当前位置： SCI文献检索 > FITOTERAPIA期刊下所有文献 > Beneficial effects of asiaticoside on cognitive deficits in senescence-accelerated mice.

Beneficial effects of asiaticoside on cognitive deficits in senescence-accelerated mice.

Abstract：

:The effect of asiaticoside isolated from Hydrocotyle sibthorpioides (AHS) on the promotion of cognition in senescence-accelerated mice (SAMP) was evaluated. Six-month old male SAMP8 mice were orally administered 20, 40 or 80 mg/kg AHS daily for three months. SAMR1 mice were used as a "normal aging" control. The results showed that treatment with AHS significantly improved learning and memory abilities in behavioral tests. AHS-treated mice showed higher antioxidant enzyme activity and lower lipid oxidation in serum compared with untreated SAMP8 mice. Mechanistically, studies showed that AHS markedly reduced the content and deposition of β-amyloid peptide (Aβ) by inhibiting the expression of mRNA for amyloid protein precursor, β-site amyloid cleaving enzyme-1 and cathepsin B and promoting the expression of mRNA for neprilysin and insulin degrading enzyme. In addition, AHS significantly increased the expression of plasticity-related proteins including postsynaptic density-95, phosphor-N-methyl-D-aspartate receptor 1, phospho-calcium-calmodulin dependent kinase II, phospho-protein kinase A Catalyticβ subunit, protein kinase Cγ subunit, phospho-CREB and brain derived neurotrophic factor. Furthermore, AHS increased the levels of acetylcholine (Ach), but decreased cholinesterase (AchE) activity. These results demonstrated that AHS administration may prevent spatial learning and memory decline by scavenging free radicals, up-regulating the activity of antioxidant enzymes, decreasing the level of Aβ, ameliorating dysfunction in synaptic plasticity, and reversing abnormal changes in Ach level and AchE activity. Thus, AHS should be developed as a new drug to prevent age-related cognitive deficits.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Lin X,Huang R,Zhang S,Wei L,Zhuo L,Wu X,Tang A,Huang Q

doi

10.1016/j.fitote.2013.03.023

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

69-77

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(13)00080-4

journal_volume

87

pub_type

杂志文章

相关文献

FITOTERAPIA文献大全
  • Identification of diterpene alkaloids from Aconitum napellus subsp. firmum and GIRK channel activities of some Aconitum alkaloids.

    abstract：:Diterpene alkaloids neoline (1), napelline (2), isotalatizidine (3), karakoline (4), senbusine A (5), senbusine C (6), aconitine (7) and taurenine (8) were identified from Aconitum napellus L. subsp. firmum, four (2-4, 6) of which are reported for the first time from this plant. The structures were determined by means...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2013.07.010

    authors： Kiss T,Orvos P,Bánsághi S,Forgo P,Jedlinszki N,Tálosi L,Hohmann J,Csupor D

    更新日期：2013-10-01 00:00:00

  • Effect of alcoholic extract of Ayurvedic herb Tinospora cordifolia on the proliferation and myeloid differentiation of bone marrow precursor cells in a tumor-bearing host.

    abstract：:The present study investigates the effect of in vivo administration of alcoholic extract of Tinospora cordifolia whole plant (ALTC) on the proliferation and myeloid differentiation of bone marrow hematopoietic precursor cells in mice bearing a transplantable T cell lymphoma of spontaneous origin designated as Dalton's...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2005.05.002

    authors： Singh SM,Singh N,Shrivastava P

    更新日期：2006-01-01 00:00:00

  • Clerodane-type diterpenoids from tuberous roots of Tinospora sagittata (Oliv.) Gagnep.

    abstract：:Three new clerodane type diterpenoids (2-4), together with one known analogues (1), were isolated from the tuberous roots of Tinospora sagittata (Oliv.) Gagnep. Compound 3 is an unusual clerodane diterpenoid with the carbonyl functionality at C-3, which represents the first example from this diterpenoid compounds clas...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2016.02.012

    authors： Zhang G,Ma H,Hu S,Xu H,Yang B,Yang Q,Xue Y,Cheng L,Jiang J,Zhang J,Wang F,Zhang Y

    更新日期：2016-04-01 00:00:00

  • Five rare C32 sesquiterpene lactone dimers with anti-inflammation activity from Vladimiria souliei.

    abstract：:Five rare sesquiterpene lactone dimers, vlasouliolides E-I, were isolated from Vladimiria souliei. Their chemical structures were elucidated by spectroscopic analysis. Furthermore, 2 and 4 were unambiguously confirmed by Cu-Kα X-ray crystallographic analysis. Compounds 1, 2, 4 and 5 exhibited significant anti-inflamma...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2018.01.002

    authors： Wu ZL,Wang JX,Chen LP,Dong HY,Li HL,Zhang WD

    更新日期：2018-03-01 00:00:00

  • New cycloartane triterpenes from bioactive extract of propolis from Pitcairn Island.

    abstract：:Dichloromethane extract of propolis (DCME) originating from Pitcairn Island demonstrated potent cytotoxicity against triple-negative MDA-MB-231 human breast carcinoma cells. The results from MTT assay showed that DCME inhibits the growth of the cancer cells in a dose- and time-dependent manner and upon the cell growth...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2018.05.024

    authors： Georgieva K,Trusheva B,Uzunova V,Stoyanova T,Valcheva V,Popova M,Tzoneva R,Bankova V

    更新日期：2018-07-01 00:00:00

  • Xanthones from the twigs of Garcinia oblongifolia and their antidiabetic activity.

    abstract：:Three new xanthones, oblongixanthone F-H (1-3), along with eight known xanthones (4-11), were isolated from an EtOAc extract of the twigs of Garcinia oblongifolia. Their structures were elucidated by spectroscopic analysis including 1D- and 2D-NMR spectroscopy and mass spectrometry. The antidiabetic effects of all iso...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2017.03.003

    authors： Trinh BT,Quach TT,Bui DN,Staerk D,Nguyen LD,Jäger AK

    更新日期：2017-04-01 00:00:00

  • Trypsin inhibitory activity of Lawsonia inermis.

    abstract：:The ethanolic extract of Lawsonia inermis leaves and lawsone tested for trypsin inhibitory activity showed an IC(50) value of 64.87 and 48.6 microg/ml, respectively. ...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/s0367-326x(02)00214-9

    authors： Yogisha S,Samiulla DS,Prashanth D,Padmaja R,Amit A

    更新日期：2002-12-01 00:00:00

  • Antimicrobial activity of Securinega leucopyrus.

    abstract：:Extracts of the leaves of Securinega leucopyrus exhibited a broad spectrum of antimicrobial activity. ...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/s0367-326x(01)00341-0

    authors： Bakshu LM,Jeevan Ram A,Venkata Raju R

    更新日期：2001-12-01 00:00:00

  • Essential oil of Lindera neesiana fruit: chemical analysis and its potential use in topical applications.

    abstract：:The composition of the essential oil of Lindera neesiana Kurz fruit was examined by GC-MS, (1)H, (13)C and bidimensional NMR techniques (HMQC, HMBC, COSY, TOCSY). Forty compounds were identified, representing approximately 86% of the oil: Z-citral (15.08%), E-citral (11.89%), eucalyptol (8.75%), citronellal (6.72%), a...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2009.06.017

    authors： Comai S,Dall'Acqua S,Grillo A,Castagliuolo I,Gurung K,Innocenti G

    更新日期：2010-01-01 00:00:00

  • Anticoagulant flavonoid oligomers from the rhizomes of Alpinia platychilus.

    abstract：:Two pairs of enantiomers of flavonoid oligomers (1a and 1b, 2a and 2b) along with one known chalcone (3) were isolated from the rhizomes of Alpinia platychilus. Their structures were elucidated on the basis of spectroscopic data (MS and 1D/2D NMR). The absolute configurations of the flavonoid oligomers were establishe...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2015.09.010

    authors： Shen CP,Luo JG,Yang MH,Kong LY

    更新日期：2015-10-01 00:00:00

  • Ursene type nortriterpene from Debregeasia salicifolia.

    abstract：:A new triterpene, 3beta-19alpha-dihydroxy-30-norurs-12-ene (1), has been isolated from the methanolic extract of Debregeasia salicifolia stems. Its structure has been elucidated with the help of one- and two-dimensional NMR and NOE studies. Lupeol, beta-sitosterol, stigmasterol and oleanolic acid are also reported for...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/s0367-326x(00)00338-5

    authors： Akbar E,Riaz M,Malik A

    更新日期：2001-05-01 00:00:00

  • Cytotoxic taraxerane triterpenoids from Saussurea graminea.

    abstract：:Four new taraxerane triterpenoids, 1β,3β-dihydroxy-11α,12α-oxidotaraxerane (1), 28-hydroxy-11α,12α-oxidotaraxerane-3-one (2), 3β-hydroxy-11α,12α-oxidotaraxerane-28-al (3), and 3-O-acetyl-11α,12α-oxidotaraxerane-28-al (4), together with three known compounds 3β-hydroxy-11α,12α-oxidotaraxerane (5), 3β,28-dihydroxy-11α,1...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2011.09.009

    authors： Hu J,Shi X,Chen J,Huang H,Zhao C

    更新日期：2012-01-01 00:00:00

  • Sesquiterpenoids from the seeds of Sarcandra glabra and the potential anti-inflammatory effects.

    abstract：:Five new sesquiterpenoids, including two linderanes (1-2) and three eudesmanes (3-5) were isolated from the seeds of Sarcandra glabra. Their structures and relative configurations were established by spectroscopic data analysis. 1 was a rare linderane derivative having an 18-membered triester ring which is a common ch...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2016.03.020

    authors： Yaermaimaiti S,Wang P,Luo J,Li RJ,Kong LY

    更新日期：2016-06-01 00:00:00

  • Atranones from Stachybotrys chartarum and their antitumor activities in MG-63 human osteosarcoma cells.

    abstract：:Two new atranones T and U (1 and 2), and three known analogues atranone B (3), atranone Q (4), and stachatranone C (5) were isolated from the toxigenic fungus Stachybotrys chartarum. Their structures and absolute configurations were elucidated by spectroscopic data and calculated ECD analyses. The cytotoxicities of al...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2020.104727

    authors： Qin YD,Fang FM,Zhou JJ,Wang RB,Xu SX,Li LH,Zhang HL

    更新日期：2020-10-01 00:00:00

  • Pharmacological studies in an herbal drug combination of St. John's Wort (Hypericum perforatum) and passion flower (Passiflora incarnata): in vitro and in vivo evidence of synergy between Hypericum and Passiflora in antidepressant pharmacological models.

    abstract：:Extracts of Hypericum, Passiflora and Valeriana are used for the treatment of mild depression and anxiety. We were interested whether a combination of Hypericum and Passiflora exerts comparable effects to Hypericum alone. We used two well-established models for investigating extracts for their anti-depressant activity...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2010.12.006

    authors： Fiebich BL,Knörle R,Appel K,Kammler T,Weiss G

    更新日期：2011-04-01 00:00:00

  • Cinchonicine-derived alkaloids from the bark of the Peruvian Ladenbergia oblongifolia.

    abstract：:The isolation of cinchonicine-derived alkaloids epicinchonicinol (1), cinchonidicinol (2) and a mixture of dihydrocinchonicinol and dihydrocinchonidicinol (3) from the dried bark of Ladenbergia oblongifolia, is reported along with (1)H and (13)C-NMR data. ...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/s0367-326x(01)00298-2

    authors： Okunade AL,Lewis WH,Elvin-Lewis MP,Casper SJ,Goldberg DE

    更新日期：2001-08-01 00:00:00

  • New α-glucosidase inhibitors with p-terphenyl skeleton from the mushroom Hydnellum concrescens.

    abstract：:The purpose of this study is to elucidate the bioactive components responsible for the the α-glucosidase inhibitory activity detected in the EtOAc extract of the mushroom Hydnellum concrescens. Two new p-terphenyl derivatives, concrescenins A (1) and B (2), in along with six known compounds thelephantins L (3), I (4),...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2014.07.019

    authors： Wang SM,Han JJ,Ma K,Jin T,Bao L,Pei YF,Liu HW

    更新日期：2014-10-01 00:00:00

  • Triglycerides from Urena lobata.

    abstract：:Two triglycerides, both bearing polyunsaturated fatty acid residues, were isolated from the hexane extract of Urena lobata. One of them is characterized by the presence of three different polyunsaturated fatty acids. Their structures were studied with spectral methods. ...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2006.03.010

    authors： Morelli CF,Cairoli P,Speranza G,Alamgir M,Rajia S

    更新日期：2006-06-01 00:00:00

  • Effects of isopulegol on pentylenetetrazol-induced convulsions in mice: possible involvement of GABAergic system and antioxidant activity.

    abstract：:The present study investigated the effects of isopulegol, a monoterpene alcohol, in PTZ-induced convulsions and verified possible involved mechanisms. Saline, isopulegol or diazepam were intraperitonealy injected 30 min before PTZ. The latency for development of convulsions and mortality, as well as the mortality prot...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2009.06.011

    authors： Silva MI,Silva MA,de Aquino Neto MR,Moura BA,de Sousa HL,de Lavor EP,de Vasconcelos PF,Macêdo DS,de Sousa DP,Vasconcelos SM,de Sousa FC

    更新日期：2009-12-01 00:00:00

  • The potent anti-inflammatory agent escin does not increase corticosterone secretion and immune cell apoptosis in mice.

    abstract：:Escin exerts potent glucocorticoid-like anti-inflammatory effects. The aim of this study was to investigate whether the anti-inflammatory effect of escin is through the up-regulation of glucocorticoids and if escin induces pathological changes in immune organs. Mice were administrated with escin intravenously for 7 da...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2011.04.004

    authors： Zhang L,Wang H,Fan H,Wang T,Jiang N,Yu P,Fu F

    更新日期：2011-09-01 00:00:00

  • Ginsenoside rich fraction of Panax ginseng C.A. Meyer improve feeding behavior following radiation-induced pica in rats.

    abstract：:Panax ginseng is an indigenous medicinal herb and has traditionally been used among Asian population for relief of many human ailments. We investigated the prophylactic role of Korean P. ginseng extract (KG) against X-ray irradiation-induced emesis in an acute rat pica model. Rats were treated with KG (12.5, 25, 50 mg...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2012.04.008

    authors： Balaji Raghavendran HR,Rekha S,Cho HK,Jang SS,Son CG

    更新日期：2012-09-01 00:00:00

  • Estrogenic and anti-estrogenic activities of hispolon from Phellinus lonicerinus (Bond.) Bond. et sing.

    abstract：:Hispolon was the main antitumor active ingredient in Phellinus sensu lato species. In order to confirm the dual regulating estrogenic ingredient and obtain more effective natural estrogen replacement drugs, hispolon was separated from Phellinus lonicerinus (Bond.) Bond. et sing. Hispolon exhibited significant anti-pro...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2014.03.007

    authors： Wang J,Hu F,Luo Y,Luo H,Huang N,Cheng F,Deng Z,Deng W,Zou K

    更新日期：2014-06-01 00:00:00

  • Radical scavenging capacity of Agrimonia eupatoria and Agrimonia procera.

    abstract：:The antioxidant activity of Agrimonia eupatoria (Agrimony) and Agrimonia procera (Fragrant agrimony) extracts was assessed by measuring in DPPH radical scavenging and ABTS(+) radical decolourisation reaction systems. Radical scavenging capacity of agrimony extracts varied in a wide range (9.1-97.5% in DPPH reaction an...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2006.10.002

    authors： Venskutonis PR,Skemaite M,Ragazinskiene O

    更新日期：2007-02-01 00:00:00

  • A novel water-soluble alpha-(1-->4)-glucan from the root of Cudrania tricuspidata.

    abstract：:CTPS-01, a water-soluble polysaccharide, was obtained from the root of Cudrania tricuspidata and estimated to have an average molecular weight of 5.9 x 10(3) and to be composed of glucose residues, solely. It contains an average repeating unit of decasaccharide, having a backbone consisting of 1,4-linked alpha-D-gluco...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2007.03.007

    authors： Shi L,Fu YL,Chen KS

    更新日期：2007-06-01 00:00:00

  • Lignans from the rhizomes of Iris tectorum.

    abstract：:Chemical examination of the ethanol extract of rhizomes of Iris tectorum led to the isolation and characterization of three new lignans, (7R,7'R,8S,8'S)-5'-methoxy-neo-olivil (1a), (7S,7'S,8R,8'R) -5'-methoxy-neo-olivil (1b), (7S,7'R,8S,8'S)-neo-olivil (2a), (7R,7'S,8R,8'R)-neo-olivil (2b), (7R,7'R,8S,8'S,7''S,8''S)-t...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2015.11.020

    authors： Zhang CL,Wang Y,Liu YF,Liang D,Hao ZY,Luo H,Chen RY,Yu DQ

    更新日期：2016-01-01 00:00:00

  • Naphthofuranone derivatives and other constituents from Pachira aquatica with inhibitory activity on superoxide anion generation by neutrophils.

    abstract：:Two new naphthofuranone derivatives, 11-hydroxy-2-O-methylhibiscolactone A (1) and O-methylhibiscone D (2), have been isolated from the stems of Pachira aquatica, together with 18 known compounds (3-20). The structures of two new compounds were determined through spectroscopic and MS analyses. Among the isolated compo...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2016.12.008

    authors： Cheng LY,Liao HR,Chen LC,Wang SW,Kuo YH,Chung MI,Chen JJ

    更新日期：2017-03-01 00:00:00

  • Dicaffeoyl polyamine derivatives from bitter goji: Contribution to the bitter taste of fruit.

    abstract：:Although the bioactive compounds in goji have been thoroughly identified and quantified, little information is available on the bitter compounds in the berries, and no systematic works on the substances responsible for their bitterness have been performed. Herein, the substances contributing to the bitterness of berri...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2020.104543

    authors： Qian D,Chen J,Lai C,Kang L,Xiao S,Song J,Xie J,Huang L

    更新日期：2020-06-01 00:00:00

  • Degraded limonoids and quinoline alkaloids from Dictamnus angustifolius G. Don ex Sweet. and their anti-platelet aggregation activity.

    abstract：:A new degraded limonoid, named isodictamdiol A (1), two known degraded limonoids (2, 3) and a new nature product of quinoline alkaloid (4) along with five known quinoline alkaloids (5-9) were isolated from the root bark of Dictamnus angustifolius G. Don ex Sweet.. Certain useful NMR data were generalized to determine ...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2013.07.023

    authors： Sun JB,Qu W,Wang P,Wu FH,Wang LY,Liang JY

    更新日期：2013-10-01 00:00:00

  • Five new cycloartane triterpenoids from Beesia calthifolia.

    abstract：:Phytochemical study on rhizomes of Beesia calthifolia resulted in the isolation of five new (1-5) and three known (6-8) cycloartane triterpenoids possessing a hemiketal or ketal group at C-24 from the EtOAc fraction of 95% ethanol extract. Their structures were determined by spectroscopic and chemical methods, especia...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2015.04.017

    authors： Zheng DJ,Zhou J,Liu Q,Yao W,Zhang MZ,Shao BH,Mo JX,Zhou CX,Gan LS

    更新日期：2015-06-01 00:00:00

  • Flavonol glycosides from Aconitum vulparia.

    abstract：:The isolation of five flavonol glycosides (1-5) from the flowers of Aconitum vulparia is reported, together with the 1H- and 13C-NMR spectral data in CD(3)OD of compound 3 and 5. ...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/s0367-326x(03)00045-5

    authors： Fico G,Braca A,Morelli I,Tomè F

    更新日期：2003-06-01 00:00:00