New alkaloidal metabolites from cultures of entomopathogenic fungus Cordyceps takaomontana NBRC 101754.

Abstract:

:Two new alkaloidal metabolites, cordytakaoamides A (1) and B (2), as well as, 2-[(2-hydroxyethyl) amino] benzoic acid (3) and 2E-decenamide (4), and three known compounds (5-7) were isolated from ethyl acetate and n-butanol soluble portions of the entomopathogenic fungus, Cordyceps takaomontana NBRC 101754. Compounds 3 and 4 were isolated here for first time from natural resources. The chemical structures were established depending upon spectroscopic techniques such as 1D, 2D NMR, and HRMS. The absolute configuration of 1 and 2 was elucidated via the total synthesis of 1 as well as the experimental circular dichroism. Compound 3 was confirmed by a signal crystal X-ray analysis.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Hama M,Elshamy AI,Yoneyama T,Kasai Y,Yamamoto H,Tanigawa K,Oshiro A,Noji M,Ban S,Imagawa H,Umeyama A

doi

10.1016/j.fitote.2019.104364

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

104364

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(19)31741-1

journal_volume

139

pub_type

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