Abstract：
:Recessive lethal mutations in the T/t-complex of the mouse characteristically show defective genetic complementation, even when they affect very different stages of embryogenesis and are known to be nonallelic. To address the question of their genetic or functional relationship, we have applied the cis-trans test, using several well defined recombinant t-chromosomes that carry two or more lethal mutations, and others that are devoid of specific lethals. We show here that the defective complementation that occurs between different t-lethals is a specific result of the trans configuration; thus these genes, which may map as much as 15 cM apart, constitute a functional unit. Some speculations are presented to interpret this enigma in terms of DNA plasticity.
journal_name
Celljournal_title
Cellauthors
Shin HS,McCormick P,Artzt K,Bennett Ddoi
10.1016/0092-8674(83)90035-1subject
Has Abstractpub_date
1983-07-01 00:00:00pages
925-9issue
3eissn
0092-8674issn
1097-4172pii
0092-8674(83)90035-1journal_volume
33pub_type
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