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Pharmacological studies in an herbal drug combination of St. John's Wort (Hypericum perforatum) and passion flower (Passiflora incarnata): in vitro and in vivo evidence of synergy between Hypericum and Passiflora in antidepressant pharmacological models.

Abstract：

:Extracts of Hypericum, Passiflora and Valeriana are used for the treatment of mild depression and anxiety. We were interested whether a combination of Hypericum and Passiflora exerts comparable effects to Hypericum alone. We used two well-established models for investigating extracts for their anti-depressant activity, namely the effects on synaptic uptake of serotonin and the forced-swimming-test. We show here for the first time, that Passiflora significantly enhances the pharmacological potency of Hypericum in both models. Our data suggest that anti-depressive therapeutic effects of Hypericum are possible with lower doses, when it is combined with Passiflora, than with mono-preparations of Hypericum.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Fiebich BL,Knörle R,Appel K,Kammler T,Weiss G

doi

10.1016/j.fitote.2010.12.006

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

474-80

issue

3

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(10)00322-9

journal_volume

82

pub_type

杂志文章

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