Abstract：
:We describe a monoclonal antibody directed against a neuron-specific mitochondrial protein from rat brain. On protein blots the antibody recognizes a single polypeptide of apparent molecular weight of 23,000. By solid-phase immunoassay the antigen was detected in nonneural tissues. Within neurons, the antibody stains cytoplasmic granules that immunoelectron microscopy shows are mitochondria, hence the designation MIT-23. Immunocytochemical staining of the cerebellar cortex showed that MIT-23 occurs in all the neuronal types but is absent from glial and other nonneuronal cells. During neonatal development of the cerebellum, MIT-23 appears in neurons after their final cell division or migration is completed, suggesting that specific proteins associated with mitochondria participate in neuronal maturation.
journal_name
Celljournal_title
Cellauthors
Hawkes R,Niday E,Matus Adoi
10.1016/0092-8674(82)90343-9subject
Has Abstractpub_date
1982-02-01 00:00:00pages
253-8issue
2eissn
0092-8674issn
1097-4172pii
0092-8674(82)90343-9journal_volume
28pub_type
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