Abstract：
:Animals learn to avoid harmful situations by associating a neutral stimulus with a painful one, resulting in a stable threat memory. In mammals, this form of learning requires the amygdala. Although pain is the main driver of aversive learning, the mechanism that transmits pain signals to the amygdala is not well resolved. Here, we show that neurons expressing calcitonin gene-related peptide (CGRP) in the parabrachial nucleus are critical for relaying pain signals to the central nucleus of amygdala and that this pathway may transduce the affective motivational aspects of pain. Genetic silencing of CGRP neurons blocks pain responses and memory formation, whereas their optogenetic stimulation produces defensive responses and a threat memory. The pain-recipient neurons in the central amygdala expressing CGRP receptors are also critical for establishing a threat memory. The identification of the neural circuit conveying affective pain signals may be pertinent for treating pain conditions with psychiatric comorbidities.
journal_name
Celljournal_title
Cellauthors
Han S,Soleiman MT,Soden ME,Zweifel LS,Palmiter RDdoi
10.1016/j.cell.2015.05.057subject
Has Abstractpub_date
2015-07-16 00:00:00pages
363-374issue
2eissn
0092-8674issn
1097-4172pii
S0092-8674(15)00775-8journal_volume
162pub_type
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