Abstract：
:Targeting of the RAS pathway has long been a critical therapeutic challenge in oncology. Burgess et al. examine how the relative expression of mutant and wild-type KRAS modulates clonal fitness and sensitivity to MEK inhibitors in a model of KrasG12D mutant acute myeloid leukemia and propose its use as a predictive biomarker.
journal_name
Celljournal_title
Cellauthors
Tothova Z,Ebert BLdoi
10.1016/j.cell.2017.02.013subject
Has Abstractpub_date
2017-02-23 00:00:00pages
749-750issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(17)30191-5journal_volume
168pub_type
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