Abstract:
:alpha(2)beta(1) and alpha(IIb)beta(3) integrins, that support platelet adhesion to collagen and fibrinogen, respectively, share common signaling molecules. The effect of quercetin on platelet static adhesion to collagen and fibrinogen was assessed and correlated with its kinase inhibitory activity. Quercetin strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. Quercetin or the combined use of adenosine diphosphate and thromboxane A(2) inhibitors abrogated platelet spreading on these surfaces to a similar extent. We suggest that the inhibitory effect of quercetin on platelet kinases blocks early signaling events preventing a complete platelet spreading.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Navarro-Núñez L,Lozano ML,Martínez C,Vicente V,Rivera Jdoi
10.1016/j.fitote.2009.08.006subject
Has Abstractpub_date
2010-03-01 00:00:00pages
75-80issue
2eissn
0367-326Xissn
1873-6971pii
S0367-326X(09)00180-4journal_volume
81pub_type
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