Abstract:
:Bergamot juice produces hypolipemic activity in rats though the mechanism remains unclear. Here we investigated on the effect of bergamot extract (BPF) in diet-induced hyperlipemia in Wistar rats and in 237 patients suffering from hyperlipemia either associated or not with hyperglycaemia. BPF, given orally for 30 days to both rats and patients, reduces total and LDL cholesterol levels (an effect accompanied by elevation of cHDL), triglyceride levels and by a significant decrease in blood glucose. Moreover, BPF inhibited HMG-CoA reductase activity and enhanced reactive vasodilation thus representing an efficient phytotherapeutic approach in combating hyperlipemic and hyperglycaemic disorders.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Mollace V,Sacco I,Janda E,Malara C,Ventrice D,Colica C,Visalli V,Muscoli S,Ragusa S,Muscoli C,Rotiroti D,Romeo Fdoi
10.1016/j.fitote.2010.10.014subject
Has Abstractpub_date
2011-04-01 00:00:00pages
309-16issue
3eissn
0367-326Xissn
1873-6971pii
S0367-326X(10)00277-7journal_volume
82pub_type
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