Abstract：
:We have produced a series of somatic cell hybrids by fusing pluripotent PCC4aza1 embryonal carcinoma ("teretocarcinoma") cells with thymocytes from young adult mice. When these hybrids form tumors in nu/nu or syngeneic mice, all the tumors contain a range of differentiated tissues, as well as embryonal carcinoma-like tissues. Some of the tumors produce alpha-fetoprotein. These results show that pluripotency in embryonal carcinoma cells need not to be abolished by the introduction of a complete diploid genome from a differentiated cell.
journal_name
Celljournal_title
Cellauthors
Miller RA,Ruddle FHdoi
10.1016/0092-8674(76)90051-9subject
Has Abstractpub_date
1976-09-01 00:00:00pages
45-55issue
1eissn
0092-8674issn
1097-4172pii
0092-8674(76)90051-9journal_volume
9pub_type
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