Abstract:
:The furanocoumarin imperatorin has been reported to have hypotensive effect, and we have investigated its activity on myocardial hypertrophy. Imperatorin displayed similar chromatographic retention peak to verapamil in the model of cardiac muscle/cell membrane chromatography, and could reduce in a concentration-dependent way protein content and cell size of myocytes prestimulated with angiotensin II. The ratio of heart weight to body weight (mg/g) (4.13 ± 0.06 in SHRs, 3.77 ± 0.02 with imperatorin 25 mg kg(-1)d(-1) 16 17 ig, P<0.01) was significantly lower in the imperatorin-treated SHRs. Taken together, our observations show that imperatorin exerts anti-hypertrophic effect both in vitro and in vivo.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Zhang Y,Cao Y,Zhan Y,Duan H,He Ldoi
10.1016/j.fitote.2010.07.023subject
Has Abstractpub_date
2010-12-01 00:00:00pages
1188-95issue
8eissn
0367-326Xissn
1873-6971pii
S0367-326X(10)00200-5journal_volume
81pub_type
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