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Biotransfomation of cyperenoic acid by Cunninghamella elegans AS 3.2028 and the potent anti-angiogenic activities of its metabolites.

Abstract：

:Cyperenoic acid (1) is one of the major sesquiterpenes isolated from Croton crassifolius, which exhibited potent anti-angiogenic activity. Traditional structural modification of 1 is difficult to perform by chemical technology due to the remarkable stability of the patchoulane skeleton. In order to overcome chemical synthesis difficulties and obtain structurally diverse derivations, microbial transformation of 1 by using Cunninghamella elegans AS 3.2028 was studied for the first time. Five new hydroxylated products 2-6 were obtained. Furthermore, cytotoxicity and anti-angiogenic activities of all the biotransformation products were evaluated by MTT assay and ELISA in HepG2 and MCF-7 cells. These results indicated that hydroxylated modification products 2-4 significantly inhibited VEGF release, which suggest the potential use of hydroxylated modification products for cancer therapy.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Chen Y,Tian JL,Wu JS,Sun TM,Zhou LN,Song SJ,You S

doi

10.1016/j.fitote.2017.02.004

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

32-37

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(17)30150-8

journal_volume

118

pub_type

杂志文章

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