Abstract:
:γ-Secretase proteases have been associated with pathology in Alzheimer disease (AD), but we are just beginning to understand their basic mechanisms and physiological roles. A negative drug trial with a broad spectrum γ-secretase inhibitor in AD patients has severely dampened enthusiasm for the potential of pursuing γ-secretase research therapeutically. This pessimism is unwarranted: analysis of available information presented here demonstrates significant confounds for interpreting the outcome of the trial and argues that the major lessons pertain to broad knowledge gaps that are imperative to fill.
journal_name
Celljournal_title
Cellauthors
De Strooper Bdoi
10.1016/j.cell.2014.10.016subject
Has Abstractpub_date
2014-11-06 00:00:00pages
721-6issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(14)01304-Xjournal_volume
159pub_type
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