Use of apigenin from Cordia dichotoma in the treatment of colitis.

Abstract:

:Cordia dichotoma f. (Boraginaceae) is a small deciduous tree from India. The bark of was used in the treatment of ulcerative colitis (UC) and colic pain traditionally hence present work was undertaken to identify the phytoconstituent responsible for this activity. Apigenin is isolated by column chromatography from methanol fraction of crude methanol extract of C. dichotoma bark. Structure of apigenin is established by various spectroscopic studies. Apigenin (5mg/kg, p.o.) showed significant healing and reduction in inflammatory enzymes when screened for UC. It can be concluded that apigenin from C. dichotoma bark may be responsible for the treatment of UC.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Ganjare AB,Nirmal SA,Patil AN

doi

10.1016/j.fitote.2011.06.008

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

1052-6

issue

7

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(11)00164-X

journal_volume

82

pub_type

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