Anti-inflammatory and analgesic properties of cis-mulberroside A from Ramulus mori.

Abstract:

:This study examined the analgesic and anti-inflammatory actions of cis-mulberroside A isolated from Ramulus mori in several models of inflammatory pain in mice. Cis-mulberroside A (25 and 50mg/kg) given by p.o. route 30 min before challenge produced a dose-dependent inhibition of the acetic acid-induced pain and Evans blue leakage in mice. In addition, this compound exhibited significant systemic anti-inflammatory activity in carrageenan-induced mouse paw edema in a concentration-related manner (33.1-68.5% inhibition), and similar results were achieved in formalin test. Suppressive effects of cis-mulberroside A on the production of NO and expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-stimulated macrophages were also assessed. Collectively, cis-mulberroside A showed high analgesic and anti-inflammatory activities. The above results will be the supporting evidence for the potential anti-rheumatoid activity of R.mori in Chinese traditional medicine.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Zhang Z,Shi L

doi

10.1016/j.fitote.2009.09.005

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

214-8

issue

3

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(09)00219-6

journal_volume

81

pub_type

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