Role of Drosophila alpha-adaptin in presynaptic vesicle recycling.

abstract：:DNA polymerase (pol) β is a model polymerase involved in gap-filling DNA synthesis utilizing two metals to facilitate nucleotidyl transfer. Previous structural studies have trapped catalytic intermediates by utilizing substrate analogs (dideoxy-terminated primer or nonhydrolysable incoming nucleotide). To identify add...

journal_title：Cell

authors： Freudenthal BD,Beard WA,Shock DD,Wilson SH

更新日期：2013-07-03 00:00:00

abstract：:Malignant gliomas are aggressive brain tumors with limited therapeutic options, and improvements in treatment require a deeper molecular understanding of this disease. As in other cancers, recent studies have identified highly tumorigenic subpopulations within malignant gliomas, known generally as cancer stem cells. H...

journal_title：Cell

authors： Eyler CE,Wu Q,Yan K,MacSwords JM,Chandler-Militello D,Misuraca KL,Lathia JD,Forrester MT,Lee J,Stamler JS,Goldman SA,Bredel M,McLendon RE,Sloan AE,Hjelmeland AB,Rich JN

更新日期：2011-07-08 00:00:00

abstract：:The Polycomb group (Pc-G) proteins are responsible for keeping developmental regulators, like homeotic genes, stably and inheritably repressed during Drosophila development. Several similarities to a protein class involved in heterochromatin formation suggest that the Pc-G exerts its function at the higher order chrom...

journal_title：Cell

authors： Orlando V,Paro R

更新日期：1993-12-17 00:00:00

abstract：:We have fused DNA fragments derived from an Escherichia coli tRNALeu1 operon to the galK gene of E. coli to identify sequences necessary for the in vivo initiation of transcription and growth-rate-dependent regulation. Promoter sequences consisting of residues from -50 to +56 or -50 to +5 with respect to the in vivo s...

journal_title：Cell

authors： Duester G,Elford RM,Holmes WM

更新日期：1982-10-01 00:00:00

abstract：:The precise control of miR-17∼92 microRNA (miRNA) is essential for normal development, and overexpression of certain miRNAs from this cluster is oncogenic. Here, we find that the relative expression of the six miRNAs processed from the primary (pri-miR-17∼92) transcript is dynamically regulated during embryonic stem c...

journal_title：Cell

authors： Du P,Wang L,Sliz P,Gregory RI

更新日期：2015-08-13 00:00:00

abstract：:Rhythmic cardiac contractions depend on the organized propagation of depolarizing and repolarizing wavefronts. Repolarization is spatially heterogeneous and depends largely on gradients of potassium currents. Gradient disruption in heart disease may underlie susceptibility to fatal arrhythmias, but it is not known how...

journal_title：Cell

authors： Costantini DL,Arruda EP,Agarwal P,Kim KH,Zhu Y,Zhu W,Lebel M,Cheng CW,Park CY,Pierce SA,Guerchicoff A,Pollevick GD,Chan TY,Kabir MG,Cheng SH,Husain M,Antzelevitch C,Srivastava D,Gross GJ,Hui CC,Backx PH,Bruneau

更新日期：2005-10-21 00:00:00

abstract：:Affordable genome sequencing technologies promise to revolutionize the field of human genetics by enabling comprehensive studies that interrogate all classes of genome variation, genome-wide, across the entire allele frequency spectrum. Ongoing projects worldwide are sequencing many thousands-and soon millions-of huma...

journal_title：Cell

authors： Lappalainen T,Scott AJ,Brandt M,Hall IM

更新日期：2019-03-21 00:00:00

abstract：:Evidence is now mounting that liquid-liquid phase separation (LLPS) underlies the formation of membraneless compartments in cells. This realization has motivated major efforts to delineate the function of such biomolecular condensates in normal cells and their roles in contexts ranging from development to age-related ...

journal_title：Cell

authors： Alberti S,Gladfelter A,Mittag T

更新日期：2019-01-24 00:00:00

abstract：:The histone tails on the nucleosome surface are subject to enzyme-catalyzed modifications that may, singly or in combination, form a code specifying patterns of gene expression. Recent papers provide insights into how a combinatorial code might be set and read. They show how modification of one residue can influence t...

journal_title：Cell

authors： Turner BM

更新日期：2002-11-01 00:00:00

abstract：:Viral infection causes the host to activate an antiviral response that, in part, is dependent on mitochondrial antiviral signaling protein (MAVS) to stimulate type I interferons. Zhang et al. (2019) demonstrate that glucose-generated lactate interacts with MAVS to suppress type I interferons. This study links glucose ...

journal_title：Cell

authors： Stoolman JS,Chandel NS

更新日期：2019-06-27 00:00:00

abstract：:Activation of the transcription factor NF-kappaB by tumor necrosis factor (TNF) and interleukin-1 (IL-1) requires the NF-kappaB-inducing kinase (NIK). In a yeast two-hybrid screen for NIK-interacting proteins, we have identified a protein kinase previously known as CHUK. Overexpression of CHUK activates a NF-kappaB-de...

journal_title：Cell

authors： Régnier CH,Song HY,Gao X,Goeddel DV,Cao Z,Rothe M

更新日期：1997-07-25 00:00:00

abstract：:Determining which neurite of a differentiating neuron is to become the axon is a crucial step in neuronal morphogenesis. Two groups (Barnes et al., 2007; Shelly et al., 2007) now report that axon specification in vivo is mediated by extracellular signals acting through the serine/threonine kinase LKB1. ...

journal_title：Cell

authors： Winckler B

更新日期：2007-05-04 00:00:00

abstract：:Following EMS mutagenesis we recovered a mutant of D. melanogaster that grows at concentrations of alpha-amanitin lethal to wild-type. To our knowledge this mutant represents the first example of an amanitin-resistant eucaryotic organism. The amanitin resistance of the mutant (AmaC4) is due to an alteration in its DNA...

journal_title：Cell

authors： Greenleaf AL,Borsett LM,Jiamachello PF,Coulter DE

更新日期：1979-11-01 00:00:00

abstract：:We have identified a gene, SRV2, mutations of which alleviate stress sensitivity in strains carrying an activated RAS gene. Epistasis analysis suggests that the gene affects accumulation of cAMP in the cell. Direct assays of cAMP accumulation indicate that mutations of the gene diminish the rate of in vivo production ...

journal_title：Cell

authors： Fedor-Chaiken M,Deschenes RJ,Broach JR

更新日期：1990-04-20 00:00:00

abstract：:KRASG12C was recently identified to be potentially druggable by allele-specific covalent targeting of Cys-12 in vicinity to an inducible allosteric switch II pocket (S-IIP). Success of this approach requires active cycling of KRASG12C between its active-GTP and inactive-GDP conformations as accessibility of the S-IIP ...

journal_title：Cell

authors： Janes MR,Zhang J,Li LS,Hansen R,Peters U,Guo X,Chen Y,Babbar A,Firdaus SJ,Darjania L,Feng J,Chen JH,Li S,Li S,Long YO,Thach C,Liu Y,Zarieh A,Ely T,Kucharski JM,Kessler LV,Wu T,Yu K,Wang Y,Yao Y,Deng X,

更新日期：2018-01-25 00:00:00

abstract：:Bacteria and archaea have evolved sophisticated adaptive immune systems that reply on CRISPR loci and a diverse cassette of Cas genes that are classified into three main types and at least eleven subtypes. All CRISPR-Cas immune systems operate through three main stages: acquisition, biogenesis, and interference. This ...

journal_title：Cell

authors： Carter J,Wiedenheft B

更新日期：2015-09-24 00:00:00

abstract：:Brassinosteroids (BRs) signal through a plasma membrane-localized receptor kinase to regulate plant growth and development. We showed previously that a novel protein, BES1, accumulates in the nucleus in response to BRs, where it plays a role in BR-regulated gene expression; however, the mechanism by which BES1 regulat...

journal_title：Cell

authors： Yin Y,Vafeados D,Tao Y,Yoshida S,Asami T,Chory J

更新日期：2005-01-28 00:00:00

abstract：:The chicken immunoglobulin light chain repertoire has been shown to be entirely derived from a single V lambda 1-J rearranged combination. The complete coding information of the lambda locus was determined: it comprises 25 V-hybridizing elements, all of which are pseudogenes, clustered in both orientations within 19 k...

journal_title：Cell

authors： Reynaud CA,Anquez V,Grimal H,Weill JC

更新日期：1987-02-13 00:00:00

abstract：:High-grade serous ovarian cancer (HGSC) exhibits extensive malignant clonal diversity with widespread but non-random patterns of disease dissemination. We investigated whether local immune microenvironment factors shape tumor progression properties at the interface of tumor-infiltrating lymphocytes (TILs) and cancer c...

journal_title：Cell

authors： Zhang AW,McPherson A,Milne K,Kroeger DR,Hamilton PT,Miranda A,Funnell T,Little N,de Souza CPE,Laan S,LeDoux S,Cochrane DR,Lim JLP,Yang W,Roth A,Smith MA,Ho J,Tse K,Zeng T,Shlafman I,Mayo MR,Moore R,Failmezger

更新日期：2018-06-14 00:00:00

abstract：:In the developing nervous system, neural progenitors exit the cell cycle and differentiate on a precise schedule, yet the mechanisms driving this process remain poorly defined. Yan et al. (2009) now identify a thiol-redox reaction mediated by the membrane protein GDE2 and the peroxiredoxin protein Prdx1 that promotes ...

journal_title：Cell

authors： Novitch BG,Butler SJ

更新日期：2009-09-18 00:00:00

abstract：:Accurately predicting an outcome requires that animals learn supporting and conflicting evidence from sequential experience. In mammals and invertebrates, learned fear responses can be suppressed by experiencing predictive cues without punishment, a process called memory extinction. Here, we show that extinction of av...

journal_title：Cell

authors： Felsenberg J,Jacob PF,Walker T,Barnstedt O,Edmondson-Stait AJ,Pleijzier MW,Otto N,Schlegel P,Sharifi N,Perisse E,Smith CS,Lauritzen JS,Costa M,Jefferis GSXE,Bock DD,Waddell S

更新日期：2018-10-18 00:00:00

abstract：:We have established the DNA sequence of nine yeast mutants that prevent the expression either of the split cytochrome b gene alone (five mutants) or of two split genes, the cytochrome b gene and the cytochrome oxidase subunit I gene (four mutants). All the mutations analyzed are localized in intron 14 of the cob-box g...

journal_title：Cell

authors： De La Salle H,Jacq C,Slonimski PP

更新日期：1982-04-01 00:00:00

abstract：:The X-ray crystal structures of an anti-p24 (HIV-1) monoclonal antibody Fab fragment alone and in complexes with the epitope peptide GATPQDLNTnL (n = norleucine), an epitope-homologous peptide GATPEDLNQKLAGN, as well as two unrelated peptides GLYEWGGARITNTD and efslkGpllqwrsG (D-peptide), are presented to a maximum re...

journal_title：Cell

authors： Keitel T,Kramer A,Wessner H,Scholz C,Schneider-Mergener J,Höhne W

更新日期：1997-12-12 00:00:00

abstract：:The nucleotide sequence from the 5' terminus inward of one third of mouse alpha- and beta maj-globin messenger RNAs has been established. In addition, using 5' 32P end-labeled mRNAs as substrates and S1 and T1 nucleases as probes for single-stranded regions, the secondary structures of mouse and rabbit alpha- and beta...

journal_title：Cell

authors： Pavlakis GN,Lockard RE,Vamvakopoulos N,Rieser L,RajBhandary UL,Vournakis JN

更新日期：1980-01-01 00:00:00

abstract：:Ischemia-associated oxidative damage leading to necrosis is a major cause of catastrophic tissue loss, and elucidating its signaling mechanism is therefore of paramount importance. p53 is a central stress sensor responding to multiple insults, including oxidative stress to orchestrate apoptotic and autophagic cell dea...

journal_title：Cell

authors： Vaseva AV,Marchenko ND,Ji K,Tsirka SE,Holzmann S,Moll UM

更新日期：2012-06-22 00:00:00

abstract：:Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequen...

journal_title：Cell

authors： Volz E,Hill V,McCrone JT,Price A,Jorgensen D,O'Toole Á,Southgate J,Johnson R,Jackson B,Nascimento FF,Rey SM,Nicholls SM,Colquhoun RM,da Silva Filipe A,Shepherd J,Pascall DJ,Shah R,Jesudason N,Li K,Jarrett R,Pacchi

更新日期：2021-01-07 00:00:00

abstract：:A basic B-cell-specific protein of 35,000 daltons (XM1) is expressed at a high rate--comparable to actin--in resting splenic B lymphocytes of various species. Splenic or thymic T cells or fibroblasts do not express this protein. Upon polyclonal stimulation of B lymphocytes or in proliferating B-lymphocyte-derived cell...

journal_title：Cell

authors： Rahmsdorf HJ,Mallick U,Ponta H,Herrlich P

更新日期：1982-06-01 00:00:00

abstract：:Extraction of glycerinated chicken skeletal muscle with 0.6 M potassium iodide leaves a framework of insoluble components within each muscle fiber. This framework is composed primarily of planes of in-register Z discs that have been thickened by the accumulation of material on both sides of each disc during extraction...

journal_title：Cell

authors： Granger BL,Lazarides E

更新日期：1978-12-01 00:00:00

abstract：:The eye lens contains a structural protein (alpha-crystallin), composed of two homologous primary gene products, alpha A2 and alpha B2. In certain rodents, there is another minor alpha-crystallin polypeptide, alpha Ains, which is identical to alpha A2 except for a 22 amino acid insert between residues 63 and 64 of the...

journal_title：Cell

authors： King CR,Piatigorsky J

更新日期：1983-03-01 00:00:00

abstract：:The protein kinase Akt occupies a central position in multiple signaling pathways. Although numerous Akt substrates have been identified, less is known about the factors that regulate specific cellular responses to Akt signaling. In this issue, Schenck et al. (2008) demonstrate that the endosomal protein Appl1 modulat...

journal_title：Cell

authors： Zhao S,Guan KL

更新日期：2008-05-02 00:00:00