HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation.

Abstract:

:NF-kappaB, a key regulator of the cellular inflammatory and immune response, is activated by the HTLV-I transforming and transactivating protein Tax. We show that Tax binds to the amino terminus of the protein kinase MEKK1, a component of an IkappaB kinase complex, and stimulates MEKK1 kinase activity. Tax expression increases the activity of IkappaB kinase beta (IKKbeta) to enhance phosphorylation of serine residues in IkappaB alpha that lead to its degradation. Dominant negative mutants of both IKKbeta and MEKK1 prevent Tax activation of the NF-kappaB pathway. Furthermore, recombinant MEKK1 stimulates IKKbeta phosphorylation of IkappaB alpha. Thus, Tax-mediated increases in NF-kappaB nuclear translocation result from direct interactions of Tax and MEKK1 leading to enhanced IKKbeta phosphorylation of IkappaB alpha.

journal_name

Cell

journal_title

Cell

authors

Yin MJ,Christerson LB,Yamamoto Y,Kwak YT,Xu S,Mercurio F,Barbosa M,Cobb MH,Gaynor RB

doi

10.1016/s0092-8674(00)81447-6

subject

Has Abstract

pub_date

1998-05-29 00:00:00

pages

875-84

issue

5

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(00)81447-6

journal_volume

93

pub_type

杂志文章

相关文献

CELL文献大全
  • The somatic replication of DNA methylation.

    abstract::We have tested the hypothesis that DNA methylation patterns are replicated in the somatic cells of vertebrates. Using M-Hpa II, the modification enzyme from Haemophilus parainfluenzae which methylates the internal cytosine residues in the sequence 5'CCGG 3' GGCC, we methylated bacteriophage phi X174 RF DNA and the clo...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(81)90498-0

    authors: Wigler M,Levy D,Perucho M

    更新日期:1981-04-01 00:00:00

  • Cell sorting during regenerative tissue formation.

    abstract::Regeneration of transected peripheral nerves is a complex process involving the coordinated action of neuronal axons, glial cells, and fibroblasts. Using rodent models of nerve repair, Parrinello et al. (2010) find that ephrin signaling between fibroblasts and Schwann cell progenitors, involving the stemness factor So...

    journal_title:Cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.cell.2010.09.018

    authors: Klein R

    更新日期:2010-10-01 00:00:00

  • Stabilizing HIF to Ameliorate Anemia.

    abstract::Erythropoietin (EPO) production in the kidney is regulated by the oxygen-sensing transcription factor HIF-1α, which is degraded under normoxic conditions by HIF-prolyl hydroxylase (HIF-PHD). Inhibition of HIF-PHD by roxadustat leads to increased EPO production, better iron absorption, and amelioration of anemia in chr...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2019.12.010

    authors: Voit RA,Sankaran VG

    更新日期:2020-01-09 00:00:00

  • RNA polymerase interactions with the upstream region of the E. coli tyrT promoter.

    abstract::The rate of in vivo transcription from the E. coli tRNA and rRNA promoters depends on both cellular growth rate and aminoacid availability. To investigate the molecular mechanisms involved we determined the extent of interaction of RNA polymerase with the promoter of the tyrT stable RNA gene. We show that the enzyme c...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(83)90229-5

    authors: Travers AA,Lamond AI,Mace HA,Berman ML

    更新日期:1983-11-01 00:00:00

  • MAC-1, a new genetically transmitted type C virus of primates: "low frequency" activation from stumptail monkey cell cultures.

    abstract::A new class of endogenous primate type C virus has been isolated from a continuous tissue culture line of Macaca arctoides cells by co-cultivation with a human cell line. The virus, designated MAC-1, can be transmitted to human and feline cells in tissue culture, and is unrelated, by immunological and nucleic acid hyb...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(78)90227-1

    authors: Todaro GJ,Benveniste RE,Sherwin SA,Sherr CJ

    更新日期:1978-04-01 00:00:00

  • The timing of developmental transitions in plants.

    abstract::Plants rely heavily on environmental cues to control the timing of developmental transitions. We are beginning to better understand what determines the timing of two of these transitions, the switch from juvenile to adult vegetative development and the transition to flowering. In this review, we discuss how RNA silenc...

    journal_title:Cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.cell.2006.05.005

    authors: Bäurle I,Dean C

    更新日期:2006-05-19 00:00:00

  • Transferrin receptors promote the formation of clathrin lattices.

    abstract::Gold conjugates have been used to quantitate human transferrin receptors (hTfnRs) on transfected chick embryo fibroblasts. No relationship could be found between the number of hTfnRs and the number of clathrin-coated pits. However, hTfnRs are also associated with flat clathrin lattices that lie outside invaginated pit...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(91)90094-f

    authors: Miller K,Shipman M,Trowbridge IS,Hopkins CR

    更新日期:1991-05-17 00:00:00

  • Site-specific base substitution and deletion mutations that enhance or suppress transcription of the SV40 major late RNA.

    abstract::Transcriptional analysis of SV40 late promoter mutants indicates that the DNA sequence 5'-GGTACCTAACC-3' (map positions 294-304) is important in the control of SV40 late RNA expression. C to T base substitutions at map positions 298, 299 and 304 increased initiation of late RNA synthesis at map position 325 five to te...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(82)90318-x

    authors: Brady J,Radonovich M,Vodkin M,Natarajan V,Thoren M,Das G,Janik J,Salzman NP

    更新日期:1982-12-01 00:00:00

  • TFIIH plays an essential role in RNA polymerase I transcription.

    abstract::TFIIH is a multisubunit protein complex that plays an essential role in nucleotide excision repair and transcription of protein-coding genes. Here, we report that TFIIH is also required for ribosomal RNA synthesis in vivo and in vitro. In yeast, pre-rRNA synthesis is impaired in TFIIH ts strains. In a mouse, part of c...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(02)00729-8

    authors: Iben S,Tschochner H,Bier M,Hoogstraten D,Hozák P,Egly JM,Grummt I

    更新日期:2002-05-03 00:00:00

  • Phase transition of spindle-associated protein regulate spindle apparatus assembly.

    abstract::Spindle assembly required during mitosis depends on microtubule polymerization. We demonstrate that the evolutionarily conserved low-complexity protein, BuGZ, undergoes phase transition or coacervation to promote assembly of both spindles and their associated components. BuGZ forms temperature-dependent liquid droplet...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2015.08.010

    authors: Jiang H,Wang S,Huang Y,He X,Cui H,Zhu X,Zheng Y

    更新日期:2015-09-24 00:00:00

  • Location of the cell-attachment site in fibronectin with monoclonal antibodies and proteolytic fragments of the molecule.

    abstract::Proteolytic fragments of human plasma fibronectin were used to identify monoclonal antibodies reacting with the various domains of fibronectin. One of these antibodies, which reacts with cell-attachment-promoting fragments of fibronectin, inhibits attachment of cells to fibronectin-coated surfaces. A cell-attachment-p...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(81)90308-1

    authors: Pierschbacher MD,Hayman EG,Ruoslahti E

    更新日期:1981-10-01 00:00:00

  • Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors.

    abstract::Nuclear receptors undergo ligand-dependent conformational changes that are required for corepressor-coactivator exchange, but whether there is an actual requirement for specific epigenetic landmarks to impose ligand dependency for gene activation remains unknown. Here we report an unexpected and general strategy that ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2006.12.038

    authors: Garcia-Bassets I,Kwon YS,Telese F,Prefontaine GG,Hutt KR,Cheng CS,Ju BG,Ohgi KA,Wang J,Escoubet-Lozach L,Rose DW,Glass CK,Fu XD,Rosenfeld MG

    更新日期:2007-02-09 00:00:00

  • Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development.

    abstract::We have isolated two adenylyl cyclase genes, designated ACA and ACG, from Dictyostelium. The proposed structure for ACA resembles that proposed for mammalian adenylyl cyclases: two large hydrophilic domains and two sets of six transmembrane spans. ACG has a novel structure, reminiscent of the membrane-bound guanylyl c...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(92)90411-5

    authors: Pitt GS,Milona N,Borleis J,Lin KC,Reed RR,Devreotes PN

    更新日期:1992-04-17 00:00:00

  • Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection.

    abstract::Hereditary xerocytosis is thought to be a rare genetic condition characterized by red blood cell (RBC) dehydration with mild hemolysis. RBC dehydration is linked to reduced Plasmodium infection in vitro; however, the role of RBC dehydration in protection against malaria in vivo is unknown. Most cases of hereditary xer...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2018.02.047

    authors: Ma S,Cahalan S,LaMonte G,Grubaugh ND,Zeng W,Murthy SE,Paytas E,Gamini R,Lukacs V,Whitwam T,Loud M,Lohia R,Berry L,Khan SM,Janse CJ,Bandell M,Schmedt C,Wengelnik K,Su AI,Honore E,Winzeler EA,Andersen KG,Patapou

    更新日期:2018-04-05 00:00:00

  • Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation.

    abstract::Ubiquitin chains serve as a recognition motif for the proteasome, a multisubunit protease, which degrades its substrates into polypeptides while releasing ubiquitin for reuse. Yeast proteasomes contain two deubiquitinating enzymes, Ubp6 and Rpn11. Rpn11 promotes protein breakdown through its degradation-coupled activi...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2006.07.038

    authors: Hanna J,Hathaway NA,Tone Y,Crosas B,Elsasser S,Kirkpatrick DS,Leggett DS,Gygi SP,King RW,Finley D

    更新日期:2006-10-06 00:00:00

  • Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1.

    abstract::Heat shock and other proteotoxic stresses cause accumulation of nonnative proteins that trigger activation of heat shock protein (Hsp) genes. A chaperone/Hsp functioning as repressor of heat shock transcription factor (HSF) could make activation of hsp genes dependent on protein unfolding. In a novel in vitro system, ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(00)81588-3

    authors: Zou J,Guo Y,Guettouche T,Smith DF,Voellmy R

    更新日期:1998-08-21 00:00:00

  • Coupling of a replicative polymerase and helicase: a tau-DnaB interaction mediates rapid replication fork movement.

    abstract::The E. coli replication fork synthesizes DNA at the rate of nearly 1000 nt/s. We show here that an interaction between the tau subunit of the replicative polymerase (the DNA polymerase III holoenzyme) and the replication fork DNA helicase (DnaB) is required to mediate this high rate of replication fork movement. In th...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(00)81039-9

    authors: Kim S,Dallmann HG,McHenry CS,Marians KJ

    更新日期:1996-02-23 00:00:00

  • Cells respond to mechanical stress by rapid disassembly of caveolae.

    abstract::The functions of caveolae, the characteristic plasma membrane invaginations, remain debated. Their abundance in cells experiencing mechanical stress led us to investigate their role in membrane-mediated mechanical response. Acute mechanical stress induced by osmotic swelling or by uniaxial stretching results in a rapi...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2010.12.031

    authors: Sinha B,Köster D,Ruez R,Gonnord P,Bastiani M,Abankwa D,Stan RV,Butler-Browne G,Vedie B,Johannes L,Morone N,Parton RG,Raposo G,Sens P,Lamaze C,Nassoy P

    更新日期:2011-02-04 00:00:00

  • Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release.

    abstract::We have identified mutations in Drosophila endophilin to study its function in vivo. Endophilin is required presynaptically at the neuromuscular junction, and absence of Endophilin dramatically impairs endocytosis in vivo. Mutant larvae that lack Endophilin fail to take up FM1-43 dye in synaptic boutons, indicating an...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(02)00688-8

    authors: Verstreken P,Kjaerulff O,Lloyd TE,Atkinson R,Zhou Y,Meinertzhagen IA,Bellen HJ

    更新日期:2002-04-05 00:00:00

  • Single-stranded DNA transposition is coupled to host replication.

    abstract::DNA transposition has contributed significantly to evolution of eukaryotes and prokaryotes. Insertion sequences (ISs) are the simplest prokaryotic transposons and are divided into families on the basis of their organization and transposition mechanism. Here, we describe a link between transposition of IS608 and ISDra2...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2010.06.034

    authors: Ton-Hoang B,Pasternak C,Siguier P,Guynet C,Hickman AB,Dyda F,Sommer S,Chandler M

    更新日期:2010-08-06 00:00:00

  • HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase.

    abstract::The karyophilic properties of the viral matrix (MA) protein govern HIV nuclear import in nondividing cells such as macrophages. A critical regulator of this process is the C-terminal tyrosine phosphorylation of MA during virus maturation. Here, we reveal the mechanism of this phenomenon, by demonstrating that tyrosine...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(95)90097-7

    authors: Gallay P,Swingler S,Song J,Bushman F,Trono D

    更新日期:1995-11-17 00:00:00

  • CD83 expression influences CD4+ T cell development in the thymus.

    abstract::T lymphocyte selection and lineage commitment in the thymus requires multiple signals. Herein, CD4+ T cell generation required engagement of CD83, a surface molecule expressed by thymic epithelial and dendritic cells. CD83-deficient (CD83-/-) mice had a specific block in CD4+ single-positive thymocyte development with...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(02)00673-6

    authors: Fujimoto Y,Tu L,Miller AS,Bock C,Fujimoto M,Doyle C,Steeber DA,Tedder TF

    更新日期:2002-03-22 00:00:00

  • The structure of the human histone genes: clustered but not tandemly repeated.

    abstract::We have isolated five clones containing human histone genes from a human genomic DNA library, using a cloned X. laevis histone H4 cDNA probe (pX1ch4). Each genomic clone has been mapped and the locations of the histone genes have been determined by blot hybridization and hybridization-selection of human histone mRNA. ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(81)90092-1

    authors: Heintz N,Zernik M,Roeder RG

    更新日期:1981-06-01 00:00:00

  • A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis.

    abstract::Ca(2+) binding to synaptotagmin 1 triggers fast exocytosis of synaptic vesicles that have been primed for release by SNARE-complex assembly. Besides synaptotagmin 1, fast Ca(2+)-triggered exocytosis requires complexins. Synaptotagmin 1 and complexins both bind to assembled SNARE complexes, but it is unclear how their ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2006.08.030

    authors: Tang J,Maximov A,Shin OH,Dai H,Rizo J,Südhof TC

    更新日期:2006-09-22 00:00:00

  • Role of a new Rho family member in cell migration and axon guidance in C. elegans.

    abstract::Rho family GTPases are thought to regulate actin-dependent processes, but their functions in vivo are still poorly understood. We have investigated the function of a new, widely expressed Rho family member in C. elegans by analyzing mutations in the endogenous gene. Activated and null alleles all inhibit cell migratio...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(00)80353-0

    authors: Zipkin ID,Kindt RM,Kenyon CJ

    更新日期:1997-09-05 00:00:00

  • A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase.

    abstract::A Drosophila gene with similarity to the mammalian Ras GTPase activating protein has been isolated in screens for mutations that affect eye development. Inactivation of the locus, Gap1, mimics constitutive activation of the Sevenless receptor tyrosine kinase and eliminates the need for a functional Sevenless protein i...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(92)90073-l

    authors: Gaul U,Mardon G,Rubin GM

    更新日期:1992-03-20 00:00:00

  • Direct induction by estradiol on vitellogenin synthesis in organ cultures of male Xenopus laevis liver.

    abstract::Organ cultures of liver from untreated male Xenopus respond to 17 beta-estradiol in the culture medium by synthesizing and secreting the yolk protein precursor vitellogenin. Vitellogenin synthesis, as a primary response, is first detectable on the fourth day of culture, and comprises up to 12% of the protein synthesiz...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(76)90263-4

    authors: Green CD,Tata JR

    更新日期:1976-01-01 00:00:00

  • A cellular gene encodes scrapie PrP 27-30 protein.

    abstract::A clone encoding PrP 27-30, the major protein in purified preparations of scrapie agent, was selected from a scrapie-infected hamster brain cDNA library by oligonucleotide probes corresponding to the N terminus of the protein. Southern blotting with PrP cDNA revealed a single gene with the same restriction patterns in...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(85)90333-2

    authors: Oesch B,Westaway D,Wälchli M,McKinley MP,Kent SB,Aebersold R,Barry RA,Tempst P,Teplow DB,Hood LE

    更新日期:1985-04-01 00:00:00

  • Cellular uptake of the tat protein from human immunodeficiency virus.

    abstract::While developing an assay to measure the activity of the tat protein from human immunodeficiency virus 1 (HIV-1), we discovered that the purified protein could be taken up by cells growing in tissue culture and subsequently trans-activate the viral promoter. Trans-activation is dramatically increased by a variety of l...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(88)90263-2

    authors: Frankel AD,Pabo CO

    更新日期:1988-12-23 00:00:00

  • Francis Crick: A Singular Approach to Scientific Discovery.

    abstract::Francis' office window (at the Salk) commanded a panorama of the Pacific. "This grand natural scene was a physical correlate of Francis's intellectual world: wide-ranging, brilliantly lit, a little overawing, but also immensely inviting and above all an exciting place to be." (Mitchison, 2004). ...

    journal_title:Cell

    pub_type: 传,历史文章,杂志文章

    doi:10.1016/j.cell.2016.11.008

    authors: Lawrence PA

    更新日期:2016-12-01 00:00:00