Abstract：
:Soluble proteins from the latex of Calotropis procera (LP) were investigated in vitro and in vivo for digestibility as the latex has previously been shown to produce considerable toxic effects on animals. The latex is also an important biologically active compound that displays antiinflammatory and antidiarrhea properties. The proteins were digested by the action of trypsin, pepsin or chemotrypsin as revealed by gel filtration and SDS-PAGE analysis. Furthermore, the full LP digestion was easily achieved by protease treatment. Rabbit polyclonal antibodies raised against LP failed to detect cross-reactive molecules in fecal material of experimental rats following 35 consecutive days of LP consumption in water. Similar patterns of electrophoresis were observed for the negligible amounts of protein observed in the fecal extracts of control and test animals. No death or toxic effects were observed among animals. Taken together these results suggest that harmful and toxic effects on animals of the latex from C. procera are present in its rubber and low molecular weight fractions rather than its protein content.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Ramos MV,Aguiar VC,da Silva Xavier AA,Lima MW,Bandeira GP,Etchells JP,Nogueira NA,Alencar NMdoi
10.1016/j.fitote.2006.02.010keywords:
subject
Has Abstractpub_date
2006-06-01 00:00:00pages
251-6issue
4eissn
0367-326Xissn
1873-6971pii
S0367-326X(06)00039-6journal_volume
77pub_type
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