Abstract：
:Protein phosphorylation and protein ubiquitination regulate most aspects of cell life, and defects in these control mechanisms cause cancer and many other diseases. In the past decade, protein kinases have become one of the most important classes of drug targets for the pharmaceutical industry. In contrast, drug discovery programs that target components of the ubiquitin system have lagged behind. In this Perspective, we discuss the reasons for the delay in this pipeline, the drugs targeting the ubiquitin system that have been developed, and new approaches that may popularize this area of drug discovery in the future.
journal_name
Celljournal_title
Cellauthors
Cohen P,Tcherpakov Mdoi
10.1016/j.cell.2010.11.016subject
Has Abstractpub_date
2010-11-24 00:00:00pages
686-93issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(10)01296-1journal_volume
143pub_type
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