Abstract:
:Cordia dichotoma f. (Boraginaceae) is a small deciduous tree from India. The bark of was used in the treatment of ulcerative colitis (UC) and colic pain traditionally hence present work was undertaken to identify the phytoconstituent responsible for this activity. Apigenin is isolated by column chromatography from methanol fraction of crude methanol extract of C. dichotoma bark. Structure of apigenin is established by various spectroscopic studies. Apigenin (5mg/kg, p.o.) showed significant healing and reduction in inflammatory enzymes when screened for UC. It can be concluded that apigenin from C. dichotoma bark may be responsible for the treatment of UC.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Ganjare AB,Nirmal SA,Patil ANdoi
10.1016/j.fitote.2011.06.008subject
Has Abstractpub_date
2011-10-01 00:00:00pages
1052-6issue
7eissn
0367-326Xissn
1873-6971pii
S0367-326X(11)00164-Xjournal_volume
82pub_type
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