A new coumestan with immunosuppressive activities from Flemingia philippinensis.

Abstract:

:A new coumestan, 1,3,9-trihydroxy-8-methoxycoumestan, named flemicoumestan A 1 together with nine isoflavone-related compounds were isolated from the ethyl acetate extract of the roots of Flemingia philippinensis. Their structures were elucidated and confirmed by spectroscopic methods and literature data. Compounds 3 and 4 showed strong lymphocyte proliferation inhibitory activity with an IC(50) value of 1.04-2.76 μM, and the low cytotoxicity with the CC(50) value of 71.01 and 56.36 μM, respectively.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Li L,Deng X,Zhang L,Shu P,Qin M

doi

10.1016/j.fitote.2011.01.019

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

615-9

issue

4

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(11)00040-2

journal_volume

82

pub_type

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