Dihydro-β-agarofuran sesquiterpenoid derivatives with neuroprotective activity from the leaves of Tripterygium wilfordii.


:A phytochemical investigation on the leaves of Tripterygium wilfordii Hook. F. was conducted, leading to the isolation of five undescribed dihydro-β-agarofuran sesquiterpenoids (1-5) and one known analogue (6). Their structures were determined by comprehensive spectroscopic analyses. The absolute configurations of the compounds were determined by comparison of the experimental ECD with the calculated data. In addition, all the compounds were evaluated for their neuroprotective activities against H2O2-induced cell injury in human neuroblastoma SH-SY5Y cells, and 3 showed the better protective effect with 76.63% cell viability comparing with the positive control Trolox (69.84%) at 12.5 μM.






Zhao P,Lin B,Hou ZL,Zhou L,He QJ,Yao GD,Huang XX,Song SJ




Has Abstract


2020-04-01 00:00:00












  • Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia.

    abstract::The effect of berberine hydrochloride (BBR) on inducible cyclooxygenase-2 (COX-2) in small intestinal mucosa and related mechanisms was investigated in a rat model of acute endotoxemia. The results showed that lipopolysaccharide (LPS) increased COX-2 expression, whereas SB202190 and BBR curtailed it. LPS increased pho...


    pub_type: 杂志文章


    authors: Feng AW,Yu C,Mao Q,Li N,Li QR,Li JS

    更新日期:2011-10-01 00:00:00

  • Sequence characterized amplified region (SCAR) analysis on DNA from the three medicinal Echinacea species.

    abstract::In our previous study, RAPD (Random Amplified Polymorphic DNA) analysis revealed species-specific markers for three medicinal Echinacea species (Asteraceae): E. angustifolia DC., E. pallida (Nutt.) Nutt. and E. purpurea (L.) Moench. In the present work, we have converted a RAPD marker (750 bp) for E. purpurea into a S...


    pub_type: 杂志文章


    authors: Adinolfi B,Chicca A,Martinotti E,Breschi MC,Nieri P

    更新日期:2007-01-01 00:00:00

  • Regulation of research: is it a drug trial or a supplement trial?

    abstract::Investigators and sponsors of dietary supplement research need to know the relevant regulatory requirements and how to comply with them. This brief review describes how research on dietary supplements is regulated by FDA. In general, whether an FDA sanctioned Investigational New Drug (IND) application is required for ...


    pub_type: 杂志文章,评审


    authors: Chen ST

    更新日期:2011-01-01 00:00:00

  • Cytotoxic and antioxidant dihydrobenzofuran neolignans from the seeds of Crataegus pinnatifida.

    abstract::Eight new dihydrobenzofuran neolignans, pinnatifidanin C I-VIII (1-8), together with two known analogs (9-10) were isolated from the seeds of Crataegus pinnatifida. Their structures were elucidated by spectroscopic analyses, especially 1D, 2D NMR and CD spectra. The cytotoxic activities of all isolates against human c...


    pub_type: 杂志文章


    authors: Huang XX,Zhou CC,Li LZ,Peng Y,Lou LL,Liu S,Li DM,Ikejima T,Song SJ

    更新日期:2013-12-01 00:00:00

  • Sesquiterpene coumarins from seeds of Ferula sinkiangensis.

    abstract::A new sesquiterpene coumarin with a novel sesquiterpene carbon framework, Sinkiangenorin D, and ten known sesquiterpene coumarins were isolated from the seeds of Ferula sinkiangensis. The structures of these compounds, including the relative stereochemistry, were elucidated on the basis of spectroscopic data. All of t...


    pub_type: 杂志文章


    authors: Li G,Li X,Cao L,Zhang L,Shen L,Zhu J,Wang J,Si J

    更新日期:2015-06-01 00:00:00

  • Honeybush (Cyclopia sp.) - a rich source of compounds with high antimutagenic properties.

    abstract::The genus Cyclopia (Fabaceae family) includes a number of shrubs endemic to Cape Fynbos region of South Africa. The most common of these plants is Cyclopia intermedia E. Mey., used together with other Cyclopia species (mainly C. subternata and C. sessiliflora) to manufacture the honeybush herbal tea which has been pro...


    pub_type: 杂志文章,评审


    authors: Kokotkiewicz A,Luczkiewicz M

    更新日期:2009-01-01 00:00:00

  • Five new benzylphenanthrenes from Cremastra appendiculata.

    abstract::Five new benzylphenanthrenes, cremaphenanthrenes L-P (1-5) were isolated from the EtOAc-soluble extract of the tubers of Cremastra appendiculata. Their structures were elucidated based on the spectroscopic data and chemical methods. Compounds 1-5 were tested in vitro for their cytotoxic effects against colon (HCT-116)...


    pub_type: 杂志文章


    authors: Liu L,Li J,Zeng KW,Jiang Y,Tu PF

    更新日期:2015-06-01 00:00:00

  • Antimicrobial and cytotoxicity evaluation of Buchholzia coriacea stem bark.

    abstract::Fractions prepared from the methanol extract of Buchholzia coriacea stem bark exhibited a high concentration-dependent antibacterial and antifungal activity compared to the standard antibiotics, ampicillin and tioconazole. In the brine shrimp lethality (BSL) assay, the methanol extract was found to be non-toxic with a...


    pub_type: 杂志文章


    authors: Ajaiyeoba EO,Onocha PA,Nwozo SO,Sama W

    更新日期:2003-12-01 00:00:00

  • A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia.

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    pub_type: 杂志文章


    authors: Lutz JA,Kulshrestha M,Rogers DT,Littleton JM

    更新日期:2014-10-01 00:00:00

  • Attenuation of stress-induced gastrointestinal motility disorder by gentiopicroside, from Gentiana macrophylla Pall.

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    pub_type: 杂志文章


    authors: Ruan M,Yu B,Xu L,Zhang L,Long J,Shen X

    更新日期:2015-06-01 00:00:00

  • Hirtellina lobelii DC. essential oil, its constituents, its combination with antimicrobial drugs and its mode of action.

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    pub_type: 杂志文章


    authors: Khoury M,El Beyrouthy M,Ouaini N,Eparvier V,Stien D

    更新日期:2019-03-01 00:00:00

  • Antimicrobial metabolites from the plant endophytic fungus Penicillium sp.

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    authors: Yang MH,Li TX,Wang Y,Liu RH,Luo J,Kong LY

    更新日期:2017-01-01 00:00:00

  • Native Australian plant extracts differentially induce Collagen I and Collagen III in vitro and could be important targets for the development of new wound healing therapies.

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    pub_type: 杂志文章


    authors: Adams DH,Shou Q,Wohlmuth H,Cowin AJ

    更新日期:2016-03-01 00:00:00

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    pub_type: 杂志文章


    authors: Venskutonis PR,Skemaite M,Ragazinskiene O

    更新日期:2007-02-01 00:00:00

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    更新日期:2017-11-01 00:00:00

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    pub_type: 杂志文章


    authors: Zhang Y,Cao Y,Zhan Y,Duan H,He L

    更新日期:2010-12-01 00:00:00

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    abstract::Phytochemical investigation of methanolic extract of the whole plants of Vaccinium emarginatum allowed for the characterization of one epicatechin derivative (1) that was isolated from a natural source for the first time and three new flavonoids, emarginin A (2), emarginin B (3), and emarginin C (4), together with 11 ...


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    authors: Tu PC,Liang YC,Huang GJ,Huang HC,Kao MC,Lu TL,Kuo YH

    更新日期:2020-03-01 00:00:00

  • Phenolic acids and their glycosides from the rhizomes of Cimicifuga dahurica.

    abstract::Phytochemical study on rhizomes of Cimicifuga dahurica resulted in the isolation of nine new neolignan and phenylpropanoid glycosides, cimicifugasides A-E (1, 2, 7-9), cimicifugamides B-D (3-5), shomaside G (6) along with four known compounds (10-13). Their structures were identified by extensive spectroscopic analyse...


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  • In vitro cytotoxicity of 11 Panamanian plants.

    abstract::Thirty-five crude extracts from 11 Panamanian plants, distributed in 10 genera and five families, were evaluated for their in vitro cytotoxicity. Four extracts exhibited an inhibition of cellular growth at IC(50) values lower than 25 microg/ml which was considered a significant activity. ...


    pub_type: 杂志文章


    authors: Calderón AI,Terreaux C,Gupta MP,Hostettmann K

    更新日期:2003-06-01 00:00:00

  • Antibacterial activity of Jatropha multifida roots.

    abstract::Hexane, ethyl acetate, chloroform and methanol successive extracts of Jatropha multifida yellow rootbark, red rootbark and rootwood effectively inhibited the growth of B. subtilis and S. aureus at concentration of 200 microg/disk. ...


    pub_type: 杂志文章


    authors: Aiyelaagbe OO

    更新日期:2001-06-01 00:00:00

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    authors: Radulović N,Misić M,Aleksić J,Doković D,Palić R,Stojanović G

    更新日期:2007-12-01 00:00:00

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    pub_type: 杂志文章


    authors: Jo JH,Kim JH,Lee HS,Jeong GS,Lee JM,Lee S

    更新日期:2017-07-01 00:00:00

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    pub_type: 杂志文章


    authors: Mitaine-Offer AC,Sauvain M,Petermann C,Zèches-Hanrot M

    更新日期:2001-11-01 00:00:00

  • Flavonoids and stilbenoids from Derris eriocarpa.

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    pub_type: 杂志文章


    authors: Zhang HX,Lunga PK,Li ZJ,Dai Q,Du ZZ

    更新日期:2014-06-01 00:00:00

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    pub_type: 杂志文章


    authors: Paul RK,Jabbar A,Rashid MA

    更新日期:2000-12-01 00:00:00

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    pub_type: 杂志文章


    authors: Xiang L,Wang Y,Yi X,He X

    更新日期:2019-09-01 00:00:00

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    pub_type: 杂志文章


    authors: Abdelgaleil SA,Iwagawa T,Doe M,Nakatani M

    更新日期:2004-09-01 00:00:00

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    pub_type: 杂志文章


    authors: Han S,Liu Y,Hou Z,Sun X,Yao G,Gao P,Li L,Song S

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    pub_type: 杂志文章


    authors: Hou Y,Wang M,Sun C,Peng C,Zhang Y,Li X

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    pub_type: 杂志文章


    authors: Bercion S,Couppe de K Martin MA,Baltaze JP,Bourgeois P

    更新日期:2005-12-01 00:00:00