On the nature of tetracycline resistance controlled by the plasmid pSC101.

abstract：:We have used liposomes to deliver DNAase I inside normal Syrian hamster embryo (SHE) cells. We showed the entrance of DNAase I inside the cell by dose-dependent cytotoxicity; and the entrance of DNAase I into the nucleus by the induction of chromosomal aberrations and somatic mutation at the HPRT locus (but not at the...

journal_title：Cell

authors： Zajac-Kaye M,Ts'o PO

更新日期：1984-12-01 00:00:00

abstract：:Transcriptional regulation by the glucocorticoid receptor (GR) is mediated by hormone binding, receptor dimerization, and coactivator recruitment. Here, we report the crystal structure of the human GR ligand binding domain (LBD) bound to dexamethasone and a coactivator motif derived from the transcriptional intermedia...

journal_title：Cell

authors： Bledsoe RK,Montana VG,Stanley TB,Delves CJ,Apolito CJ,McKee DD,Consler TG,Parks DJ,Stewart EL,Willson TM,Lambert MH,Moore JT,Pearce KH,Xu HE

更新日期：2002-07-12 00:00:00

abstract：:Netrins are bifunctional: they attract some axons and repel others. Netrin receptors of the Deleted in Colorectal Cancer (DCC) family are implicated in attraction and those of the UNC5 family in repulsion, but genetic evidence also suggests involvement of the DCC protein UNC-40 in some cases of repulsion. To test whet...

journal_title：Cell

authors： Hong K,Hinck L,Nishiyama M,Poo MM,Tessier-Lavigne M,Stein E

更新日期：1999-06-25 00:00:00

abstract：:An antiserum against material shed into serum-free medium by MCF-7 human mammary carcinoma cells (anti-SFM II) disrupts cell-cell interactions in murine mammary tumor epithelial cells (MMTE). We now report purification of an 80 kd glycoprotein (GP80) from SFM of MCF-7 mammary carcinoma cells that blocks the activity o...

journal_title：Cell

authors： Damsky CH,Richa J,Solter D,Knudsen K,Buck CA

更新日期：1983-09-01 00:00:00

abstract：:The achaete-scute gene complex (AS-C), involved in differentiation of the sensory chaetes of D. melanogaster, and the yellow locus have been cloned. The yellow locus is the most distal and is followed, proximally, by the achaete and the scute loci. In the scute locus (75 kb), three transcription units separated by lon...

journal_title：Cell

authors： Campuzano S,Carramolino L,Cabrera CV,Ruíz-Gómez M,Villares R,Boronat A,Modolell J

更新日期：1985-02-01 00:00:00

abstract：:Pathways that govern stem cell (SC) function are often subverted in cancer. Here, we report the isolation to near purity of human normal mammary SCs (hNMSCs), from cultured mammospheres, on the basis of their ability to retain the lipophilic dye PKH26 as a consequence of their quiescent nature. PKH26-positive cells po...

journal_title：Cell

authors： Pece S,Tosoni D,Confalonieri S,Mazzarol G,Vecchi M,Ronzoni S,Bernard L,Viale G,Pelicci PG,Di Fiore PP

更新日期：2010-01-08 00:00:00

abstract：:We have produced a series of somatic cell hybrids by fusing pluripotent PCC4aza1 embryonal carcinoma ("teretocarcinoma") cells with thymocytes from young adult mice. When these hybrids form tumors in nu/nu or syngeneic mice, all the tumors contain a range of differentiated tissues, as well as embryonal carcinoma-like ...

journal_title：Cell

authors： Miller RA,Ruddle FH

更新日期：1976-09-01 00:00:00

abstract：:The axonal shafts of neurons contain bundled microtubules, whereas extending growth cones contain unbundled microtubule filaments, suggesting that localized activation of microtubule-associated proteins (MAP) at the transition zone may bundle these filaments during axonal growth. Dephosphorylation is thought to lead t...

journal_title：Cell

authors： Bielas SL,Serneo FF,Chechlacz M,Deerinck TJ,Perkins GA,Allen PB,Ellisman MH,Gleeson JG

更新日期：2007-05-04 00:00:00

abstract：:Induction of senescence permanently restricts cellular proliferation after oncogenic stimulation thereby acting as a potent barrier to tumor development. The relevant effector proteins may therefore be fundamental to cancer development. A recent study identified IGFBP7 as a secreted factor mediating melanocyte senesce...

journal_title：Cell

authors： Scurr LL,Pupo GM,Becker TM,Lai K,Schrama D,Haferkamp S,Irvine M,Scolyer RA,Mann GJ,Becker JC,Kefford RF,Rizos H

更新日期：2010-05-14 00:00:00

abstract：:Basal cells are by definition located on the basolateral side of several epithelia, and they have never been observed reaching the lumen. Using high-resolution 3D confocal imaging, we report that basal cells extend long and slender cytoplasmic projections that not only reach toward the lumen but can cross the tight ju...

journal_title：Cell

authors： Shum WW,Da Silva N,McKee M,Smith PJ,Brown D,Breton S

更新日期：2008-12-12 00:00:00

abstract：:Cell surface complexes of class I MHC molecules and bound peptide antigens serve as specific recognition elements controlling the cytotoxic immune response. The 2.1 A structure of the human class I MHC molecule HLA-B27 provides a detailed composite image of a co-crystallized collection of HLA-B27-bound peptides, indic...

journal_title：Cell

authors： Madden DR,Gorga JC,Strominger JL,Wiley DC

更新日期：1992-09-18 00:00:00

abstract：:Senescence in Podospora anserina has long been shown to be under cytoplasmic control. Comparison of DNAs isolated from young and senescent cultures made it possible to detect the presence, in senescent cultures only, of a specific DNA (SEN-DNA). This DNA consists of repeated sequences arranged in a multimeric set of c...

journal_title：Cell

authors： Jamet-Vierny C,Begel O,Belcour L

更新日期：1980-08-01 00:00:00

abstract：:HNF-3 beta, a transcription factor of the winged-helix family, is expressed in embryonic and adult endoderm and also in midline cells of the node, notochord, and floor plate in mouse embryos. To define the function of HNF-3 beta, a targeted mutation in the HNF-3 beta locus was generated by homologous recombination in ...

journal_title：Cell

authors： Weinstein DC,Ruiz i Altaba A,Chen WS,Hoodless P,Prezioso VR,Jessell TM,Darnell JE Jr

更新日期：1994-08-26 00:00:00

abstract：:The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell ...

journal_title：Cell

authors： Hanahan D,Weinberg RA

更新日期：2011-03-04 00:00:00

abstract：:We have identified a yeast protein that binds specifically to the ARS consensus sequence. By two-step chromatography we have purified the factor to apparent homogeneity as a single polypeptide of 67 kd. The purified ARS consensus-binding protein (ACBP) recognizes the ARS consensus of the four genomic ARS elements test...

journal_title：Cell

authors： Hofmann JF,Gasser SM

更新日期：1991-03-08 00:00:00

abstract：:c-Myc (Myc) and Max proteins dimerize and bind DNA through basic-helix-loop-helix-leucine zipper motifs (b-HLH-LZ). Using a genetic approach, we demonstrate that binding to Max is essential for Myc transforming activity and that Myc homodimers are inactive. Mutants of Myc and Max that bind efficiently to each other bu...

journal_title：Cell

authors： Amati B,Brooks MW,Levy N,Littlewood TD,Evan GI,Land H

更新日期：1993-01-29 00:00:00

abstract：:Chronic viral infections represent a major burden to human health, and modulation of the immune system is emerging as a novel approach to fighting such infections. Pellegrini et al. (2011) demonstrate that treatment with the cytokine IL-7 may reinvigorate the immune response to persistent infection by targeting immuno...

journal_title：Cell

authors： Parish IA,Kaech SM

更新日期：2011-02-18 00:00:00

abstract：:The triskelion shape of the clathrin molecule enables it to form the polyhedral protein network that covers clathrin-coated pits and vesicles. Domains within the clathrin heavy chain that are responsible for maintaining triskelion shape and function were identified and localized. Sequences that mediate trimerization a...

journal_title：Cell

authors： Näthke IS,Heuser J,Lupas A,Stock J,Turck CW,Brodsky FM

更新日期：1992-03-06 00:00:00

abstract：:We have developed an in vitro system utilizing yeast cell-free extracts to catalyze recombination events between homologous plasmids containing different mutant alleles of the Tet or ARG4 genes. The reaction increased the frequency of Tcr or Arg+ transformants (recombinants) from 2 X 10(-6) to 1-3 X 10(-3). Linearizin...

journal_title：Cell

authors： Symington LS,Fogarty LM,Kolodner R

更新日期：1983-12-01 00:00:00

abstract：:The double-stranded RNA-activated protein kinase (PKR) was originally identified as a sensor of virus infection, but its function in the brain remains unknown. Here, we report that the lack of PKR enhances learning and memory in several behavioral tasks while increasing network excitability. In addition, loss of PKR i...

journal_title：Cell

authors： Zhu PJ,Huang W,Kalikulov D,Yoo JW,Placzek AN,Stoica L,Zhou H,Bell JC,Friedlander MJ,Krnjević K,Noebels JL,Costa-Mattioli M

更新日期：2011-12-09 00:00:00

abstract：:Several recent papers show that differences in histone modification and the use of histone variants at the 5' and 3' ends of genes influence the location and kinetics of transcriptional initiation. The ultimate target of most epigenetic mechanisms may be the regulation of nucleosome occupancy, which in turn controls a...

journal_title：Cell

authors： Lieb JD,Clarke ND

更新日期：2005-12-29 00:00:00

abstract：:It was previously demonstrated that the 60,000 dalton (p60) precursor-like polyprotein containing murine p30 was a constituent of the feline leukemia virus pseudotype of Moloney sarcoma virus [m1MSV(FeLV)]. It is now shown that p60 is detected in cells of five mammalian species transformed by m1MSV, indicating that p...

journal_title：Cell

authors： Robey WG,Oskarsson MK,Vande Woude GF,Naso RB,Arlinghaus RB,Haapala DK,Fischinger PJ

更新日期：1977-01-01 00:00:00

abstract：:Inconsistent with the view that hair follicle stem cells reside in the matrix area of the hair bulb, we found that label-retaining cells exist exclusively in the bulge area of the mouse hair follicle. The bulge consists of a subpopulation of outer root sheath cells located in the midportion of the follicle at the arre...

journal_title：Cell

authors： Cotsarelis G,Sun TT,Lavker RM

更新日期：1990-06-29 00:00:00

abstract：:We demonstrate that mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT), two inherited conditions characterized by altered calcium homeostasis. The Ca(2+)-sensing receptor belongs to the superfamily of seven membrane-spann...

journal_title：Cell

authors： Pollak MR,Brown EM,Chou YH,Hebert SC,Marx SJ,Steinmann B,Levi T,Seidman CE,Seidman JG

更新日期：1993-12-31 00:00:00

abstract：:Serum response factor (SRF) forms a ternary complex at the c-fos serum response element (SRE) with an accessory factor, Elk-1. We constructed altered-binding specificity derivatives of SRF and Elk-1 that form a ternary complex at a mutated, inactive SRE; like Elk-1, the Elk-1 variant only binds its target as part of a...

journal_title：Cell

authors： Hill CS,Marais R,John S,Wynne J,Dalton S,Treisman R

更新日期：1993-04-23 00:00:00

abstract：:A study in this issue of Cell illustrates the power of applying genomic approaches with model systems to characterize the biological activity of small molecules and to identify their cellular targets, which can clarify the mode of action of human therapeutics. ...

journal_title：Cell

authors： Hughes T,Andrews B,Boone C

更新日期：2004-01-09 00:00:00

abstract：:The leader RNA transcript of vesicular stomatitis virus (VSV) has been immunoprecipitated from infected BHK cell extracts by anti-La specific sera from patients with systemic lupus erythematosus (SLE). This association was specific as lupus anti-sera with other specificities failed to precipitate leader RNA. The amoun...

journal_title：Cell

authors： Kurilla MG,Keene JD

更新日期：1983-10-01 00:00:00

abstract：:In a screen for genes that interact with the Rap1 GTPase, we have identified a Drosophila gene, dacapo (dap), which is a member of the p21/p27 family of cdk inhibitors. Unlike mammalian cdk inhibitors studied to date, dap is essential for normal embryonic development. Dacapo inhibits cyclin-cdk activity in vitro. Over...

journal_title：Cell

authors： de Nooij JC,Letendre MA,Hariharan IK

更新日期：1996-12-27 00:00:00

abstract：:Epigenetic inheritance is more widespread in plants than in mammals, in part because mammals erase epigenetic information by germline reprogramming. We sequenced the methylome of three haploid cell types from developing pollen: the sperm cell, the vegetative cell, and their precursor, the postmeiotic microspore, and f...

journal_title：Cell

authors： Calarco JP,Borges F,Donoghue MT,Van Ex F,Jullien PE,Lopes T,Gardner R,Berger F,Feijó JA,Becker JD,Martienssen RA

更新日期：2012-09-28 00:00:00

abstract：:Membrane traffic in eukaryotic cells involves transport of vesicles that bud from a donor compartment and fuse with an acceptor compartment. Common principles of budding and fusion have emerged, and many of the proteins involved in these events are now known. However, a detailed picture of an entire trafficking organe...

journal_title：Cell

authors： Takamori S,Holt M,Stenius K,Lemke EA,Grønborg M,Riedel D,Urlaub H,Schenck S,Brügger B,Ringler P,Müller SA,Rammner B,Gräter F,Hub JS,De Groot BL,Mieskes G,Moriyama Y,Klingauf J,Grubmüller H,Heuser J,Wieland F,Jah

更新日期：2006-11-17 00:00:00