Abstract：
:Six new triterpenoids, pseudolarins A-F (1-6), were isolated from the twigs of Pseudolarix amabilis, together with four known triterpenoids (7-10) and five known diterpenoids (11-15). Their structures were determined by extensive spectroscopic analysis, and the absolute configuration of 1 was assigned by single-crystal X-ray diffraction. Compound 1 is a 3,4:9,10-diseco-cycloartane triterpenoid possessing an unprecedented 5/5/7/6/5/6/5 ring system. Compounds 1, 5, 7, 9-11, and 13 showed inhibition against protein tyrosine phosphatase 1B (PTP1B) in vitro.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Lei C,Huang QH,Zhao T,Wang PP,Li JY,Li J,Hou AJdoi
10.1016/j.fitote.2019.104414subject
Has Abstractpub_date
2019-11-01 00:00:00pages
104414eissn
0367-326Xissn
1873-6971pii
S0367-326X(19)31988-4journal_volume
139pub_type
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