Abstract：
:Transfer of human chromosome 11, which contains the myoD locus, from primary fibroblasts into 10T1/2 cells results in activation of myoD. In contrast, hybrids that retain human chromosome 11 and additional human chromosomes fail to activate myoD. We show that human chromosome 4 inhibits myoD activation. myoD enhancer/promoter reporter constructs show that repression is at the transcriptional level. Chromosome fragment-containing hybrids localize the repressing activity to the region of 4p that contains the homeobox gene MSX1. MSX1 is expressed in primary human fibroblasts and in 10T1/2 cells containing human chromosome 4, while parental 10T1/2 cells do not express Msx1. Forced expression of Msx1 represses myoD enhancer activity. Msx1 protein binds to the myoD enhancer and likely represses myoD transcription directly. Antisense MSX1 relieves repression mediated by chromosome 4. We conclude that MSX1 inhibits transcription of myoD and that myoD is a target for homeobox gene regulation.
journal_name
Celljournal_title
Cellauthors
Woloshin P,Song K,Degnin C,Killary AM,Goldhamer DJ,Sassoon D,Thayer MJdoi
10.1016/0092-8674(95)90033-0subject
Has Abstractpub_date
1995-08-25 00:00:00pages
611-20issue
4eissn
0092-8674issn
1097-4172pii
0092-8674(95)90033-0journal_volume
82pub_type
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