Abstract：
:Two new isocoumarins (1 and 2), a new alkaloid (3), and a known N-acetyldopamine dimer (4) were isolated from the ethyl acetate extract of Chinese insect medicine Eupolyphaga sinensis. Their structures were elucidated on the basis of detailed spectroscopic investigations, such as 1D- and 2D NMR spectroscopy, as well as by means of HR-MS. The structure of 1 was firmly confirmed by X-ray crystallography, and the absolute configuration was revealed by experimental and computational optical rotation analyses. Cytotoxicities of 1-4 were measured in vitro against 10 selected cancer cell lines.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Jiang HL,Luo XH,Wang XZ,Yang JL,Yao XJ,Crews P,Valeriote FA,Wu QXdoi
10.1016/j.fitote.2012.06.005subject
Has Abstractpub_date
2012-10-01 00:00:00pages
1275-80issue
7eissn
0367-326Xissn
1873-6971pii
S0367-326X(12)00173-6journal_volume
83pub_type
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