5,6,7,3',4',5'-Hexamethoxyflavone from the Australian plant Eremophila debilis (Myoporaceae).

abstract：:Three new xanthones, cylindroxanthones A-C (1-3), were isolated from the stem bark of Garcinia cylindrocarpa. The structures were established on the basis of spectroscopic analysis. The molecular structure of 1 was unequivocally confirmed by single-crystal X-ray diffraction analysis. These three xanthones were evaluat...

journal_title：Fitoterapia

authors： Sukandar ER,Ersam T,Fatmawati S,Siripong P,Aree T,Tip-pyang S

更新日期：2016-01-01 00:00:00

abstract：:Five new steroids, colebrin A-E (1-5) were isolated from the aerial parts of Clerodendrum colebrookianum. The structures of the new compounds were elucidated on the basis of spectral evidence. ...

journal_title：Fitoterapia

authors： Yang H,Wang J,Hou AJ,Guo YP,Lin ZW,Sun HD

更新日期：2000-12-01 00:00:00

abstract：:Infusions of Picrolemma sprucei roots, stems and leaves are used in traditional medicine throughout the Amazon region from the Guianas to Brazil and Peru in the treatment of gastritis, intestinal helminths and malaria. As there are no studies describing its mode of action in providing a gastroprotective effect, we det...

journal_title：Fitoterapia

authors： Vieira SM,Silva RL,Lemos HP,Amorim RC,Silva EC,Reinach PS,Cunha FQ,Pohlit AM,Cunha TM

更新日期：2014-06-01 00:00:00

abstract：:The gastrointestinal activity of hydroalcoholic extract (HE) of Salvia officinalis was evaluated in a model of ethanol-induced gastric lesion. HE showed excellent activity, with ID(50) 84.0 (54.8-128.9) mg/kg. The acetic acid-induced ulcer and the total acidity of the gastric secretion were also reduced by HE, and, in...

journal_title：Fitoterapia

authors： Mayer B,Baggio CH,Freitas CS,dos Santos AC,Twardowschy A,Horst H,Pizzolatti MG,Micke GA,Heller M,dos Santos EP,Otuki MF,Marques MC

更新日期：2009-10-01 00:00:00

abstract：:Three novel xanthonolignoid C-glycosides, glomexanthones A-C, with a trans-dihydrobenzofuran on B ring and a 2-hydroxymethyl-5-hydroxyl-2-pentenoic acid moiety in the sugar chain were isolated from an ethanol extract of Polygala glomerata. Their structures and absolute configurations were characterized by extensive NM...

journal_title：Fitoterapia

authors： Li CJ,Yang JZ,Yu SS,Zhao CY,Peng Y,Wang XL,Zhang DM

更新日期：2014-03-01 00:00:00

abstract：:Aloe barbadensis Mill has been used as food and medicine for a long time. In order to investigate the chemical constituents of A. barbadensis and their inhibitory activities towards phosphodiesterase-4D (PDE4D), 70% methanol extract of the dried A. barbadensis powder was employed. Phytochemical investigation has led t...

journal_title：Fitoterapia

authors： Zhong J,Huang Y,Ding W,Wu X,Wan J,Luo H

更新日期：2013-12-01 00:00:00

abstract：:There is growing evidence that motherwort (Leonurus japonicus Houtt.), and Chinese patent medicines derived from motherwort, alleviate postpartum uterine subinvolution, as well as the effects on myocardial and cerebral ischemic injuries. We hypothesized that these beneficial effects of motherwort may be related to ang...

journal_title：Fitoterapia

authors： He YL,Shi JY,Peng C,Hu LJ,Liu J,Zhou QM,Guo L,Xiong L

更新日期：2018-07-01 00:00:00

abstract：:Four new C18-diterpenoid alkaloids, weisaconitines A-D (1-4), were isolated from Aconitum weixiense. Based on extensive UV, IR, MS, 1D and 2D NMR analyses, their structures were elucidated as 8-O-ethyldolaconine (1), 4-demethylgenicunine B (2), 14-oxoaconosine (3), and 8-O-ethylaconosine (4). The analgesic activity of...

journal_title：Fitoterapia

authors： Zhao DK,Ai HL,Zi SH,Zhang LM,Yang SC,Guo HC,Shen Y,Chen YP,Chen JJ

更新日期：2013-12-01 00:00:00

abstract：:The plants of genus Toona are well known for diverse limonoid secondary metabolites, while polyacetylenes are rarely found from Toona species. In this work, six new polyacetylenes toonasindiynes A-F (1-6) and six known analogues (7-12) were isolated from the root bark of Toona sinensis. Their structures and absolute c...

journal_title：Fitoterapia

authors： Xu WJ,Li JH,Zhou MM,Luo J,Jian KL,Tian XM,Xia YZ,Yang L,Luo J,Kong LY

更新日期：2020-10-01 00:00:00

abstract：:A series of new Lycopodium alkaloids, namely 1-epi-malycorin A (1), 1-epi-17S-hydroxymalycorin A (2), 6α-hydroxyphlegmariurine A (3), 2S,4R-dihydroxyfawcettimine (4), and 16-hydroxylycodine (5), together with 24 known ones, have been isolated from the club moss Phlegmariurus henryi. The structures of the new compounds...

journal_title：Fitoterapia

authors： Liu YC,Su J,Wu XD,Zhang ZJ,Fan M,Zhu QF,He J,Li XN,Peng LY,Cheng X,Zhao QS

更新日期：2016-12-01 00:00:00

abstract：:The methanolic extract and total alkaloids of the aerial parts of Glaucium oxylobum exhibited good activity against Microsporum gypseum, Microsporum canis, Trichophyton mentagrophytes and Epidermophyton floccosum. Four alkaloids, dicentrine, glaucine, protopine, and alpha-allocryptopine, were identified as the compoun...

journal_title：Fitoterapia

authors： Morteza-Semnani K,Amin G,Shidfar MR,Hadizadeh H,Shafiee A

更新日期：2003-07-01 00:00:00

abstract：:Nineteen secolignans (1-19), including five new ones (1-5), were isolated from the whole plant of Peperomia dindygulensis. Their structures including stereochemistry were determined by spectroscopic methods, in particular NMR and electronic CD (ECD) analysis. All the isolates were evaluated for their inhibitory activi...

journal_title：Fitoterapia

authors： Sun RF,Zhu CC,Yang Y,Yu NJ

更新日期：2017-10-01 00:00:00

abstract：:Chemical examination of the ethanol extract of rhizomes of Iris tectorum led to the isolation and characterization of three new lignans, (7R,7'R,8S,8'S)-5'-methoxy-neo-olivil (1a), (7S,7'S,8R,8'R) -5'-methoxy-neo-olivil (1b), (7S,7'R,8S,8'S)-neo-olivil (2a), (7R,7'S,8R,8'R)-neo-olivil (2b), (7R,7'R,8S,8'S,7''S,8''S)-t...

journal_title：Fitoterapia

authors： Zhang CL,Wang Y,Liu YF,Liang D,Hao ZY,Luo H,Chen RY,Yu DQ

更新日期：2016-01-01 00:00:00

abstract：:Two new neo-clerodane diterpenoids have been isolated from the whole plant of Scutellaria barbata D. Don, and their structures were established by detailed spectral analyses as scutehenanine H (1) and 6-(2,3-epoxy-2-isopropyl-n-propoxyl)barbatin C (2). In vitro, the isolated two new compounds showed significant cytoto...

journal_title：Fitoterapia

authors： Dai SJ,Qu GW,Yu QY,Zhang DW,Li GS

更新日期：2010-10-01 00:00:00

abstract：:A series of novel myricetin derivatives containing benzimidazole skeleton were constructed. The structure of compound 4g was further corroborated via X-ray single crystal diffractometer. The antimicrobial bioassays showed that all compounds exhibited potent inhibitory activities against Xanthomonas axonopodis pv. Citr...

journal_title：Fitoterapia

authors： Chen M,Tang X,Liu T,Peng F,Zhou Q,Luo H,He M,Xue W

更新日期：2020-12-11 00:00:00

abstract：:Five vibralactone derivatives containing γ, δ, ε-lactone cores, namely vibralactones X (1), Y (2), and Z1-Z3 (3-5), together with the known vibralactone, have been isolated from cultures of the basidiomycete Boreostereum vibrans. Compounds 3-5 possessed a novel bis-γ-lactone group which was found in vibralactone deriv...

journal_title：Fitoterapia

authors： Duan KT,Li ZH,Yu X,Yuan QX,Wang WX,Li J,Chen HP,Feng T,Liu JK

更新日期：2018-07-01 00:00:00

abstract：:Flos Chrysanthemi (the flower of Chrysanthemum morifolium Ramat.) is widely used in China as a food and traditional Chinese medicine for many diseases. Luteolin and apigenin are two main bioactive components in Flos Chrysanthemi, and chrysoeriol and diosmetin are two methylated metabolites of luteolin in vivo by cathe...

journal_title：Fitoterapia

authors： Chen Z,Kong S,Song F,Li L,Jiang H

更新日期：2012-12-01 00:00:00

abstract：:alpha(2)beta(1) and alpha(IIb)beta(3) integrins, that support platelet adhesion to collagen and fibrinogen, respectively, share common signaling molecules. The effect of quercetin on platelet static adhesion to collagen and fibrinogen was assessed and correlated with its kinase inhibitory activity. Quercetin strongly ...

journal_title：Fitoterapia

authors： Navarro-Núñez L,Lozano ML,Martínez C,Vicente V,Rivera J

更新日期：2010-03-01 00:00:00

abstract：:Two spiro paclitaxel-mimics consisting only of an oxetane D-ring and a C-13 side chain were designed and synthesized on the basis of analysis of structure-activity relationships (SAR) of paclitaxel. In vitro microtubule-stabilizing and antiproliferative assays indicated a moderate weaker activity of the mimics than pa...

journal_title：Fitoterapia

authors： Chen XX,Gao F,Wang Q,Huang X,Wang D

更新日期：2014-01-01 00:00:00

abstract：:Phytochemical study on rhizomes of Cimicifuga dahurica resulted in the isolation of nine new neolignan and phenylpropanoid glycosides, cimicifugasides A-E (1, 2, 7-9), cimicifugamides B-D (3-5), shomaside G (6) along with four known compounds (10-13). Their structures were identified by extensive spectroscopic analyse...

journal_title：Fitoterapia

authors： Lu Q,Zhang WY,Pan DB,Shi DF,Pang QQ,Li HB,Yao XJ,Yao ZH,Yu Y,Yao XS

更新日期：2019-04-01 00:00:00

abstract：:Two new dimeric diarylheptanoids, named Alpinin C (1) and D (2), a new natural product of diarylheptanoid (3) along with three known diarylheptanoids (4-6) were isolated from the rhizomes of Alpinia officinarum Hance. Their structures were elucidated based on extensive spectroscopic analyses (1D and 2D NMR, HRTOFMS, I...

journal_title：Fitoterapia

authors： Liu D,Liu YW,Guan FQ,Liang JY

更新日期：2014-07-01 00:00:00

abstract：:Ailanthone (AIL) has many biological activities including antimalarial, antiviral and anticancer. Our previous study also found that AIL targets p23 against castration-resistant prostate cancer. In this report, the preclinical safety of AIL was evaluated by acute toxicity, subacute toxicity and toxicokinetics in mice....

journal_title：Fitoterapia

authors： Tang S,Ma X,Lu J,Zhang Y,Liu M,Wang X

更新日期：2019-07-01 00:00:00

abstract：:Largely widespread in tropical countries, Ocimum gratissimum has been claimed for many uses in folk medicine. Recent research on its essential oils showed five chemotypes. An Indian chemotype, with a high level of ethyl cinnamate, presents, in vitro, an interesting spectrum of antifungal properties. ...

journal_title：Fitoterapia

authors： Dubey NK,Tiwari TN,Mandin D,Andriamboavonjy H,Chaumont JP

更新日期：2000-09-01 00:00:00

abstract：:Two new alkaloids were isolated from the bark of Sarcomelicope megistophylla. Cyclomegistine B (1), a new quinolone alkaloid, that possesses a rare cyclobuta[b]quinoline ring system and sarcomejine B (2) which is a quinolone alkaloid with an unusual side chain. The structure of both compounds was elucidated on the bas...

journal_title：Fitoterapia

authors： Mitaku S,Fokialakis N,Magiatis P,Tillequin F

更新日期：2007-02-01 00:00:00

abstract：:Three new xanthones, named kaennacowanols A-C (1-3), along with nineteen known xanthones were isolated from the roots of Garcinia cowa Roxb. Their structures were determined by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicity against KB and HeLa cell lines. Compounds 17 and 22 showe...

journal_title：Fitoterapia

authors： Kaennakam S,Siripong P,Tip-Pyang S

更新日期：2015-04-01 00:00:00

abstract：:Chiratone (1), a rare new chiratane type triterpenoid, together with five known triterpenoids were isolated from the rhizomes of Drynaria fortunei (Kunze) J. Sm. The structure was characterized as 20β-hydroxychiratan-22-one on the basis of extensive 1D and 2D NMR, and MS spectroscopic analyses, and was further confirm...

journal_title：Fitoterapia

authors： Liang YH,Wang W,Yu SW,Ye M,He XH,Gong NB,Lu Y,Khan IA,Guo DA

更新日期：2010-12-01 00:00:00

abstract：:Four new sesquiterpenoids, phellinignins A-D (1-4), together with four known ones (5-8), were isolated from cultures of the fungus Phellinus igniarius. The structures were established by extensive spectroscopic methods including MS, NMR, and the single crystal X-ray diffraction. Compounds 1-3 and 5-8 are tremulane ses...

journal_title：Fitoterapia

authors： Wu PF,Ding R,Tan R,Liu J,Hu EM,Li CY,Liang GY,Yi P

更新日期：2020-01-01 00:00:00

abstract：:Calcium-activated chloride channels (CaCCs) as a kind of widely expressed ion channels play crucial roles in a variety of physiological regulation. TMEM16A has been identified as the molecular basis of CaCCs in numerous cell types and is considered a new drug target for many diseases. Regulating the function of TMEM16...

journal_title：Fitoterapia

authors： Zhu X,Zhang W,Jin L,Zhang G,Yang H,Yu B

更新日期：2020-11-01 00:00:00

abstract：:7-O-methylvariecolortide A (1), variecolortide B (2), and variecolortide C (3), the rare variecolortides existing in racemic manner, were isolated from an endolichenic fungal strain Eurotium sp. (No. 17-11-8-1). With the chiral HPLC technology, (-)-(S)-7-O-methylvariecolortide A (1a), (+)-(R)-7-O-methylvariecolortide ...

journal_title：Fitoterapia

authors： Chen GD,Bao YR,Huang YF,Hu D,Li XX,Guo LD,Li J,Yao XS,Gao H

更新日期：2014-01-01 00:00:00

abstract：:A new sesquiterpene coumarin with a novel sesquiterpene carbon framework, Sinkiangenorin D, and ten known sesquiterpene coumarins were isolated from the seeds of Ferula sinkiangensis. The structures of these compounds, including the relative stereochemistry, were elucidated on the basis of spectroscopic data. All of t...

journal_title：Fitoterapia

authors： Li G,Li X,Cao L,Zhang L,Shen L,Zhu J,Wang J,Si J

更新日期：2015-06-01 00:00:00