Human l1 retrotransposition is associated with genetic instability in vivo.

abstract：:Beta-arrestin1 is a multifunctional protein critically involved in signal transduction. Recently, it is also identified as a nuclear transcriptional regulator, but the underlying mechanisms and physiological significance remain to be explored. Here, we identified beta-arrestin1 as an evolutionarily conserved protein e...

journal_title：Cell

authors： Yue R,Kang J,Zhao C,Hu W,Tang Y,Liu X,Pei G

更新日期：2009-10-30 00:00:00

abstract：:Cell differentiation is an essential process for the development, growth, reproduction, and longevity of all multicellular organisms, and its regulation has been the focus of intense investigation for the past four decades. The study of natural and induced stem cells has ushered an age of re-examination of what it mea...

journal_title：Cell

authors： Sánchez Alvarado A,Yamanaka S

更新日期：2014-03-27 00:00:00

abstract：:In female mammals a "random choice" mechanism decides which of the two X chromosomes will be inactivated. It has been postulated that Xist is crucial for heterochromatinization and thus functions downstream of the choice mechanism. Here we report that females heterozygous for an internal deletion in the Xist gene, whi...

journal_title：Cell

authors： Marahrens Y,Loring J,Jaenisch R

更新日期：1998-03-06 00:00:00

abstract：:Induction of senescence permanently restricts cellular proliferation after oncogenic stimulation thereby acting as a potent barrier to tumor development. The relevant effector proteins may therefore be fundamental to cancer development. A recent study identified IGFBP7 as a secreted factor mediating melanocyte senesce...

journal_title：Cell

authors： Scurr LL,Pupo GM,Becker TM,Lai K,Schrama D,Haferkamp S,Irvine M,Scolyer RA,Mann GJ,Becker JC,Kefford RF,Rizos H

更新日期：2010-05-14 00:00:00

abstract：:The Bcl-2 family proteins are key regulators of apoptosis in human diseases and cancers. Though known to block apoptosis, Bcl-2 promotes cell death through an undefined mechanism. Here, we show that Bcl-2 interacts with orphan nuclear receptor Nur77 (also known as TR3), which is required for cancer cell apoptosis indu...

journal_title：Cell

authors： Lin B,Kolluri SK,Lin F,Liu W,Han YH,Cao X,Dawson MI,Reed JC,Zhang XK

更新日期：2004-02-20 00:00:00

abstract：:Multidrug resistance in human cells results from increased expression of the mdr1 (P-glycoprotein) gene. Although the same gene is activated in cells selected with different drugs, multidrug-resistant cell lines can be preferentially resistant to their selecting agent. The mdr1 cDNA sequence from vinblastine-selected ...

journal_title：Cell

authors： Choi KH,Chen CJ,Kriegler M,Roninson IB

更新日期：1988-05-20 00:00:00

abstract：:The use of optogenetic approaches has revealed new roles for intracellular protein condensates described in two papers in this issue of Cell (Bracha et. al., 2018; Shin et al., 2018). These results show that growing condensates are able to exert mechanical forces resulting in chromatin rearrangement, establishing a ne...

journal_title：Cell

authors： Welsh TJ,Shen Y,Levin A,Knowles TPJ

更新日期：2018-11-29 00:00:00

abstract：:Tumor suppressors block the development of cancer and are often lost during tumor development. Papa et al. show that partial loss of normal PTEN tumor suppressor function can be compounded by additional disruption caused by the expression of inactive mutant PTEN protein. This has significant implications for patients ...

journal_title：Cell

authors： Leslie NR,den Hertog J

更新日期：2014-04-24 00:00:00

abstract：:An easy manipulation of the commercial fluorescence microscope allows stereo pairs of pictures to be taken, which when examined with a stereo viewer, give a strong three-dimensional impression. The procedure is described in detail. Its use allows the documentation by immunofluorescence microscopy of the three-dimensio...

journal_title：Cell

authors： Osborn M,Born T,Koitsch HJ,Weber K

更新日期：1978-07-01 00:00:00

abstract：:Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover new antibiotics. To address this challenge, we trained a deep neural network capable of predicting molecules with antibacterial activity. We performed predictions on multiple chemical libraries and discovered a molecule fr...

journal_title：Cell

authors： Stokes JM,Yang K,Swanson K,Jin W,Cubillos-Ruiz A,Donghia NM,MacNair CR,French S,Carfrae LA,Bloom-Ackermann Z,Tran VM,Chiappino-Pepe A,Badran AH,Andrews IW,Chory EJ,Church GM,Brown ED,Jaakkola TS,Barzilay R,Collins J

更新日期：2020-02-20 00:00:00

abstract：:Methylation of deoxycytidine incorporated by DNA excision-repair was studied in human diploid fibroblasts following damage with ultraviolet radiation, N-methyl-N-nitrosourea, or N-acetoxy-2-acetylaminofluorene. In confluent, nondividing cells, methylation in repair patches induced by all three agents is slow and incom...

journal_title：Cell

authors： Kastan MB,Gowans BJ,Lieberman MW

更新日期：1982-09-01 00:00:00

abstract：:While the tumor suppressor functions of p53 have long been recognized, the contribution of p53 to numerous other aspects of disease and normal life is only now being appreciated. This burgeoning range of responses to p53 is reflected by an increasing variety of mechanisms through which p53 can function, although the a...

journal_title：Cell

authors： Vousden KH,Prives C

更新日期：2009-05-01 00:00:00

abstract：:During development, neurons switch among growth states, such as initial axon outgrowth, axon pruning, and regrowth. By studying the stereotypic remodeling of the Drosophila mushroom body (MB), we found that the heme-binding nuclear receptor E75 is dispensable for initial axon outgrowth of MB γ neurons but is required ...

journal_title：Cell

authors： Rabinovich D,Yaniv SP,Alyagor I,Schuldiner O

更新日期：2016-01-14 00:00:00

abstract：:Junctions that connect the endoplasmic reticulum (ER) and the plasma membrane (PM) are unique yet ubiquitous subcellular compartments. Giordano et al. now report that extended synaptotagmins (E-Syts) promote their formation, providing fundamental insight into the molecular machinery controlling ER and plasma membrane ...

journal_title：Cell

authors： Malmersjö S,Meyer T

更新日期：2013-06-20 00:00:00

abstract：:We have determined the nucleotide sequence of the transposable maize controlling element Activator (Ac). The Ac element is 4563 bp long and has an imperfect terminal repetition of 11 bp. The element contains two open reading frames (ORF) encoding polypeptides of 839 and 210 amino acids. Evidence derived from structura...

journal_title：Cell

authors： Pohlman RF,Fedoroff NV,Messing J

更新日期：1984-06-01 00:00:00

abstract：:The redox-regulated chaperone Hsp33 protects organisms against oxidative stress that leads to protein unfolding. Activation of Hsp33 is triggered by the oxidative unfolding of its own redox-sensor domain, making Hsp33 a member of a recently discovered class of chaperones that require partial unfolding for full chapero...

journal_title：Cell

authors： Reichmann D,Xu Y,Cremers CM,Ilbert M,Mittelman R,Fitzgerald MC,Jakob U

更新日期：2012-03-02 00:00:00

abstract：:As visualized by electron microscopy, RecA protein binds in a highly cooperative manner to single-stranded fd DNA in solutions of 0.01 M Tris (pH 7.5). The resulting nucleoprotein filament loops are 1.25 micrometers in length, have a fiber diameter of 12 nm and show an indication of a 4.5 nm repeat along the axis of t...

journal_title：Cell

authors： Dunn K,Chrysogelos S,Griffith J

更新日期：1982-04-01 00:00:00

abstract：:We describe the isolation and characterization of two unusual amber suppressor forms of T4 tRNALeu. The sequences of the suppressor tRNAs can be described as hybrids of wild-type tRNALeu and suppressor tRNAGln molecules: the chain lengths and majority of the nucleotide residues corresponded to tRNALeu, but CUA anticod...

journal_title：Cell

authors： McClain WH,Foss K

更新日期：1984-08-01 00:00:00

abstract：:NF-kappaB, a key regulator of the cellular inflammatory and immune response, is activated by the HTLV-I transforming and transactivating protein Tax. We show that Tax binds to the amino terminus of the protein kinase MEKK1, a component of an IkappaB kinase complex, and stimulates MEKK1 kinase activity. Tax expression ...

journal_title：Cell

authors： Yin MJ,Christerson LB,Yamamoto Y,Kwak YT,Xu S,Mercurio F,Barbosa M,Cobb MH,Gaynor RB

更新日期：1998-05-29 00:00:00

abstract：:We have isolated five clones containing human histone genes from a human genomic DNA library, using a cloned X. laevis histone H4 cDNA probe (pX1ch4). Each genomic clone has been mapped and the locations of the histone genes have been determined by blot hybridization and hybridization-selection of human histone mRNA. ...

journal_title：Cell

authors： Heintz N,Zernik M,Roeder RG

更新日期：1981-06-01 00:00:00

abstract：:Using immobilized PDGF receptor as an affinity reagent, we purified an 85 kd protein (p85) from cell lysates and we cloned its cDNA. The protein contains an SH3 domain and two SH2 domains that are homologous to domains found in several receptor-associated enzymes. Recombinant p85 overexpressed in mammalian cells inhib...

journal_title：Cell

authors： Escobedo JA,Navankasattusas S,Kavanaugh WM,Milfay D,Fried VA,Williams LT

更新日期：1991-04-05 00:00:00

abstract：:A long-standing question in the study of long-term memory is how a memory trace persists for years when the proteins that initiated the process turn over and disappear within days. Previously, we postulated that self-sustaining amyloidogenic oligomers of cytoplasmic polyadenylation element-binding protein (CPEB) provi...

journal_title：Cell

authors： Majumdar A,Cesario WC,White-Grindley E,Jiang H,Ren F,Khan MR,Li L,Choi EM,Kannan K,Guo F,Unruh J,Slaughter B,Si K

更新日期：2012-02-03 00:00:00

abstract：:How metazoan mechanotransduction channels sense mechanical stimuli is not well understood. The NOMPC channel in the transient receptor potential (TRP) family, a mechanotransduction channel for Drosophila touch sensation and hearing, contains 29 Ankyrin repeats (ARs) that associate with microtubules. These ARs have bee...

journal_title：Cell

authors： Zhang W,Cheng LE,Kittelmann M,Li J,Petkovic M,Cheng T,Jin P,Guo Z,Göpfert MC,Jan LY,Jan YN

更新日期：2015-09-10 00:00:00

abstract：:Characteristic of chronic myelogenous leukemia (CML) is the presence of the chimeric p210(bcr-abl) protein possessing elevated protein tyrosine kinase activity relative to normal c-abl tyrosine kinase. Hematopoietic progenitors isolated from CML patients in the chronic phase contain a constitutively tyrosine-phosphory...

journal_title：Cell

authors： Carpino N,Wisniewski D,Strife A,Marshak D,Kobayashi R,Stillman B,Clarkson B

更新日期：1997-01-24 00:00:00

abstract：:Endogenous and infectious mouse mammary tumor viruses (MMTVs) encode in their 3' long terminal repeat a protein that exerts superantigen activity; that is, it is able to interact with T cells via the variable domain of the T cell receptor (TCR) beta chain. We show here that transmission of an infectious MMTV is preven...

journal_title：Cell

authors： Held W,Waanders GA,Shakhov AN,Scarpellino L,Acha-Orbea H,MacDonald HR

更新日期：1993-08-13 00:00:00

abstract：:Chimeric histocompatibility genes encoding the amino-terminal (beta 1) domain of the class II Ak beta polypeptide and the carboxy-terminal (C2, transmembrane, and intracytoplasmic) domains of either the class I H-2Ld or H-2Dd molecules were stably introduced into mouse L cells. Although both were transcribed, only 5' ...

journal_title：Cell

authors： McCluskey J,Germain RN,Margulies DH

更新日期：1985-02-01 00:00:00

abstract：:Recombinant E. coli that produce light were found in a clone library of hybrid plasmids containing DNA from the marine bacterium Vibrio fischeri. All luminescent clones had a 16 kb insert that encoded enzymatic activities for the light reaction as well as regulatory functions necessary for expression of the luminescen...

journal_title：Cell

authors： Engebrecht J,Nealson K,Silverman M

更新日期：1983-03-01 00:00:00

abstract：:Fission yeast Cid13 and budding yeast Trf4/5 are members of a newly identified nucleotidyltransferase family conserved from yeast to man. Trf4/5 are thought to be essential DNA polymerases. We report that Cid13 is a poly(A) polymerase. Unlike conventional poly(A) polymerases, which act in the nucleus and indiscriminat...

journal_title：Cell

authors： Saitoh S,Chabes A,McDonald WH,Thelander L,Yates JR,Russell P

更新日期：2002-05-31 00:00:00

abstract：:The dual host range virus HIX has been previously characterized as an envelope gene recombinant between Moloney murine leukemia virus (Mo-MuLV) and an unidentified xenotropic murine leukemia virus. Using long reverse transcripts of Mo-MuLV, a region of nonhomology has been mapped by electron microscopic analysis of he...

journal_title：Cell

authors： Donoghue DJ,Rothenberg E,Hopkins N,Baltimore D,Sharp PA

更新日期：1978-08-01 00:00:00

abstract：:Suppressor of Hairless (Su(H)) is required at two stages of adult sensory organ development in Drosophila. Complete loss of Su(H) function results in a "neurogenic" phenotype in imaginal discs, in which too many cells adopt the sensory organ precursor cell fate. Su(H) is also involved in controlling the fates of sensi...

journal_title：Cell

authors： Schweisguth F,Posakony JW

更新日期：1992-06-26 00:00:00