived mycobionts of a Pseudopyrenula subnudata lichen led to the isolation of two new compounds, subnudatones A and B (1 and 2), together with four known compounds, 1-(2-hydroxy-1,2,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)ethanone (3), libertalide C (4), aspermytin A (5), and 6,7-dimethoxy-4-hydroxymellin (6). Their chemical structures were elucidated by extensive 1D and 2D NMR analysis and high resolution mass spectroscopy, and comparisons were made with the literature. The absolute configuration of 1 was defined unambiguously using single crystal X-ray crystallography. Compound 1 represents the first dimeric decalin polyketide to be found in nature. The in vitro cytotoxicity of 1 against two cancer cell lines (K562 and MCF-7) was evaluated. Compound 1 showed moderate cytotoxic activity with IC50 values of 23.5 ± 1.0 and 51.9 ± 1.4 μM, respectively.






Duong TH,Nguyen HH,Le TT,Tran TN,Sichaem J,Nguyen TT,Nguyen TP,Mai DT,Nguyen HH,Le HD




Has Abstract


2020-04-01 00:00:00












  • Triterpenoid saponins from the roots of Psammosilene tunicoides.

    abstract::Seven oleanane-type triterpenoid saponins, tunicosaponins B-D (1-3), F-I (4-7), along with eight known triterpenoid saponins (8-15), were isolated from the roots of Psammosilene tunicoides. The structures of compounds 1-7 were determined by comprehensive spectroscopic analysis, including 1D and 2D NMR techniques, mass...


    pub_type: 杂志文章


    authors: Wen B,Tian JM,Huang ZR,Xiao SJ,Yuan WL,Wang JX,Li HL,Xu XK,Shen YH

    更新日期:2020-07-01 00:00:00

  • Growth responses of Cassia obtusifolia toward human intestinal bacteria.

    abstract::1,2-Dihydroxyanthraquinone (1) was isolated from the seed of Cassia obtusifolia through bioassay-guided fractionation. 1,2-Dihydroxyanthraquinone strongly inhibited the growth of Clostridium perfringens and Escherichia coli. Structure-activity relationship revealed that 1,4-dihydroxyanthraquinone (2) and 1,8-dihydroxy...


    pub_type: 杂志文章


    authors: Sung BK,Kim MK,Lee WH,Lee DH,Lee HS

    更新日期:2004-07-01 00:00:00

  • Armillaramide, a new sphingolipid from the fungus Armillaria mellea.

    abstract::A new C(18)-phytosphingosine ceramide containing non-hydroxy fatty acid, armillaramide (1), has been isolated together with ergosterol peroxide from the fruiting bodies of the basidiomycete Armillaria mellea. Its structure was established as (2S,3S,4R)-2-hexadecanoylamino-octadecane-1,3,4-triol by spectroscopic and ch...


    pub_type: 杂志文章


    authors: Gao JM,Yang X,Wang CY,Liu JK

    更新日期:2001-12-01 00:00:00

  • Insecticidal activity and mechanism of cinnamaldehyde in C. elegans.

    abstract::Cinnamon is the dried bark of Cinnamomum cassia Presl, and its main component is cinnamaldehyde (CA). Decades of synthetic pesticide use to control parasitic nematodes that can harm plants has seriously polluted the environment and poses a risk to soil ecology, highlighting the need to develop natural biological pesti...


    pub_type: 杂志文章


    authors: Lu L,Shu C,Chen L,Yang Y,Ma S,Zhu K,Shi B

    更新日期:2020-10-01 00:00:00

  • Four new quassinoids from the roots of Eurycoma longifolia Jack.

    abstract::Seven compounds were isolated from the roots of Eurycoma longifolia, and characterized by comprehensive analysis of 1D and 2D NMR experiments along with single crystal X-ray diffraction. Among them, four new quassinoids were identified and three of them were diastereomers for each other. Compounds 1-7 were evaluated f...


    pub_type: 杂志文章


    authors: Meng D,Li X,Han L,Zhang L,An W,Li X

    更新日期:2014-01-01 00:00:00

  • Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis.

    abstract::Four new eburnamine-aspidospermine type bisindole alkaloids, namely, mekongenines C-F (1-4), along with 27 known indole alkaloids were isolated from the twigs and leaves of Bousigonia mekongensis. Their structures with the absolute configurations were elucidated by spectroscopic methods and ECD analyses. All new compo...


    pub_type: 杂志文章


    authors: Fu YH,Li SL,Li SF,He HP,Di YT,Zhang Y,Hao XJ

    更新日期:2014-10-01 00:00:00

  • Metabolism mediated interaction of α-asarone and Acorus calamus with CYP3A4 and CYP2D6.

    abstract::The present study was aimed to investigate the possible interaction of the standardized extract of Acorus calamus (AC) with Cytochrome P450 enzyme, quantitative determination of the α-asarone in the AC rhizome was performed by RP-HPLC method. In vitro interaction of the plant extract was evaluated by CYP450-carbon mon...


    pub_type: 杂志文章


    authors: Pandit S,Mukherjee PK,Ponnusankar S,Venkatesh M,Srikanth N

    更新日期:2011-04-01 00:00:00

  • Immunopharmacological properties of flavonoids.

    abstract::The flavonoids are a heterogeneous group of ubiquitous plant polyphenols that abound in the human diet and are endowed with several biological activities, including immunomodulating and antioxidant activities. The bioactivity of flavonoids is tightly correlated with their chemical structure and action mechanisms, most...


    pub_type: 杂志文章


    authors: Ielpo MT,Basile A,Miranda R,Moscatiello V,Nappo C,Sorbo S,Laghi E,Ricciardi MM,Ricciardi L,Vuotto ML

    更新日期:2000-08-01 00:00:00

  • Antimicrobial activity of plant extract Ankaferd Blood Stopper.

    abstract::The in vitro antimicrobial activity of Ankaferd Blood Stopper (ABS) was assessed on 102 clinical isolates from both Gram negative and Gram positive bacteria and four standard strains, including MRSA ATCC 43300, MSSA ATCC 25923, P. aeruginosa ATCC 27853 and E. coli ATCC 35218. ABS was significantly active against all b...


    pub_type: 杂志文章


    authors: Tasdelen Fisgin N,Tanriverdi Cayci Y,Coban AY,Ozatli D,Tanyel E,Durupinar B,Tulek N

    更新日期:2009-01-01 00:00:00

  • New monoterpene glycosides from Paeonia lactiflora.

    abstract::Three new monoterpene glycosides named 4-O-methyl-paeoniflorin (1), isopaeoniflorin (2), and isobenzoylpaeoniflorin (3), together with two known monoterpene glycosides, paeoniflorin (4) and benzoylpaeoniflorin (5), were isolated from the roots of Paeonia lactiflora. Their structures were established on the basis of sp...


    pub_type: 杂志文章


    authors: Braca A,Kiem PV,Yen PH,Nhiem NX,Quang TH,Cuong NX,Minh CV

    更新日期:2008-02-01 00:00:00

  • Effects of Erigeron breviscapus ethanol extract on neuronal oxidative injury induced by superoxide radical.

    abstract::Antioxidant activity of the ethanol extract of Erigeron breviscapus (EEEB) were studied by using neuron oxidative injury model induced by superoxide radical. EEEB at the dose of 10-140 mug/ml reduced significantly the lipid peroxidation levels and lactic dehydrogenase (LDH) release from neuron exposed to superoxide ra...


    pub_type: 杂志文章


    authors: Liu H,Yang X,Ren T,Feng Y,Xu H

    更新日期:2005-12-01 00:00:00

  • Phytochemistry and biological properties of glabridin.

    abstract::Glabridin, a prenylated isoflavonoid of G. glabra L. roots (European licorice, Fabaceae), has been associated with a wide range of biological properties such as antioxidant, anti-inflammatory, anti-atherogenic, regulation of energy metabolism, estrogenic, neuroprotective, anti-osteoporotic, and skin-whitening. While g...


    pub_type: 杂志文章,评审


    authors: Simmler C,Pauli GF,Chen SN

    更新日期:2013-10-01 00:00:00

  • Ancistroyafungines A-D, 5,8'- and 5,1'-coupled naphthylisoquinoline alkaloids from a Congolese Ancistrocladus species, with antiausterity activities against human PANC-1 pancreatic cancer cells.

    abstract::Four new naphthylisoquinoline alkaloids, the 5,8'-coupled ancistroyafungines A-C (1-3) and the 5,1'-linked ancistroyafungine D (4), have been isolated from the stem bark of an as yet unidentified Ancistrocladus (Ancistrocladaceae) liana recently discovered near the village Yafunga, in the North-Central region of the D...


    pub_type: 杂志文章


    authors: Kavatsurwa SM,Lombe BK,Feineis D,Dibwe DF,Maharaj V,Awale S,Bringmann G

    更新日期:2018-10-01 00:00:00

  • The antiadhesive activity of cranberry phytocomplex studied by metabolomics: Intestinal PAC-A metabolites but not intact PAC-A are identified as markers in active urines against uropathogenic Escherichia coli.

    abstract::Cranberry procyanidins and quercetin derivatives are considered possible active compounds against urinary tract infections (UTIs). In this paper a small group (n=6) of healthy subjects consumed a product containing 360mg of cranberry extract (42.6% w/w of PAC-A and 14.6% w/w of PAC-B) and 200mg of quercetin. Urine sam...


    pub_type: 杂志文章


    authors: Peron G,Sut S,Pellizzaro A,Brun P,Voinovich D,Castagliuolo I,Dall'Acqua S

    更新日期:2017-10-01 00:00:00

  • Antifungal limonoids from the fruits of Khaya senegalensis.

    abstract::Investigation of the fruits of Khaya senegalensis resulted in the isolation of three new mexicanolide limonoids containing a rare conjugated diene lactone system named seneganolide A (1), 2-hydroxyseneganolide A (2) and 2-acetoxyseneganolide A (3). Two known limonoids, 3-deacetyl-7-deacetoxy-7-oxokhivorin (4) and meth...


    pub_type: 杂志文章


    authors: Abdelgaleil SA,Iwagawa T,Doe M,Nakatani M

    更新日期:2004-09-01 00:00:00

  • A review on osteoclast diseases and osteoclastogenesis inhibitors recently developed from natural resources.

    abstract::Natural products have been investigated as potential candidates of novel therapeutics and play a crucial role in advanced medicinal drugs. Natural resources, including local medicinal plants (especially folk medicinal plants), animals, bacteria, and fungi have been used for more than a century, and are precious gifts ...


    pub_type: 杂志文章,评审


    authors: Wang X,Yamauchi K,Mitsunaga T

    更新日期:2020-04-01 00:00:00

  • Sesquiterpenes from cultures of the fungus Phellinus igniarius and their Cytotoxicities.

    abstract::Four new sesquiterpenoids, phellinignins A-D (1-4), together with four known ones (5-8), were isolated from cultures of the fungus Phellinus igniarius. The structures were established by extensive spectroscopic methods including MS, NMR, and the single crystal X-ray diffraction. Compounds 1-3 and 5-8 are tremulane ses...


    pub_type: 杂志文章


    authors: Wu PF,Ding R,Tan R,Liu J,Hu EM,Li CY,Liang GY,Yi P

    更新日期:2020-01-01 00:00:00

  • Chemical structures and cytotoxic activities of the constituents isolated from Hibiscus tiliaceus.

    abstract::Five new cadinene-type sesquiterpenes, hibiscusterpenes I-V (1-5), and six known compounds (6-11) have been isolated from the methanol extract of the stems and the twigs of Hibiscus tiliaceus. The structures of the new compounds were elucidated based on chemical and spectroscopic evidence. The absolute stereochemistry...


    pub_type: 杂志文章


    authors: Μatsumoto T,Imahori D,Achiwa K,Saito Y,Ohta T,Yoshida T,Kojima N,Yamashita M,Nakayama Y,Watanabe T

    更新日期:2020-04-01 00:00:00

  • Lycocasuarines I-Q, new Lycopodium alkaloids isolated from Lycopodiastrum casuarinoides.

    abstract::Lycocasuarines I-Q (1-9), nine new lycodine-type Lycopodium alkaloids were isolated from the aerial parts of Lycopodiastrum casuarinoides (Spring) Holub ex R.D.Dixit. Their structures were unambiguously determined via extensive spectroscopic analyses, including HRESIMS, NMR, and electronic circular dichroism (ECD). Th...


    pub_type: 杂志文章


    authors: Zhu XL,Wang LL,Shi ZH,Xia D,Zhou ZB,Pan K

    更新日期:2019-04-01 00:00:00

  • New steroids from Clerodendrum colebrookianum.

    abstract::Five new steroids, colebrin A-E (1-5) were isolated from the aerial parts of Clerodendrum colebrookianum. The structures of the new compounds were elucidated on the basis of spectral evidence. ...


    pub_type: 杂志文章


    authors: Yang H,Wang J,Hou AJ,Guo YP,Lin ZW,Sun HD

    更新日期:2000-12-01 00:00:00

  • A new chiratane type triterpenoid from the rhizomes of Drynaria fortunei.

    abstract::Chiratone (1), a rare new chiratane type triterpenoid, together with five known triterpenoids were isolated from the rhizomes of Drynaria fortunei (Kunze) J. Sm. The structure was characterized as 20β-hydroxychiratan-22-one on the basis of extensive 1D and 2D NMR, and MS spectroscopic analyses, and was further confirm...


    pub_type: 杂志文章


    authors: Liang YH,Wang W,Yu SW,Ye M,He XH,Gong NB,Lu Y,Khan IA,Guo DA

    更新日期:2010-12-01 00:00:00

  • Diplacone and mimulone ameliorate dextran sulfate sodium-induced colitis in rats.

    abstract::Diplacone (1) and mimulone (2), two geranylated flavanones, have previously shown anti-inflammatory and antiradical activity in vitro. The present study aimed to evaluate their activity in vivo on a model of colitis induced in Wistar rats by an oral administration of dextran sulfate sodium (DSS). Diplacone (1) and mim...


    pub_type: 杂志文章


    authors: Vochyánová Z,Bartošová L,Bujdáková V,Fictum P,Husník R,Suchý P,Šmejkal K,Hošek J

    更新日期:2015-03-01 00:00:00

  • Anti-inflammatory and analgesic properties of cis-mulberroside A from Ramulus mori.

    abstract::This study examined the analgesic and anti-inflammatory actions of cis-mulberroside A isolated from Ramulus mori in several models of inflammatory pain in mice. Cis-mulberroside A (25 and 50mg/kg) given by p.o. route 30 min before challenge produced a dose-dependent inhibition of the acetic acid-induced pain and Evans...


    pub_type: 杂志文章


    authors: Zhang Z,Shi L

    更新日期:2010-04-01 00:00:00

  • Sesquiterpenoids from the seeds of Sarcandra glabra and the potential anti-inflammatory effects.

    abstract::Five new sesquiterpenoids, including two linderanes (1-2) and three eudesmanes (3-5) were isolated from the seeds of Sarcandra glabra. Their structures and relative configurations were established by spectroscopic data analysis. 1 was a rare linderane derivative having an 18-membered triester ring which is a common ch...


    pub_type: 杂志文章


    authors: Yaermaimaiti S,Wang P,Luo J,Li RJ,Kong LY

    更新日期:2016-06-01 00:00:00

  • Cinchonicine-derived alkaloids from the bark of the Peruvian Ladenbergia oblongifolia.

    abstract::The isolation of cinchonicine-derived alkaloids epicinchonicinol (1), cinchonidicinol (2) and a mixture of dihydrocinchonicinol and dihydrocinchonidicinol (3) from the dried bark of Ladenbergia oblongifolia, is reported along with (1)H and (13)C-NMR data. ...


    pub_type: 杂志文章


    authors: Okunade AL,Lewis WH,Elvin-Lewis MP,Casper SJ,Goldberg DE

    更新日期:2001-08-01 00:00:00

  • Chiral resolution and bioactivity of enantiomeric benzofuran neolignans from the fruit of Rubus ideaus L.

    abstract::Rubus ideaus L., a member of the Rosaceae family, is popular for its distinctive flavor and attractive red color. In order to explore the functional factors possibly presented in the fruit, seven new benzofuran neolignans (1a/1b-3a/3b and 4b), together with one known neolignan 4a, were isolated from the fruit of R. id...


    pub_type: 杂志文章


    authors: Zhou L,Xi YF,Wang W,Lin B,Wang XB,Huang XX,Song SJ

    更新日期:2018-06-01 00:00:00

  • Isoflavone content and estrogenic activity of different batches of red clover (Trifolium pratense L.) extracts: an in vitro study in MCF-7 cells.

    abstract::The estrogenicity of different batches of red clover (Trifolium pratense L., Fabaceae; RCL) extracts and its relationship with the isoflavone content were assessed by measuring MCF-7 cell proliferation by flow cytometry and propidium iodide staining. RCL extracts were compared to estradiol (E2) and to the main RCL iso...


    pub_type: 杂志文章


    authors: Spagnuolo P,Rasini E,Luini A,Legnaro M,Luzzani M,Casareto E,Carreri M,Paracchini S,Marino F,Cosentino M

    更新日期:2014-04-01 00:00:00

  • Accuracy, precision, and reliability of chemical measurements in natural products research.

    abstract::Natural products chemistry is the discipline that lies at the heart of modern pharmacognosy. The field encompasses qualitative and quantitative analytical tools that range from spectroscopy and spectrometry to chromatography. Among other things, modern research on crude botanicals is engaged in the discovery of the ph...


    pub_type: 杂志文章,评审


    authors: Betz JM,Brown PN,Roman MC

    更新日期:2011-01-01 00:00:00

  • Novel anti-tumour barringenol-like triterpenoids from the husks of Xanthoceras sorbifolia Bunge and their three dimensional quantitative structure activity relationships analysis.

    abstract::The high edible oil content of Xanthoceras sorbifolia Bunge seeds contributes to its economic value. In this study, we analysed the barrigenol-like triterpenoids derived from X. sorbifolia husks. We also identified anti-tumour agents that could enhance the health benefits and medicinal value of X. sorbifolia. We isola...


    pub_type: 杂志文章


    authors: Wang D,Su D,Yu B,Chen C,Cheng L,Li X,Xi R,Gao H,Wang X

    更新日期:2017-01-01 00:00:00

  • Steroidal saponins from the leaves of Agave macroacantha.

    abstract::A new monodesmosidic spirostanol saponin, along with three known saponins was isolated from Agave macroacantha Zucc leaves. The structure of the new saponin was established as hecogenin-3-O-alpha-L-rhamnopyranosyl (1-->4) beta-D-xylopyranosyl (1-->3)[beta-D-glucopyranosyl (1-->2)] beta-D-glucopyranosyl (1-->4) beta-D-...


    pub_type: 杂志文章


    authors: Eskander J,Lavaud C,Harakat D

    更新日期:2010-07-01 00:00:00