Abstract：
:During development, neurons switch among growth states, such as initial axon outgrowth, axon pruning, and regrowth. By studying the stereotypic remodeling of the Drosophila mushroom body (MB), we found that the heme-binding nuclear receptor E75 is dispensable for initial axon outgrowth of MB γ neurons but is required for their developmental regrowth. Genetic experiments and pharmacological manipulations on ex-vivo-cultured brains indicate that neuronally generated nitric oxide (NO) promotes pruning but inhibits regrowth. We found that high NO levels inhibit the physical interaction between the E75 and UNF nuclear receptors, likely accounting for its repression of regrowth. Additionally, NO synthase (NOS) activity is downregulated at the onset of regrowth, at least partially, by short inhibitory NOS isoforms encoded within the NOS locus, indicating how NO production could be developmentally regulated. Taken together, these results suggest that NO signaling provides a switching mechanism between the degenerative and regenerative states of neuronal remodeling.
journal_name
Celljournal_title
Cellauthors
Rabinovich D,Yaniv SP,Alyagor I,Schuldiner Odoi
10.1016/j.cell.2015.11.047subject
Has Abstractpub_date
2016-01-14 00:00:00pages
170-182issue
1-2eissn
0092-8674issn
1097-4172pii
S0092-8674(15)01566-4journal_volume
164pub_type
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