Abstract：
:A phytochemical investigation on the leaves of Tripterygium wilfordii Hook. F. was conducted, leading to the isolation of five undescribed dihydro-β-agarofuran sesquiterpenoids (1-5) and one known analogue (6). Their structures were determined by comprehensive spectroscopic analyses. The absolute configurations of the compounds were determined by comparison of the experimental ECD with the calculated data. In addition, all the compounds were evaluated for their neuroprotective activities against H2O2-induced cell injury in human neuroblastoma SH-SY5Y cells, and 3 showed the better protective effect with 76.63% cell viability comparing with the positive control Trolox (69.84%) at 12.5 μM.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Zhao P,Lin B,Hou ZL,Zhou L,He QJ,Yao GD,Huang XX,Song SJdoi
10.1016/j.fitote.2020.104501subject
Has Abstractpub_date
2020-04-01 00:00:00pages
104501eissn
0367-326Xissn
1873-6971pii
S0367-326X(20)30083-6journal_volume
142pub_type
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