当前位置： SCI文献检索 > CELL期刊下所有文献 > Origins and fates of cardiovascular progenitor cells.

Origins and fates of cardiovascular progenitor cells.

Abstract：

:Multipotent cardiac progenitor cells are found in the fetal and adult heart of many mammalian species including humans and form as intermediates during the differentiation of embryonic stem cells. Despite similar biological properties, the molecular identities of these different cardiac progenitor cell populations appear to be distinct. Elucidating the origins and lineage relationships of these cell populations will accelerate clinical applications such as drug screening and cell therapy as well as shedding light on the pathogenic mechanisms underlying cardiac diseases.

journal_name

Cell

journal_title

Cell

authors

Wu SM,Chien KR,Mummery C

doi

10.1016/j.cell.2008.02.002

subject

Has Abstract

pub_date

2008-02-22 00:00:00

pages

537-43

issue

4

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(08)00201-8

journal_volume

132

pub_type

杂志文章

相关文献

CELL文献大全
  • Lifted Up from Lockdown.

    abstract：:The pandemic has impacted every scientist differently. Many negative impacts are frequently discussed. Here we highlight unexpected positives that we have found and hope will persist: improved access to experts; deeper and broader human engagement among colleagues, collaborators, and competitors; and significant democ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2020.09.027

    authors： Arturo EC,Saphire EO

    更新日期：2020-10-01 00:00:00

  • The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient.

    abstract：:Rhythmic cardiac contractions depend on the organized propagation of depolarizing and repolarizing wavefronts. Repolarization is spatially heterogeneous and depends largely on gradients of potassium currents. Gradient disruption in heart disease may underlie susceptibility to fatal arrhythmias, but it is not known how...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2005.08.004

    authors： Costantini DL,Arruda EP,Agarwal P,Kim KH,Zhu Y,Zhu W,Lebel M,Cheng CW,Park CY,Pierce SA,Guerchicoff A,Pollevick GD,Chan TY,Kabir MG,Cheng SH,Husain M,Antzelevitch C,Srivastava D,Gross GJ,Hui CC,Backx PH,Bruneau

    更新日期：2005-10-21 00:00:00

  • The regulatory light chain of nonmuscle myosin is encoded by spaghetti-squash, a gene required for cytokinesis in Drosophila.

    abstract：:Two independent approaches to understanding the molecular mechanism of cytokinesis have converged on the gene spaghetti-squash (sqh). A genetic screen for mitotic mutants identified sqh1, a mutation that disrupts cytokinesis, which was then cloned by transposon tagging. Independently, the gene that encodes the regulat...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(91)90013-o

    authors： Karess RE,Chang XJ,Edwards KA,Kulkarni S,Aguilera I,Kiehart DP

    更新日期：1991-06-28 00:00:00

  • Requirement of yeast RAD2, a homolog of human XPG gene, for efficient RNA polymerase II transcription. implications for Cockayne syndrome.

    abstract：:In addition to xeroderma pigmentosum, mutations in the human XPG gene cause early onset Cockayne syndrome (CS). Here, we provide evidence for the involvement of RAD2, the S. cerevisiae counterpart of XPG, in promoting efficient RNA polymerase II transcription. Inactivation of RAD26, the S. cerevisiae counterpart of th...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/s0092-8674(02)00795-x

    authors： Lee SK,Yu SL,Prakash L,Prakash S

    更新日期：2002-06-28 00:00:00

  • Calorie restriction--the SIR2 connection.

    abstract：:A nutritious diet low in calories improves the health and extends the life span of rodents. Recent studies identified a gene, SIR2, which encodes an NAD-dependent deacetylase and may mediate the effects of calorie restriction. In this review, we discuss SIR2 genes and calorie restriction in the lower organisms yeast a...

    journal_title：Cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.cell.2005.01.029

    authors： Guarente L,Picard F

    更新日期：2005-02-25 00:00:00

  • SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel.

    abstract：:Maintenance of a constant cell volume in response to extracellular or intracellular osmotic changes is critical for cellular homeostasis. Activation of a ubiquitous volume-regulated anion channel (VRAC) plays a key role in this process; however, its molecular identity in vertebrates remains unknown. Here, we used a ce...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2014.03.024

    authors： Qiu Z,Dubin AE,Mathur J,Tu B,Reddy K,Miraglia LJ,Reinhardt J,Orth AP,Patapoutian A

    更新日期：2014-04-10 00:00:00

  • Molecular analysis of the histone gene cluster of psammechinus miliaris: II. The arrangement of the five histone-coding and spacer sequences.

    abstract：:Histone DNA of Psammechinus miliaris was obtained in an enriched form by buoyant density gradient centrifugation and was cleaved into 6 kb repeat units (Birnstiel et al., 1975a) by the action of the specific endonucleases EcoRI and HindIII. Since it was suspected that the 6 kb unit harbored all five histone-coding seq...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(76)90214-2

    authors： Schaffner W,Gross K,Telford J,Birnstiel M

    更新日期：1976-08-01 00:00:00

  • The ATAC acetyltransferase complex coordinates MAP kinases to regulate JNK target genes.

    abstract：:In response to extracellular cues, signal transduction activates downstream transcription factors like c-Jun to induce expression of target genes. We demonstrate that the ATAC (Ada two A containing) histone acetyltransferase (HAT) complex serves as a transcriptional cofactor for c-Jun at the Jun N-terminal kinase (JNK...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2010.07.045

    authors： Suganuma T,Mushegian A,Swanson SK,Abmayr SM,Florens L,Washburn MP,Workman JL

    更新日期：2010-09-03 00:00:00

  • Applied force reveals mechanistic and energetic details of transcription termination.

    abstract：:Transcription termination by bacterial RNA polymerase (RNAP) occurs at sequences coding for a GC-rich RNA hairpin followed by a U-rich tract. We used single-molecule techniques to investigate the mechanism by which three representative terminators (his, t500, and tR2) destabilize the elongation complex (EC). For his a...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2008.01.027

    authors： Larson MH,Greenleaf WJ,Landick R,Block SM

    更新日期：2008-03-21 00:00:00

  • Butyrate and related inhibitors of histone deacetylation block the induction of egg white genes by steroid hormones.

    abstract：:The short chain aliphatic acid salts, butyrate and propionate, are effective inhibitors of histone deacetylation in chick oviduct at 2--5 mM; they also prevent the hormonal induction of the ovalbumin and transferrin genes. The less potent deacetylase inhibitor isobutyrate is correspondingly less effective in blocking ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(80)90357-8

    authors： McKnight GS,Hager L,Palmiter RD

    更新日期：1980-11-01 00:00:00

  • The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.

    abstract：:Histone methylation regulates chromatin structure and transcription. The recently identified histone demethylase lysine-specific demethylase 1 (LSD1) is chemically restricted to demethylation of only mono- and di- but not trimethylated histone H3 lysine 4 (H3K4me3). We show that the X-linked mental retardation (XLMR) ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2007.02.017

    authors： Iwase S,Lan F,Bayliss P,de la Torre-Ubieta L,Huarte M,Qi HH,Whetstine JR,Bonni A,Roberts TM,Shi Y

    更新日期：2007-03-23 00:00:00

  • Initiating cellular stress responses.

    abstract：:The phosphoinositide 3-kinase related kinases (PIKKs) mediate responses to diverse stresses, including DNA double-strand breaks (DSBs), abnormal replication fork progression, the recognition of premature termination codons in mRNAs, and inadequate nutrient availability. Rigorous control of these kinases limits cellula...

    journal_title：Cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.cell.2004.06.023

    authors： Bakkenist CJ,Kastan MB

    更新日期：2004-07-09 00:00:00

  • Rhythmic modulation of the hematopoietic niche through neutrophil clearance.

    abstract：:Unique among leukocytes, neutrophils follow daily cycles of release from and migration back into the bone marrow, where they are eliminated. Because removal of dying cells generates homeostatic signals, we explored whether neutrophil elimination triggers circadian events in the steady state. Here, we report that the h...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2013.04.040

    authors： Casanova-Acebes M,Pitaval C,Weiss LA,Nombela-Arrieta C,Chèvre R,A-González N,Kunisaki Y,Zhang D,van Rooijen N,Silberstein LE,Weber C,Nagasawa T,Frenette PS,Castrillo A,Hidalgo A

    更新日期：2013-05-23 00:00:00

  • Hybrid transfer RNA genes in phage T4.

    abstract：:We describe the isolation and characterization of two unusual amber suppressor forms of T4 tRNALeu. The sequences of the suppressor tRNAs can be described as hybrids of wild-type tRNALeu and suppressor tRNAGln molecules: the chain lengths and majority of the nucleotide residues corresponded to tRNALeu, but CUA anticod...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(84)90544-0

    authors： McClain WH,Foss K

    更新日期：1984-08-01 00:00:00

  • Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p.

    abstract：:We have reproduced the posttranslational mode of protein translocation across the endoplasmic reticulum membrane with reconstituted proteoliposomes containing a purified complex of seven yeast proteins. This Sec complex includes a heterotrimeric Sec61p complex, homologous to that in mammals, as well as all other membr...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(95)90077-2

    authors： Panzner S,Dreier L,Hartmann E,Kostka S,Rapoport TA

    更新日期：1995-05-19 00:00:00

  • Solving mysteries of DNA replication and frog cloning.

    abstract：:Compared to sperm nuclei, nuclei from adult somatic cells replicate inefficiently in frog egg extract. In this issue of Cell, Lemaitre et al. (2005) show that pre-exposure of erythrocyte nuclei to a mitotic extract removes this difference, reorganizes the chromatin into shorter loops, and allows replication at much sh...

    journal_title：Cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.cell.2005.11.008

    authors： Laskey R

    更新日期：2005-12-02 00:00:00

  • A single mouse alpha-amylase gene specifies two different tissue-specific mRNAs.

    abstract：:The alpha-amylase mRNAs which accumulate in two different tissues of the mouse, the salivary gland and the liver, are identical except for their 5' non-translated sequences: the 5' terminal 158 nucleotides of the major liver alpha-amylase mRNA are unrelated to the 5' terminal 47 nucleotides found in its salivary gland...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(81)90140-9

    authors： Young RA,Hagenbüchle O,Schibler U

    更新日期：1981-02-01 00:00:00

  • Inhibition of DNA methylation by chemical carcinogens in vitro.

    abstract：:A diverse range of ultimate chemical carcinogens inhibited the transfer of methyl groups from S-adenosylmethionine to hemimethylated DNA in a reaction catalyzed by mouse spleen methyltransferase. The formation of alkali-labile sites in DNA lessened its ability to accept methyl groups in vitro, but the methylation reac...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(83)90514-7

    authors： Wilson VL,Jones PA

    更新日期：1983-01-01 00:00:00

  • Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments.

    abstract：:Many body surfaces harbor organ-specific γδ T cell compartments that contribute to tissue integrity. Thus, murine dendritic epidermal T cells (DETCs) uniquely expressing T cell receptor (TCR)-Vγ5 chains protect from cutaneous carcinogens. The DETC repertoire is shaped by Skint1, a butyrophilin-like (Btnl) gene express...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2016.08.030

    authors： Di Marco Barros R,Roberts NA,Dart RJ,Vantourout P,Jandke A,Nussbaumer O,Deban L,Cipolat S,Hart R,Iannitto ML,Laing A,Spencer-Dene B,East P,Gibbons D,Irving PM,Pereira P,Steinhoff U,Hayday A

    更新日期：2016-09-22 00:00:00

  • Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome.

    abstract：:Nijmegen breakage syndrome (NBS) is an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Cells from NBS patients are hypersensitive to ionizing radiation with cytogenetic features indistinguishable from ataxia telangiect...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/s0092-8674(00)81174-5

    authors： Varon R,Vissinga C,Platzer M,Cerosaletti KM,Chrzanowska KH,Saar K,Beckmann G,Seemanová E,Cooper PR,Nowak NJ,Stumm M,Weemaes CM,Gatti RA,Wilson RK,Digweed M,Rosenthal A,Sperling K,Concannon P,Reis A

    更新日期：1998-05-01 00:00:00

  • Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference.

    abstract：:Csm, a type III-A CRISPR-Cas interference complex, is a CRISPR RNA (crRNA)-guided RNase that also possesses target RNA-dependent DNase and cyclic oligoadenylate (cOA) synthetase activities. However, the structural features allowing target RNA-binding-dependent activation of DNA cleavage and cOA generation remain unkno...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2018.10.052

    authors： You L,Ma J,Wang J,Artamonova D,Wang M,Liu L,Xiang H,Severinov K,Zhang X,Wang Y

    更新日期：2019-01-10 00:00:00

  • Tumor promoter-induced changes in the permeability of epithelial cell tight junctions.

    abstract：:Treatment of the kidney epithelial cell line MDCK with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) induces a large increase in the permeability of tight junctions within 2-4 hr. This change in transepithelial permeability is accompanied by alterations in cell morphology that include the opening of ti...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(81)90274-9

    authors： Ojakian GK

    更新日期：1981-01-01 00:00:00

  • CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice.

    abstract：:Oligodendrocyte-specific protein (OSP)/claudin-11 is a recently identified transmembrane protein found in CNS myelin and testis with unknown function. Herein we demonstrate that Osp null mice exhibit both neurological and reproductive deficits: CNS nerve conduction is slowed, hindlimb weakness is conspicuous, and male...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/s0092-8674(00)81553-6

    authors： Gow A,Southwood CM,Li JS,Pariali M,Riordan GP,Brodie SE,Danias J,Bronstein JM,Kachar B,Lazzarini RA

    更新日期：1999-12-10 00:00:00

  • Nucleoporins directly stimulate expression of developmental and cell-cycle genes inside the nucleoplasm.

    abstract：:Nuclear pore complexes (NPCs) mediate transport across the nuclear envelope. In yeast, they also interact with active genes, attracting or retaining them at the nuclear periphery. In higher eukaryotes, some NPC components (nucleoporins) are also found in the nucleoplasm, with a so far unknown function. We have functio...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2010.01.011

    authors： Kalverda B,Pickersgill H,Shloma VV,Fornerod M

    更新日期：2010-02-05 00:00:00

  • A comparison of the structure of chicken erythrocyte and chicken liver chromatin.

    abstract：:The structure of chicken erythrocyte and chicken liver chromatin has been studied by enzymatic digestion with micrococcal nuclease and DNAase I. Comparison of the fragments produced by brief digestion with micrococcal nuclease indicates that chicken erythrocyte chromatin has a longer nucleosome repeat than chicken liv...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(76)90045-3

    authors： Morris NR

    更新日期：1976-12-01 00:00:00

  • Doubling Down on Mutant RAS Can MEK or Break Leukemia.

    abstract：:Targeting of the RAS pathway has long been a critical therapeutic challenge in oncology. Burgess et al. examine how the relative expression of mutant and wild-type KRAS modulates clonal fitness and sensitivity to MEK inhibitors in a model of KrasG12D mutant acute myeloid leukemia and propose its use as a predictive bi...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2017.02.013

    authors： Tothova Z,Ebert BL

    更新日期：2017-02-23 00:00:00

  • Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells.

    abstract：:In dividing cells, nuclear pore complexes (NPCs) disassemble during mitosis and reassemble into the newly forming nuclei. However, the fate of nuclear pores in postmitotic cells is unknown. Here, we show that NPCs, unlike other nuclear structures, do not turn over in differentiated cells. While a subset of NPC compone...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2008.11.037

    authors： D'Angelo MA,Raices M,Panowski SH,Hetzer MW

    更新日期：2009-01-23 00:00:00

  • Observing a DNA polymerase choose right from wrong.

    abstract：:DNA polymerase (pol) β is a model polymerase involved in gap-filling DNA synthesis utilizing two metals to facilitate nucleotidyl transfer. Previous structural studies have trapped catalytic intermediates by utilizing substrate analogs (dideoxy-terminated primer or nonhydrolysable incoming nucleotide). To identify add...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2013.05.048

    authors： Freudenthal BD,Beard WA,Shock DD,Wilson SH

    更新日期：2013-07-03 00:00:00

  • Neither methylating nor demethylating enzymes are required for bacterial chemotaxis.

    abstract：:Clarification of the information processing system in bacterial sensing has been obtained by studying mutants that lack the capacity to modify receptors covalently. The remaining part of the system is able to receive signals from the receptor, to respond with partial adaptation, and to exhibit a chemotactic response. ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(85)90125-4

    authors： Stock J,Kersulis G,Koshland DE Jr

    更新日期：1985-09-01 00:00:00

  • Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals.

    abstract：:The commitment complex is the first defined step in the yeast (S. cerevisiae) splicing pathway. It contains U1 snRNP as well as Mud2p, which resembles human U2AF65. In a genetic screen, we identified the yeast gene MSL-5, which is a novel commitment complex component. Genetic and biochemical criteria indicate a direct...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/s0092-8674(00)80221-4

    authors： Abovich N,Rosbash M

    更新日期：1997-05-02 00:00:00