Abstract：
:Hydroxysafflor yellow A (HSYA) is an active ingredient obtained from the flower of Carthamus tinctorius L. The present study investigated the effects of HSYA on lipopolysaccharide (LPS)-induced inflammatory signal transduction in human alveolar epithelial A549 cells. A549 cells stimulated with LPS were incubated with three doses of HSYA (1, 4 and 16μmol/L). HSYA suppressed the expression of TLR-4, Myd88, ICAM-1, TNFα, IL-1β and IL-6 at the mRNA and protein level, and inhibited the adhesion of leukocytes to A549 cells. HSYA treatment also decreased NF-κB p65 nuclear translocation and inhibited the phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK). These findings suggest that HSYA effectively inhibits LPS-induced inflammatory signal transduction in A549 cells.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Song L,Zhu Y,Jin M,Zang Bdoi
10.1016/j.fitote.2012.11.004subject
Has Abstractpub_date
2013-01-01 00:00:00pages
107-14eissn
0367-326Xissn
1873-6971pii
S0367-326X(12)00297-3journal_volume
84pub_type
杂志文章相关文献
FITOTERAPIA文献大全abstract：:1,2-Dihydroxyanthraquinone (1) was isolated from the seed of Cassia obtusifolia through bioassay-guided fractionation. 1,2-Dihydroxyanthraquinone strongly inhibited the growth of Clostridium perfringens and Escherichia coli. Structure-activity relationship revealed that 1,4-dihydroxyanthraquinone (2) and 1,8-dihydroxy...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2004.03.012
更新日期：2004-07-01 00:00:00
abstract：:The Goodeniaceae family contributes some of the more spectacular wildflowers found on the Australian continent. The bright and vibrant colours that characterise members of the family has attracted much horticultural interest. A number of species have traditionally been used for medicinal purposes by indigenous communi...
journal_title：Fitoterapia
pub_type： 杂志文章,评审
doi：10.1016/j.fitote.2004.01.018
更新日期：2004-07-01 00:00:00
abstract：:Investigation of the fruits of Khaya senegalensis resulted in the isolation of three new mexicanolide limonoids containing a rare conjugated diene lactone system named seneganolide A (1), 2-hydroxyseneganolide A (2) and 2-acetoxyseneganolide A (3). Two known limonoids, 3-deacetyl-7-deacetoxy-7-oxokhivorin (4) and meth...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2004.06.001
更新日期：2004-09-01 00:00:00
abstract：:The cardioprotective effect of Prunella vulgaris ethylacetate fraction (PVEF) and its constituent rosmarinic acid (RA) was evaluated on isolated rat cardiomyocytes subjected to doxorubicin-induced oxidative stress. The cytoprotectivities of PVEF and RA were concentration-dependent in the range of 0.005 to 0.05 mg/ml a...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2005.04.019
更新日期：2005-09-01 00:00:00
abstract：:Two new compounds, 6-oxo-20-hydroxy-20-epi-tingenol (1) and 2R*,3R*,5S*-trihydroxy-6R*-nonadecyltetrahydropyran-4-one (2), were isolated from the pericarp of Glyptopetalum sclerocarpum along with other 10 constituents. ...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2004.04.012
更新日期：2004-09-01 00:00:00
abstract：:The objective of this study was to evaluate potential hepatoprotective capabilities of quercetin in relation to its modulation of the HO-1 and NOS-2 activities in an experimental model of fulminant liver failure. Liver insult was induced by in vivo administration of D-galactosamine (d-GalN, 400 mg/kg, i.p.) and lipopo...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2013.03.016
更新日期：2013-06-01 00:00:00
abstract：:This manuscript reports on the first CE-method suitable for analyzing twelve pharmacologically relevant compounds (flavonoids, caffeic acids and leontopodic acid) in the aerial parts of Leontopodium alpinum. By using a 60mM borax buffer containing 25mM SDS and 35% acetonitrile the analytes could be well resolved in 25...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2012.09.023
更新日期：2012-12-01 00:00:00
abstract：:Investigation of the bioactive secondary metabolites of the marine actinomycetes Rubrobacter radiotolerans led to the isolation and characterization of two naturally rare dimeric indole derivatives (1 and 2). The structures of these new compounds were elucidated by spectroscopic data interpretation, and the absolute c...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2015.01.014
更新日期：2015-04-01 00:00:00
abstract：:A new sesquiterpene coumarin with a novel sesquiterpene carbon framework, Sinkiangenorin D, and ten known sesquiterpene coumarins were isolated from the seeds of Ferula sinkiangensis. The structures of these compounds, including the relative stereochemistry, were elucidated on the basis of spectroscopic data. All of t...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2015.03.022
更新日期：2015-06-01 00:00:00
abstract：:Euphorbia aellenii Rech. f. (Euphorbiaceae) afforded a cytotoxic chloroform fraction from which two new esters of 6(17)-epoxylathyrol were identified (1 and 2). The structure of these compounds was elucidated by spectroscopic methods. ...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2010.05.017
更新日期：2010-10-01 00:00:00
abstract：:Different lines of experimental evidence indicate that treatment with extracts from and derivatives of Phaseolus vulgaris reduces intake of food, including highly palatable foods and beverages, in rats. The present study was designed to extend to mice these lines of evidence. To this end, CD1 mice were treated acutely...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2012.12.015
更新日期：2013-03-01 00:00:00
abstract：:The present study was aimed to investigate the possible interaction of the standardized extract of Acorus calamus (AC) with Cytochrome P450 enzyme, quantitative determination of the α-asarone in the AC rhizome was performed by RP-HPLC method. In vitro interaction of the plant extract was evaluated by CYP450-carbon mon...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2010.11.009
更新日期：2011-04-01 00:00:00
abstract：:Five pyrrolizidine alkaloids have been isolated from Heliotropium subulatum and tested for their antimicrobial activity. ...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/s0367-326x(02)00016-3
更新日期：2002-04-01 00:00:00
abstract：:The effect of asiaticoside isolated from Hydrocotyle sibthorpioides (AHS) on the promotion of cognition in senescence-accelerated mice (SAMP) was evaluated. Six-month old male SAMP8 mice were orally administered 20, 40 or 80 mg/kg AHS daily for three months. SAMR1 mice were used as a "normal aging" control. The result...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2013.03.023
更新日期：2013-06-01 00:00:00
abstract：:Five pairs of new 2-oxoindole alkaloids, (±)-peganumalines A-E (1-5), and a new indole alkaloid, peganumaline F (6), along with two known analogues, were isolated from the seeds of Peganum harmala. Their structures and absolute configurations were elucidated through spectroscopic analyses and quantum chemistry calcula...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2018.01.008
更新日期：2018-03-01 00:00:00
abstract：:Supercritical CO(2) fluid extraction (SFE-CO(2)) was used to extract the sapogenins after acid hydrolysis from Smilax china tubers. The influence of extraction variables, such as modifier, pressure, temperature and extraction time, were studied. SFE-CO(2) was found to produce higher yield than conventional solvent ext...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2004.06.011
更新日期：2004-12-01 00:00:00
abstract：:Calcium-activated chloride channels (CaCCs) as a kind of widely expressed ion channels play crucial roles in a variety of physiological regulation. TMEM16A has been identified as the molecular basis of CaCCs in numerous cell types and is considered a new drug target for many diseases. Regulating the function of TMEM16...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2020.104736
更新日期：2020-11-01 00:00:00
abstract：:One new resveratrol analogue, 1-(3',4',5'-trimethoxyphenyl)-2-methoxy-2-(4″-methoxyphenyl)-ethane-1-ol (1), and two new prenylisoflavones, 4'-hydroxy-5,7-dimethoxy-6-(3-methyl-2-butenyl)-isoflavone (2), and derrubon 5-methyl ether (3), together with 17 known compounds including one new natural product, 5,7-dihydroxy-3...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2014.03.015
更新日期：2014-06-01 00:00:00
abstract：:Eight new flavonoids daemoflavans A-H, including two dimeric proanthocyanidins (1 and 2), four flavans (3-6), two 2-arylbenzofurans (7 and 8), along with nine known compounds (9-17), were isolated from the fruit of Daemonorops draco. Their structures, including the absolute configurations, were elucidated by extensive...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2020.104549
更新日期：2020-06-01 00:00:00
abstract：:Oral treatment with the water extracts of Scoparia dulcis whole aerial parts, at doses of 50, 100 and 200 mg/kg, dose dependently inhibited the indomethacin-induced gastric damages in rats. ...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2008.05.001
更新日期：2008-12-01 00:00:00
abstract：:Diabetes is a worldwide healthy concern, which affects approximately 9% of the population. Tetrahydrocurcumin (THC) is the main metabolite of curcumin, which exerts the anti-diabetic activity. However, the underlying mechanism has not been clarified. In the research, we investigated whether THC could improve diabetes ...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2020.104665
更新日期：2020-10-01 00:00:00
abstract：:The secondary metabolite pattern of Eryngium tricuspidatum has been found to be dominated by C17 acetylene oxylipins, according to the chemistry reported in the literature for the genus Eryngium. Two new oxylipins, 11-acetoxy-falcarindiol (4) and 1,2-dihydro-11-acetoxy-falcarindiol (5) have been isolated, along with m...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2019.104355
更新日期：2019-10-01 00:00:00
abstract：:The flavonoid baicalein has been demonstrated to be an activator of the transcription factor Nrf2 in mammalian cell lines. We show that it further modulates the Nrf2 homolog SKN-1 in Caenorhabditis elegans and by this pathway mediates beneficial effects in the nematode: baicalein enhances the resistance of C. elegans ...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2016.06.018
更新日期：2016-09-01 00:00:00
abstract：:Escin exerts potent glucocorticoid-like anti-inflammatory effects. The aim of this study was to investigate whether the anti-inflammatory effect of escin is through the up-regulation of glucocorticoids and if escin induces pathological changes in immune organs. Mice were administrated with escin intravenously for 7 da...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2011.04.004
更新日期：2011-09-01 00:00:00
abstract：:Wedelia (Sphagneticola trilobata, Syn. Wedelia trilobata), a notoriously invasive agricultural weed, can inhibit the growth and development of crops in the field. Eight new eudesmanolides (1-8), along with twelve known congeners (9-20), were isolated and identified from the flowers of Wedelia. Their chemical structure...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2019.104452
更新日期：2020-04-01 00:00:00
abstract：:Two triglycerides, both bearing polyunsaturated fatty acid residues, were isolated from the hexane extract of Urena lobata. One of them is characterized by the presence of three different polyunsaturated fatty acids. Their structures were studied with spectral methods. ...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2006.03.010
更新日期：2006-06-01 00:00:00
abstract：:A stimulatory effect of apigenin-6-C-β-fucopyranoside (1) on glucose uptake was observed when rat soleus muscle was incubated with 1, 10 and 100 μM of this flavonoid glycoside. The presence of specific insulin signaling inhibitors, such as wortmannin, an inhibitor of phosphoinositide 3-kinase (PI3K), RO318220, an inhi...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2012.07.003
更新日期：2012-10-01 00:00:00
abstract：:Claims that Traditional/Alternative medicine (TM/AM) remedies are effective are routinely ignored by Western Medicine. However, the results of a clinical trial that demonstrated the clinical efficacy of Tripterygium wilfordii Hook F. (TW), a TM used as an anti-inflammatory, were recently published in the Annals of Int...
journal_title：Fitoterapia
pub_type： 杂志文章,评审
doi：10.1016/j.fitote.2010.11.024
更新日期：2011-01-01 00:00:00
abstract：:Ten new highly oxygenated lanostane triterpenoids, stereinones A-J (1-10), were isolated from the fruiting bodies of the basidiomycete Stereum sp. Compounds 3 and 4 are structurally characterized as intact lanostane-type triterpenoids containing unusual 1,2-diketone functionality at C-11 and C-12, while compound 10 is...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2017.11.020
更新日期：2018-03-01 00:00:00
abstract：:Five new phthalides (1-4, 6), two new natural products (5, 7) and five known phthalides (8-12) were isolated from the aerial parts of Ligusticum sinense Oliv cv. Chaxiong. Their structures were elucidated by HR-ESI-MS, UV, IR, 1D and 2D NMR (HSQC, HMBC, (1)H-(1)H COSY, NOESY) methods. The absolute configurations were ...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2014.01.010
更新日期：2014-03-01 00:00:00
