当前位置： SCI文献检索 > FITOTERAPIA期刊下所有文献 > Racemic meroterpenoids from Ganoderma cochlear.

Racemic meroterpenoids from Ganoderma cochlear.

Abstract：

:Ganoderma cochlear, as edible and medicinal fungus, has long been used to prevent and treat various diseases. As our continuously phytochemical investigation of this fungus, a HPLC-UV-guided method led to the isolation of nine previously undescribed aromatic meroterpenoids with different ring systems, including six pairs of racemates, (±)-cochlearins A-E, G (1-5, 7), and three new analogues, cochlearins F, H and I (6, 8, 9). Their structures were elucidated by extensive 1D, 2D NMR spectroscopic data and MS analyses. The stereostructures of (±)-cochlearins A and B (1 and 2) were assigned using electronic circular dichroism (ECD) calculations. All of the isolates showed comparable antioxidant activities with IC50 values of 3.1 ± 0.1-5.3 ± 0.1 μM, compared to the positive control (trolox, IC50: 3.3 ± 0.1 μM). (±)-Cochlearin D (4) and (+)-4 exhibited weak inhibitory effects for the proliferation of hepatic stellate cells (HSCs) induced by transforming growth factor-β1 (TGF-β1).

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Peng X,Wang X,Chen L,Yang H,Li L,Lu S,Zhou L,Qiu M

doi

10.1016/j.fitote.2018.03.005

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

286-292

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(18)30206-5

journal_volume

127

pub_type

杂志文章

相关文献

FITOTERAPIA文献大全
  • A new eudesmane derivative from Onopordon ambiguum.

    abstract：:Reinvestigation of Onopordon ambiguum extract afforded a new eudesmane derivative 1, in addition to the known elemanoid derivative 2. The structures of both compounds were determined by spectroscopic techniques, including 1H-, 13C-NMR, DEPT, 1H-1H and 1H-13C COSY analysis. ...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/s0367-326x(01)00366-5

    authors： El-Moghazy SA,Ahmed AA,Abdel-Ghani HF,El-Shanawany MA

    更新日期：2002-02-01 00:00:00

  • The chemical composition of the pharmacologically active Thymus species, its antibacterial activity against Streptococcus mutans and the antiadherent effects of T. vulgaris on the bacterial colonization of the in situ pellicle.

    abstract：:The pharmacological active genus Thymus L. comprises over 200 species. Besides its traditional pharmacological use, thyme may reduce the risk of caries disease, however, there is very little respective literature. The pharmacological effects can be attributed to the secondary plant metabolites. The composition of the ...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2017.07.005

    authors： Schött G,Liesegang S,Gaunitz F,Gleß A,Basche S,Hannig C,Speer K

    更新日期：2017-09-01 00:00:00

  • 2-(2-Phenylethyl)chromone derivatives in artificial agarwood from Aquilaria sinensis.

    abstract：:Seven new 2-(2-phenylethyl)chromone derivatives (1-7) including a chlorinated one (4), together with eight known ones (8-15), were isolated from the EtOAc extract of artificial agarwood originating from Aquilaria sinensis (Lour.) Gilg. All structures including the absolute configurations were unambiguously elucidated ...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2016.01.011

    authors： Liao G,Mei WL,Dong WH,Li W,Wang P,Kong FD,Gai CJ,Song XQ,Dai HF

    更新日期：2016-04-01 00:00:00

  • New metabolites of acteoside identified by ultra-performance liquid chromatography/quadrupole-time-of-flight MS(E) in rat plasma, urine, and feces.

    abstract：:Acteoside, which belongs to the family of phenylethanoid glycosides (PhGs), has extensive biological activities, including strong antioxidant, anti-inflammatory, hepatoprotect, and cell apoptosis regulation. Like other PhGs compounds, the fate of acteoside in the gut for both parent polyphenols and their degradation p...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2016.05.004

    authors： Su D,Li W,Xu Q,Liu Y,Song Y,Feng Y

    更新日期：2016-07-01 00:00:00

  • Cytotoxic cochlioquinone derivatives from the endophytic fungus Bipolaris sorokiniana derived from Pogostemon cablin.

    abstract：:Chemical investigation of the liquid culture of the endophytic fungus Bipolaris sorokiniana A606, which was isolated from the medicinal plant Pogostemon cablin resulted in the isolation of four new cytotoxic compounds, named isocochlioquinones D-E (1-2) and cochlioquinones G-H (3-4), along with five known cochlioquino...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2016.02.005

    authors： Wang M,Sun ZH,Chen YC,Liu HX,Li HH,Tan GH,Li SN,Guo XL,Zhang WM

    更新日期：2016-04-01 00:00:00

  • Novel tirucallane triterpenoids from the stem bark of Toona sinensis.

    abstract：:Phytochemical investigation on the stem bark of Toona sinensis was carried out by various chromatographic techniques resulting in the isolation and elucidation of two novel tirucallane triterpenoids, named (20S)-3-oxo-tirucalla-25-nor-7-en-24-oic acid (1) and (20S)-5α,8α-epidioxy-3-oxo-24-nor-6.9(11)-dien-23-oic acid ...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2016.05.009

    authors： Tang J,Xu J,Zhang J,Liu WY,Xie N,Chen L,Feng F,Qu W

    更新日期：2016-07-01 00:00:00

  • Biotransfomation of cyperenoic acid by Cunninghamella elegans AS 3.2028 and the potent anti-angiogenic activities of its metabolites.

    abstract：:Cyperenoic acid (1) is one of the major sesquiterpenes isolated from Croton crassifolius, which exhibited potent anti-angiogenic activity. Traditional structural modification of 1 is difficult to perform by chemical technology due to the remarkable stability of the patchoulane skeleton. In order to overcome chemical s...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2017.02.004

    authors： Chen Y,Tian JL,Wu JS,Sun TM,Zhou LN,Song SJ,You S

    更新日期：2017-04-01 00:00:00

  • Carboxymethyl flavonoids and a chromone with antimicrobial activity from Selaginella moellendorffii Hieron.

    abstract：:Five new carboxymethyl flavonoids named 5-carboxymethyl-3', 4', 7-trihydroxyflavone (1), (2S)- 5-carboxymethyl-3', 4', 7-trihydroxyflavonone (2a), (2R)-5-carboxymethyl-3', 4', 7-trihydroxyflavonone (2b), (2S)-5-carboxymethyl-4', 7-dihydroxyflavonone (3), 5- carbomethoxymethyl-4', 7-dihydroxyflavone (4), and a new chro...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2016.04.022

    authors： Zou Z,Xu P,Wu C,Zhu W,Zhu G,He X,Zhang G,Hu J,Liu S,Zeng W,Xu K,Tan G

    更新日期：2016-06-01 00:00:00

  • Miscellaneous lanostane triterpenoids with cytotoxicities from fruiting bodies of the basidiomycete Stereum sp.

    abstract：:Ten new highly oxygenated lanostane triterpenoids, stereinones A-J (1-10), were isolated from the fruiting bodies of the basidiomycete Stereum sp. Compounds 3 and 4 are structurally characterized as intact lanostane-type triterpenoids containing unusual 1,2-diketone functionality at C-11 and C-12, while compound 10 is...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2017.11.020

    authors： Yao JN,Chen L,Chen HP,Zhao ZZ,Zhang SB,Huang Y,Tang Y,Isaka M,Li ZH,Feng T,Liu JK

    更新日期：2018-03-01 00:00:00

  • Aspergilates A to E, second metabolites from Aspergillus sp. isolated from Paeonia ostii.

    abstract：:Five novel globoscinic acid derivatives, aspergilates A-E (1-5) have been isolated from endophytic fungus Aspergillus sp. derived from Paeonia ostii. The structures of aspergilates A-E were determined by in-depth analyses of NMR spectra, HRESIMS and CD experiments. The absolute configurations of compounds 2-5 were det...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2018.10.027

    authors： Wang JT,Zhang PL,Liu JS,Wang GK,Xu FQ,Chen L,Yu Y,Wang G

    更新日期：2018-11-01 00:00:00

  • Stilbenes with anti-inflammatory and cytotoxic activity from the rhizomes of Bletilla ochracea Schltr.

    abstract：:Four new dihydrophenanthrenofuran, bleochranols A-D (1-4), along with 21 known compounds including phenanthrenes (5-14) and bibenzyls (15-25) were isolated and elucidated from the rhizomes of Bletilla ochracea. Combination of 1D/2D NMR techniques and the Electronic Circular Dichroism (ECD) spectroscopy based on the em...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2018.02.007

    authors： Li JY,Kuang MT,Yang L,Kong QH,Hou B,Liu ZH,Chi XQ,Yuan MY,Hu JM,Zhou J

    更新日期：2018-06-01 00:00:00

  • Seladoeflavones A-F, six novel flavonoids from Selaginella doederleinii.

    abstract：:Six new flavonoids, seladoeflavones A-F (1-6), were isolated from the whole herbs of Selaginella doederleinii, together with one known flavonoid (7). Their structures including absolute configuration were characterized on the basis of extensive spectroscopic methods including NMR, HRMS, and electronic circular dichroi...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2016.11.014

    authors： Zou Z,Xu K,Xu P,Li X,Cheng F,Li J,Yu X,Cao D,Li D,Zeng W,Zhang G,Tan G

    更新日期：2017-01-01 00:00:00

  • New ursane-type triterpenoids from Clerodendranthus spicatus.

    abstract：:Five new ursane-type triterpenoids, spicatusoids A-E (1, 3-6), and three known ones (2, 7, and 8), and a known oleanane-type triterpenoid (9) were isolated from the aerial parts of Clerodendranthus spicatus. Their structures were elucidated by spectroscopic methods. In particular, the structure of 3 including its abso...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2017.04.001

    authors： Luo Y,Cheng LZ,Luo Q,Yan YM,Wang SM,Sun Q,Cheng YX

    更新日期：2017-06-01 00:00:00

  • Herbal extracts, lichens and biomolecules as natural photo-protection alternatives to synthetic UV filters. A systematic review.

    abstract：:Besides the unquestionable positive effects of solar exposure for human health, UV rays have been widely investigated for toxicology aspects related to excessive UVB and UVA doses, which involve sunburns, skin aging, DNA skin damage and tumorigenesis. At present, synthetic and mineral sunscreens are used to protect ag...

    journal_title：Fitoterapia

    pub_type： 杂志文章,评审

    doi：10.1016/j.fitote.2016.09.003

    authors： Radice M,Manfredini S,Ziosi P,Dissette V,Buso P,Fallacara A,Vertuani S

    更新日期：2016-10-01 00:00:00

  • New isocoumarins and alkaloid from Chinese insect medicine, Eupolyphaga sinensis Walker.

    abstract：:Two new isocoumarins (1 and 2), a new alkaloid (3), and a known N-acetyldopamine dimer (4) were isolated from the ethyl acetate extract of Chinese insect medicine Eupolyphaga sinensis. Their structures were elucidated on the basis of detailed spectroscopic investigations, such as 1D- and 2D NMR spectroscopy, as well a...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2012.06.005

    authors： Jiang HL,Luo XH,Wang XZ,Yang JL,Yao XJ,Crews P,Valeriote FA,Wu QX

    更新日期：2012-10-01 00:00:00

  • Antimicrobial activity of the Derris elliptica, Derris indica and Derris trifoliata extractives.

    abstract：:Various parts of Derris elliptica, Derris indica and Derris trifoliata on fractionation with a number of solvents (petrol, dichloromethane, ethyl acetate, butanol and methanol) gave fractions which demonstrated a varied level of broad spectrum antibacterial activity. Good activity was exhibited by the methanol fractio...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2006.03.007

    authors： Khan MR,Omoloso AD,Barewai Y

    更新日期：2006-06-01 00:00:00

  • Dihydro-β-agarofuran sesquiterpenoid derivatives with neuroprotective activity from the leaves of Tripterygium wilfordii.

    abstract：:A phytochemical investigation on the leaves of Tripterygium wilfordii Hook. F. was conducted, leading to the isolation of five undescribed dihydro-β-agarofuran sesquiterpenoids (1-5) and one known analogue (6). Their structures were determined by comprehensive spectroscopic analyses. The absolute configurations of the...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2020.104501

    authors： Zhao P,Lin B,Hou ZL,Zhou L,He QJ,Yao GD,Huang XX,Song SJ

    更新日期：2020-04-01 00:00:00

  • Antiulcer activity of Mikania cordata.

    abstract：:The alkaloidal fraction obtained from an ethanolic extract of the leaves of Mikania cordata exhibited significant in vivo antiulcer activity in diclofenac sodium-induced gastric erosions in Long Evans rats. ...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/s0367-326x(00)00216-1

    authors： Paul RK,Jabbar A,Rashid MA

    更新日期：2000-12-01 00:00:00

  • Antibacterial activity of Enantia polycarpa bark.

    abstract：:Antimicrobial screening of Enantia polycarpa bark showed activity of the polar extracts against some microorganisms. ...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/s0367-326x(99)00153-7

    authors： Ajali U

    更新日期：2000-06-01 00:00:00

  • Grapefruit: the last decade acquisitions.

    abstract：:This review reports the last decade acquisitions on grapefruit. New coumarins and limonoids were isolated and characterised. The bioavailability of many drugs was tested with grapefruit juice (GJ) coadministration; the inhibition on cytochrome P450 seems due to a synergic action between flavonoids and coumarins. Antim...

    journal_title：Fitoterapia

    pub_type： 杂志文章,评审

    doi：10.1016/s0367-326x(00)00176-3

    authors： Tirillini B

    更新日期：2000-08-01 00:00:00

  • Evaluation of the anti-microbial and anti-inflammatory activities of the medicinal plants Dodonaea viscosa, Rumex nervosus and Rumex abyssinicus.

    abstract：:The crude extracts of the leaves of Dodonaea viscosa and Rumex nervosus as well as of the root of Rumex abyssinicus were tested for anti-microbial and anti-inflammatory activities. It was observed that the three plants possess antibacterial activity against Streptococcus pyogenes and Staphylococcus aureus and strong a...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/s0367-326x(02)00315-5

    authors： Getie M,Gebre-Mariam T,Rietz R,Höhne C,Huschka C,Schmidtke M,Abate A,Neubert RH

    更新日期：2003-02-01 00:00:00

  • Antimicrobial evaluation of myricetin derivatives containing benzimidazole skeleton against plant pathogens.

    abstract：:A series of novel myricetin derivatives containing benzimidazole skeleton were constructed. The structure of compound 4g was further corroborated via X-ray single crystal diffractometer. The antimicrobial bioassays showed that all compounds exhibited potent inhibitory activities against Xanthomonas axonopodis pv. Citr...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2020.104804

    authors： Chen M,Tang X,Liu T,Peng F,Zhou Q,Luo H,He M,Xue W

    更新日期：2020-12-11 00:00:00

  • In vivo metabolism of 8,2'-diprenylquercetin 3-methyl ether and the distribution of its metabolites in rats by HPLC-ESI-IT-TOF-MSn.

    abstract：:8,2'-Diprenylquercetin 3-methyl ether, a natural product with prominent anti-breast cancer activity, is the main active constituent of Sinopodophylli Fructus. A high-performance liquid chromatography with a diode array detector coupled with electrospray ionization ion trap time-of-flight multistage mass spectrometry (...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2019.104191

    authors： Ma LM,Xu F,Wang JZ,Shang MY,Liu GX,Cai SQ

    更新日期：2019-09-01 00:00:00

  • Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis.

    abstract：:Four new eburnamine-aspidospermine type bisindole alkaloids, namely, mekongenines C-F (1-4), along with 27 known indole alkaloids were isolated from the twigs and leaves of Bousigonia mekongensis. Their structures with the absolute configurations were elucidated by spectroscopic methods and ECD analyses. All new compo...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2014.07.008

    authors： Fu YH,Li SL,Li SF,He HP,Di YT,Zhang Y,Hao XJ

    更新日期：2014-10-01 00:00:00

  • Hyaluronidase and protease activities from Indian snake venoms: neutralization by Mimosa pudica root extract.

    abstract：:The aqueous root extract of Mimosa pudica dose dependently inhibited the hyaluronidase and protease activities of Indian snakes (Naja naja, Vipera russelii and Echis carinatus) venom. ...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2004.01.006

    authors： Girish KS,Mohanakumari HP,Nagaraju S,Vishwanath BS,Kemparaju K

    更新日期：2004-06-01 00:00:00

  • Terpenoids from Curcuma wenyujin increased glucose consumption on HepG2 cells.

    abstract：:Thirty four terpenoids, including two new cadinane-type sesquiterpenoids containing conjugated aromatic-ketone moieties, curcujinone A (1) and curcujinone B (2), were isolated from 95% ethanol extract of the root tubers of Curcuma wenyujin. Their structures were determined by spectroscopic methods, especially 2D NMR a...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2017.06.011

    authors： Zhou CX,Zhang LS,Chen FF,Wu HS,Mo JX,Gan LS

    更新日期：2017-09-01 00:00:00

  • Cytoprotectivity of Prunella vulgaris on doxorubicin-treated rat cardiomyocytes.

    abstract：:The cardioprotective effect of Prunella vulgaris ethylacetate fraction (PVEF) and its constituent rosmarinic acid (RA) was evaluated on isolated rat cardiomyocytes subjected to doxorubicin-induced oxidative stress. The cytoprotectivities of PVEF and RA were concentration-dependent in the range of 0.005 to 0.05 mg/ml a...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2005.04.019

    authors： Psotová J,Chlopcíková S,Miketová P,Simánek V

    更新日期：2005-09-01 00:00:00

  • A new arylnaphthalene lignan from Knema furfuracea.

    abstract：:A new arylnaphthalene lignan, named furfuracin, was isolated from the leaves of Knema furfuracea (Myristicaceae), whereas 7 known compounds including (+)-trans-1,2-dihydrodehydroguaiaretic acid, fragransin A(2), biochanin A, gingkolic acid, anarcardic acid, 2-hydroxy-6-(12-phenyldodecyl)-benzoic acid and 2-hydroxy-6-(...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2009.05.005

    authors： Rangkaew N,Suttisri R,Moriyasu M,Kawanishi K

    更新日期：2009-09-01 00:00:00

  • A phytochemical investigation of Alchornea latifolia.

    abstract：:A phytochemical investigation of the chloroform leaf extract of Alchornea latifolia has been undertaken. Along with the triterpenoids taraxerone, friedelin, epifriedelinol, and taraxerol, the plant also contains seco-3,4-friedelin (dihydroputranjivic acid) (1) and seco-3,4-taraxerone (2). These A-ring-opened triterpen...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/s0367-326x(99)00133-1

    authors： Setzer WN,Shen X,Bates RB,Burns JR,McClure KJ,Zhang P,Moriarity DM,Lawton RO

    更新日期：2000-04-01 00:00:00

  • Four new C18-diterpenoid alkaloids with analgesic activity from Aconitum weixiense.

    abstract：:Four new C18-diterpenoid alkaloids, weisaconitines A-D (1-4), were isolated from Aconitum weixiense. Based on extensive UV, IR, MS, 1D and 2D NMR analyses, their structures were elucidated as 8-O-ethyldolaconine (1), 4-demethylgenicunine B (2), 14-oxoaconosine (3), and 8-O-ethylaconosine (4). The analgesic activity of...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2013.09.013

    authors： Zhao DK,Ai HL,Zi SH,Zhang LM,Yang SC,Guo HC,Shen Y,Chen YP,Chen JJ

    更新日期：2013-12-01 00:00:00